Prevalence of serum celiac antibody in patients with IBD in Japan

BACKGROUND: Although the incidence of inflammatory bowel diseases (IBD) in Japan has increased, the prevalence of celiac disease is considered very low with the lowest genetic disposition. IBD is reported as the most common comorbidity because of the high positive rate of serological celiac markers....

Descripción completa

Detalles Bibliográficos
Autores principales: Watanabe, Chikako, Komoto, Shunsuke, Hokari, Ryota, Kurihara, Chie, Okada, Yoshikiyo, Hozumi, Hideaki, Higashiyama, Masaaki, Sakuraba, Atsushi, Tomita, Kengo, Tsuzuki, Yoshikazu, Kawaguchi, Atsushi, Nagao, Shigeaki, Ogata, Sho, Miura, Soichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019828/
https://www.ncbi.nlm.nih.gov/pubmed/23754511
http://dx.doi.org/10.1007/s00535-013-0838-6
_version_ 1782480217742245888
author Watanabe, Chikako
Komoto, Shunsuke
Hokari, Ryota
Kurihara, Chie
Okada, Yoshikiyo
Hozumi, Hideaki
Higashiyama, Masaaki
Sakuraba, Atsushi
Tomita, Kengo
Tsuzuki, Yoshikazu
Kawaguchi, Atsushi
Nagao, Shigeaki
Ogata, Sho
Miura, Soichiro
author_facet Watanabe, Chikako
Komoto, Shunsuke
Hokari, Ryota
Kurihara, Chie
Okada, Yoshikiyo
Hozumi, Hideaki
Higashiyama, Masaaki
Sakuraba, Atsushi
Tomita, Kengo
Tsuzuki, Yoshikazu
Kawaguchi, Atsushi
Nagao, Shigeaki
Ogata, Sho
Miura, Soichiro
author_sort Watanabe, Chikako
collection PubMed
description BACKGROUND: Although the incidence of inflammatory bowel diseases (IBD) in Japan has increased, the prevalence of celiac disease is considered very low with the lowest genetic disposition. IBD is reported as the most common comorbidity because of the high positive rate of serological celiac markers. The aim of this study was to examine the current incidence of celiac disease, especially in IBD patients in Japan, where both wheat consumption and incidence of IBD have increased. METHODS: A total of 172 patients with IBD and 190 controls in Japan were screened for serum antibody of tissue transglutaminase and deaminated gliadin peptide. In sero-positive patients, HLA testing and upper gastrointestinal endoscopy with duodenal biopsy was performed. Some of the sero-positive patients started a gluten-restricted or unrestricted diet, and serological change was determined. RESULTS: The positivity of both serum antibodies was significantly higher in IBD and correlated with disease activity. However, no biopsy-defined or HLA-defined true celiac disease was found. A decrease in serum antibody titers was observed with a gluten-restricted diet. CONCLUSIONS: Despite the increased incidence of IBD and high positivity for serum celiac antibody in Japanese IBD patients, no true-positive celiac disease was noted, suggesting the presence of gluten intolerance in these populations.
format Online
Article
Text
id pubmed-4019828
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Springer Japan
record_format MEDLINE/PubMed
spelling pubmed-40198282014-05-14 Prevalence of serum celiac antibody in patients with IBD in Japan Watanabe, Chikako Komoto, Shunsuke Hokari, Ryota Kurihara, Chie Okada, Yoshikiyo Hozumi, Hideaki Higashiyama, Masaaki Sakuraba, Atsushi Tomita, Kengo Tsuzuki, Yoshikazu Kawaguchi, Atsushi Nagao, Shigeaki Ogata, Sho Miura, Soichiro J Gastroenterol Original Article—Alimentary Tract BACKGROUND: Although the incidence of inflammatory bowel diseases (IBD) in Japan has increased, the prevalence of celiac disease is considered very low with the lowest genetic disposition. IBD is reported as the most common comorbidity because of the high positive rate of serological celiac markers. The aim of this study was to examine the current incidence of celiac disease, especially in IBD patients in Japan, where both wheat consumption and incidence of IBD have increased. METHODS: A total of 172 patients with IBD and 190 controls in Japan were screened for serum antibody of tissue transglutaminase and deaminated gliadin peptide. In sero-positive patients, HLA testing and upper gastrointestinal endoscopy with duodenal biopsy was performed. Some of the sero-positive patients started a gluten-restricted or unrestricted diet, and serological change was determined. RESULTS: The positivity of both serum antibodies was significantly higher in IBD and correlated with disease activity. However, no biopsy-defined or HLA-defined true celiac disease was found. A decrease in serum antibody titers was observed with a gluten-restricted diet. CONCLUSIONS: Despite the increased incidence of IBD and high positivity for serum celiac antibody in Japanese IBD patients, no true-positive celiac disease was noted, suggesting the presence of gluten intolerance in these populations. Springer Japan 2013-06-12 2014 /pmc/articles/PMC4019828/ /pubmed/23754511 http://dx.doi.org/10.1007/s00535-013-0838-6 Text en © Springer Japan 2013
spellingShingle Original Article—Alimentary Tract
Watanabe, Chikako
Komoto, Shunsuke
Hokari, Ryota
Kurihara, Chie
Okada, Yoshikiyo
Hozumi, Hideaki
Higashiyama, Masaaki
Sakuraba, Atsushi
Tomita, Kengo
Tsuzuki, Yoshikazu
Kawaguchi, Atsushi
Nagao, Shigeaki
Ogata, Sho
Miura, Soichiro
Prevalence of serum celiac antibody in patients with IBD in Japan
title Prevalence of serum celiac antibody in patients with IBD in Japan
title_full Prevalence of serum celiac antibody in patients with IBD in Japan
title_fullStr Prevalence of serum celiac antibody in patients with IBD in Japan
title_full_unstemmed Prevalence of serum celiac antibody in patients with IBD in Japan
title_short Prevalence of serum celiac antibody in patients with IBD in Japan
title_sort prevalence of serum celiac antibody in patients with ibd in japan
topic Original Article—Alimentary Tract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019828/
https://www.ncbi.nlm.nih.gov/pubmed/23754511
http://dx.doi.org/10.1007/s00535-013-0838-6
work_keys_str_mv AT watanabechikako prevalenceofserumceliacantibodyinpatientswithibdinjapan
AT komotoshunsuke prevalenceofserumceliacantibodyinpatientswithibdinjapan
AT hokariryota prevalenceofserumceliacantibodyinpatientswithibdinjapan
AT kuriharachie prevalenceofserumceliacantibodyinpatientswithibdinjapan
AT okadayoshikiyo prevalenceofserumceliacantibodyinpatientswithibdinjapan
AT hozumihideaki prevalenceofserumceliacantibodyinpatientswithibdinjapan
AT higashiyamamasaaki prevalenceofserumceliacantibodyinpatientswithibdinjapan
AT sakurabaatsushi prevalenceofserumceliacantibodyinpatientswithibdinjapan
AT tomitakengo prevalenceofserumceliacantibodyinpatientswithibdinjapan
AT tsuzukiyoshikazu prevalenceofserumceliacantibodyinpatientswithibdinjapan
AT kawaguchiatsushi prevalenceofserumceliacantibodyinpatientswithibdinjapan
AT nagaoshigeaki prevalenceofserumceliacantibodyinpatientswithibdinjapan
AT ogatasho prevalenceofserumceliacantibodyinpatientswithibdinjapan
AT miurasoichiro prevalenceofserumceliacantibodyinpatientswithibdinjapan