HSV-1 and Alzheimer’s disease: more than a hypothesis

Among the multiple factors concurring to Alzheimer’s disease (AD) pathogenesis, greater attention should be devoted to the role played by infectious agents. Growing epidemiological and experimental evidence suggests that recurrent herpes simplex virus type-1 (HSV-1) infection is a risk factor for AD...

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Autores principales: Piacentini, Roberto, De Chiara, Giovanna, Li Puma, Domenica D., Ripoli, Cristian, Marcocci, Maria E., Garaci, Enrico, Palamara, Anna T., Grassi, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019841/
https://www.ncbi.nlm.nih.gov/pubmed/24847267
http://dx.doi.org/10.3389/fphar.2014.00097
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author Piacentini, Roberto
De Chiara, Giovanna
Li Puma, Domenica D.
Ripoli, Cristian
Marcocci, Maria E.
Garaci, Enrico
Palamara, Anna T.
Grassi, Claudio
author_facet Piacentini, Roberto
De Chiara, Giovanna
Li Puma, Domenica D.
Ripoli, Cristian
Marcocci, Maria E.
Garaci, Enrico
Palamara, Anna T.
Grassi, Claudio
author_sort Piacentini, Roberto
collection PubMed
description Among the multiple factors concurring to Alzheimer’s disease (AD) pathogenesis, greater attention should be devoted to the role played by infectious agents. Growing epidemiological and experimental evidence suggests that recurrent herpes simplex virus type-1 (HSV-1) infection is a risk factor for AD although the underlying molecular and functional mechanisms have not been fully elucidated yet. Here, we review literature suggesting the involvement of HSV-1 infection in AD also briefly mentioning possible pharmacological implications of these findings.
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spelling pubmed-40198412014-05-20 HSV-1 and Alzheimer’s disease: more than a hypothesis Piacentini, Roberto De Chiara, Giovanna Li Puma, Domenica D. Ripoli, Cristian Marcocci, Maria E. Garaci, Enrico Palamara, Anna T. Grassi, Claudio Front Pharmacol Pharmacology Among the multiple factors concurring to Alzheimer’s disease (AD) pathogenesis, greater attention should be devoted to the role played by infectious agents. Growing epidemiological and experimental evidence suggests that recurrent herpes simplex virus type-1 (HSV-1) infection is a risk factor for AD although the underlying molecular and functional mechanisms have not been fully elucidated yet. Here, we review literature suggesting the involvement of HSV-1 infection in AD also briefly mentioning possible pharmacological implications of these findings. Frontiers Media S.A. 2014-05-07 /pmc/articles/PMC4019841/ /pubmed/24847267 http://dx.doi.org/10.3389/fphar.2014.00097 Text en Copyright © 2014 Piacentini, De Chiara, Li Puma, Ripoli, Marcocci, Garaci, Palamara and Grassi. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Piacentini, Roberto
De Chiara, Giovanna
Li Puma, Domenica D.
Ripoli, Cristian
Marcocci, Maria E.
Garaci, Enrico
Palamara, Anna T.
Grassi, Claudio
HSV-1 and Alzheimer’s disease: more than a hypothesis
title HSV-1 and Alzheimer’s disease: more than a hypothesis
title_full HSV-1 and Alzheimer’s disease: more than a hypothesis
title_fullStr HSV-1 and Alzheimer’s disease: more than a hypothesis
title_full_unstemmed HSV-1 and Alzheimer’s disease: more than a hypothesis
title_short HSV-1 and Alzheimer’s disease: more than a hypothesis
title_sort hsv-1 and alzheimer’s disease: more than a hypothesis
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019841/
https://www.ncbi.nlm.nih.gov/pubmed/24847267
http://dx.doi.org/10.3389/fphar.2014.00097
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