Cargando…

A randomized pilot phase I study of modified carcinoembryonic antigen (CEA) peptide (CAP1-6D)/montanide/GM-CSF-vaccine in patients with pancreatic adenocarcinoma

BACKGROUND: CEA is expressed in >90% of pancreatic cancers (PC) and may be an appropriate immunotherapy target. CEA is poorly immunogenic due to immune tolerance; CAP1-6D, an altered peptide ligand can help bypass tolerance. We conducted a pilot randomized phase I trial in PC patients to determin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Geynisman, Daniel M, Zha, Yuanyuan, Kunnavakkam, Rangesh, Aklilu, Mebea, Catenacci, Daniel VT, Polite, Blase N, Rosenbaum, Cara, Namakydoust, Azadeh, Karrison, Theodore, Gajewski, Thomas F, Kindler, Hedy L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019890/ https://www.ncbi.nlm.nih.gov/pubmed/24829746 http://dx.doi.org/10.1186/2051-1426-1-8

Ejemplares similares

Carcinoembryonic antigen (CEA) "fingerprints".
por: Rule, A. H., et al.
Publicado: (1973)

First British standard for carcinoembryonic antigen (CEA).
por: Laurence, D. J., et al.
Publicado: (1975)

Immunochemical studies of carcinoembryonic antigen (CEA) variants.
por: Ichiki, A. T., et al.
Publicado: (1976)

Tumor genome analysis includes germline genome: Are we ready for surprises?
por: Catenacci, Daniel VT, et al.
Publicado: (2015)

Epitopes of carcinoembryonic antigen (CEA) defined by monoclonal antibodies.
por: Price, M. R.
Publicado: (1988)

A monkey antigen crossreacting with carcinoembryonic antigen, CEA.
por: Engvall, E., et al.
Publicado: (1976)

Phase II Prospective, Open-Label Randomized Controlled Trial Comparing Standard of Care Chemotherapy With and Without Sequential Cytoreductive Interventions for Patients with Oligometastatic Foregut Adenocarcinoma and Undetectable Circulating Tumor Deoxyribose Nucleic Acid (ctDNA) Levels
por: Dhiman, Ankit, et al.
Publicado: (2022)

Immunological Study of Carcinoembryonic Antigen (CEA) and a Related Glycoprotein
por: Darcy, D. A., et al.
Publicado: (1973)

Immunological comparison of carcinoembryonic antigen (CEA) extracted from tumours of various organs: their use in radioimmunological CEA determinations.
por: Lamerz, R., et al.
Publicado: (1983)

Carcinoembryonic antigen (CEA) plasma levels in Michigan and Wisconsin dairy farmers.
por: Anderson, H A, et al.
Publicado: (1978)

A Comprehensive Phylogenetic and Structural Analysis of the Carcinoembryonic Antigen (CEA) Gene Family
por: Pavlopoulou, Athanasia, et al.
Publicado: (2014)

Carcinoembryonic antigen (CEA) level, CEA ratio, and treatment outcome of rectal cancer patients receiving pre-operative chemoradiation and surgery
por: Yang, Kai-Lin, et al.
Publicado: (2013)

Carcinoembryonic Antigen (CEA)-Specific 4-1BB-Costimulation Induced by CEA-Targeted 4-1BB-Agonistic Trimerbodies
por: Mikkelsen, Kasper, et al.
Publicado: (2019)

Postoperative carcinoembryonic antigen (CEA) levels predict outcomes after resection of colorectal cancer in patients with normal preoperative CEA levels
por: Zhang, Chiming, et al.
Publicado: (2020)

Late toxicity and quality of life after definitive treatment of prostate cancer: redefining optimal rectal sparing constraints for intensity-modulated radiation therapy
por: Chennupati, Sravana K, et al.
Publicado: (2014)

Phylogenetic discordance of human and canine carcinoembryonic antigen (CEA, CEACAM) families, but striking identity of the CEA receptors will impact comparative oncology studies.
por: Weichselbaumer, Marlene, et al.
Publicado: (2011)

Hookah smoking and cancer: carcinoembryonic antigen (CEA) levels in exclusive/ever hookah smokers
por: Sajid, Khan Mohammad, et al.
Publicado: (2008)

Urinary carcinoembryonic antigen (CEA)-like molecules and urothelial malignancy: a clinical appraisal.
por: Coombers, G. B., et al.
Publicado: (1975)

Safety data of Montanide ISA 51 VG and Montanide ISA 720 VG, two adjuvants dedicated to human therapeutic vaccines
por: Ascarateil, Stephane, et al.
Publicado: (2015)

Next‐generation clinical trials: Novel strategies to address the challenge of tumor molecular heterogeneity
por: Catenacci, Daniel V.T.
Publicado: (2014)

Sustained release of actives with Montanide™ ISA 51 VG and Montanide™ ISA 720 VG, two adjuvants dedicated to human therapeutic vaccines
por: Ascarateil, Stephane, et al.
Publicado: (2015)

Paraneoplastic Leukocytosis and Thrombocytosis as Prognostic Biomarkers in Non-small Cell Lung Cancer
por: BODDU, Prajwal, et al.
Publicado: (2016)

Proceedings: Measurement of carcinoembryonic antigen (CEA) in normal subjects and in various neoplastic and non-neoplastic disorders.
por: Franchimont, P., et al.
Publicado: (1974)

Comparison of CA 19-9 and carcinoembryonic antigen (CEA) levels in the serum of patients with colorectal diseases.
por: Kuusela, P., et al.
Publicado: (1984)

Localisation of monoclonal antibodies reacting with different epitopes on carcinoembryonic antigen (CEA)--implications for targeted therapy.
por: Boxer, G. M., et al.
Publicado: (1994)

Biological therapy: approaches in colorectal cancer. Strategies to enhance carcinoembryonic antigen (CEA) as an immunogenic target.
por: Zbar, A. P., et al.
Publicado: (1998)

Elevated Level of Serum Carcinoembryonic Antigen (CEA) and Search for a Malignancy: A Case Report
por: Asad-Ur-Rahman, FNU, et al.
Publicado: (2016)

Comparative Study of Blood, Tissue and Serum Levels of Carcinoembryonic Antigen (CEA) Detection in Breast Cancer
por: Moazzezy, Neda, et al.
Publicado: (2019)

Northern Latitude but Not Season Is Associated with Increased Rates of Hospitalizations Related to Inflammatory Bowel Disease: Results of a Multi-Year Analysis of a National Cohort
por: Stein, Adam C., et al.
Publicado: (2016)

Expression of carcinoembryonic antigen (CEA) and nonspecific crossreacting antigen (NCA) in gastrointestinal cancer; the correlation with degree of differentiation.
por: Kodera, Y., et al.
Publicado: (1993)

Factors influencing variability of localisation of antibodies to carcinoembryonic antigen (CEA) in patients with colorectal carcinoma--implications for radioimmunotherapy.
por: Boxer, G. M., et al.
Publicado: (1992)

Colorectal Hyperplasia and Dysplasia Due to Human Carcinoembryonic Antigen (CEA) Family Member Expression in Transgenic Mice
por: Chan, Carlos H. F., et al.
Publicado: (2007)

Immune System Modulation by the Adjuvants Poly (I:C) and Montanide ISA 720
por: Marques, Rodolfo F., et al.
Publicado: (2022)

Perioperative therapy for locally advanced gastroesophageal cancer: current controversies and consensus of care
por: Sehdev, Amikar, et al.
Publicado: (2013)

Carcinoembryonic antigen (CEA) expression and heterogeneity in primary and autologous metastatic gastric tumours demonstrated by a monoclonal antibody.
por: Hockey, M. S., et al.
Publicado: (1984)

Baseline carcinoembryonic antigen (CEA) serum levels predict bevacizumab-based treatment response in metastatic colorectal cancer
por: Prager, Gerald W, et al.
Publicado: (2014)

Imaging of Recurrent Intestinal Carcinoma with Indium‐lll‐labeled Anti‐carcinoembryonic Antigen Monoclonal Antibody CEA102
por: Nakada, Kazuhiko, et al.
Publicado: (1997)

Carcinoembryonic antigen (CEA) in explants of human breast cancer: comparison of immunohistochemical detection and release during short-term culture.
por: Miller, W. R., et al.
Publicado: (1983)

Advantages of the AMDL-ELISA DR-70 (FDP) Assay over Carcinoembryonic Antigen (CEA) for Monitoring Colorectal Cancer Patients
por: Small-Howard, Andrea L., et al.
Publicado: (2010)

The CEA Second-Look Trial: a randomised controlled trial of carcinoembryonic antigen prompted reoperation for recurrent colorectal cancer
por: Treasure, Tom, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ebi4eretvvsh4i608k0biacgov