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Acute Acalculous Cholecystitis in a Patient with Metastatic Renal Cell Carcinoma Treated with Sunitinib
A 55-year old man was treated with sunitinib 50 mg/day for 4 weeks on and 2 weeks off, as a first-line therapy for metastatic renal cell carcinoma. During the fourth week of the first cycle, he was admitted to the Emergency Department with abdominal pain and vomiting. Acute acalculous cholecystitis...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PAGEPress Publications, Pavia, Italy
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019924/ https://www.ncbi.nlm.nih.gov/pubmed/24847435 http://dx.doi.org/10.4081/cp.2014.635 |
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author | da Fonseca, Leonardo Gomes Barroso-Sousa, Romualdo Sabbaga, Jorge Hoff, Paulo Marcelo |
author_facet | da Fonseca, Leonardo Gomes Barroso-Sousa, Romualdo Sabbaga, Jorge Hoff, Paulo Marcelo |
author_sort | da Fonseca, Leonardo Gomes |
collection | PubMed |
description | A 55-year old man was treated with sunitinib 50 mg/day for 4 weeks on and 2 weeks off, as a first-line therapy for metastatic renal cell carcinoma. During the fourth week of the first cycle, he was admitted to the Emergency Department with abdominal pain and vomiting. Acute acalculous cholecystitis was diagnosed. Sunitnib-associated cholecystitis is a rare adverse event previously reported in few cases. The mechanism behind this complication is not fully understood, although vascular endothelial dysfunction may play a role. The use of this drug is expanding in clinical oncology, and physicians should be aware of this life-threating adverse event. |
format | Online Article Text |
id | pubmed-4019924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | PAGEPress Publications, Pavia, Italy |
record_format | MEDLINE/PubMed |
spelling | pubmed-40199242014-05-20 Acute Acalculous Cholecystitis in a Patient with Metastatic Renal Cell Carcinoma Treated with Sunitinib da Fonseca, Leonardo Gomes Barroso-Sousa, Romualdo Sabbaga, Jorge Hoff, Paulo Marcelo Clin Pract Case Report A 55-year old man was treated with sunitinib 50 mg/day for 4 weeks on and 2 weeks off, as a first-line therapy for metastatic renal cell carcinoma. During the fourth week of the first cycle, he was admitted to the Emergency Department with abdominal pain and vomiting. Acute acalculous cholecystitis was diagnosed. Sunitnib-associated cholecystitis is a rare adverse event previously reported in few cases. The mechanism behind this complication is not fully understood, although vascular endothelial dysfunction may play a role. The use of this drug is expanding in clinical oncology, and physicians should be aware of this life-threating adverse event. PAGEPress Publications, Pavia, Italy 2014-04-30 /pmc/articles/PMC4019924/ /pubmed/24847435 http://dx.doi.org/10.4081/cp.2014.635 Text en ©Copyright L. Gomes da Fonseca et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution NonCommercial 3.0 License (CC BYNC 3.0) |
spellingShingle | Case Report da Fonseca, Leonardo Gomes Barroso-Sousa, Romualdo Sabbaga, Jorge Hoff, Paulo Marcelo Acute Acalculous Cholecystitis in a Patient with Metastatic Renal Cell Carcinoma Treated with Sunitinib |
title | Acute Acalculous Cholecystitis in a Patient with Metastatic Renal Cell Carcinoma Treated with Sunitinib |
title_full | Acute Acalculous Cholecystitis in a Patient with Metastatic Renal Cell Carcinoma Treated with Sunitinib |
title_fullStr | Acute Acalculous Cholecystitis in a Patient with Metastatic Renal Cell Carcinoma Treated with Sunitinib |
title_full_unstemmed | Acute Acalculous Cholecystitis in a Patient with Metastatic Renal Cell Carcinoma Treated with Sunitinib |
title_short | Acute Acalculous Cholecystitis in a Patient with Metastatic Renal Cell Carcinoma Treated with Sunitinib |
title_sort | acute acalculous cholecystitis in a patient with metastatic renal cell carcinoma treated with sunitinib |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019924/ https://www.ncbi.nlm.nih.gov/pubmed/24847435 http://dx.doi.org/10.4081/cp.2014.635 |
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