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Acute Acalculous Cholecystitis in a Patient with Metastatic Renal Cell Carcinoma Treated with Sunitinib

A 55-year old man was treated with sunitinib 50 mg/day for 4 weeks on and 2 weeks off, as a first-line therapy for metastatic renal cell carcinoma. During the fourth week of the first cycle, he was admitted to the Emergency Department with abdominal pain and vomiting. Acute acalculous cholecystitis...

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Autores principales: da Fonseca, Leonardo Gomes, Barroso-Sousa, Romualdo, Sabbaga, Jorge, Hoff, Paulo Marcelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019924/
https://www.ncbi.nlm.nih.gov/pubmed/24847435
http://dx.doi.org/10.4081/cp.2014.635
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author da Fonseca, Leonardo Gomes
Barroso-Sousa, Romualdo
Sabbaga, Jorge
Hoff, Paulo Marcelo
author_facet da Fonseca, Leonardo Gomes
Barroso-Sousa, Romualdo
Sabbaga, Jorge
Hoff, Paulo Marcelo
author_sort da Fonseca, Leonardo Gomes
collection PubMed
description A 55-year old man was treated with sunitinib 50 mg/day for 4 weeks on and 2 weeks off, as a first-line therapy for metastatic renal cell carcinoma. During the fourth week of the first cycle, he was admitted to the Emergency Department with abdominal pain and vomiting. Acute acalculous cholecystitis was diagnosed. Sunitnib-associated cholecystitis is a rare adverse event previously reported in few cases. The mechanism behind this complication is not fully understood, although vascular endothelial dysfunction may play a role. The use of this drug is expanding in clinical oncology, and physicians should be aware of this life-threating adverse event.
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spelling pubmed-40199242014-05-20 Acute Acalculous Cholecystitis in a Patient with Metastatic Renal Cell Carcinoma Treated with Sunitinib da Fonseca, Leonardo Gomes Barroso-Sousa, Romualdo Sabbaga, Jorge Hoff, Paulo Marcelo Clin Pract Case Report A 55-year old man was treated with sunitinib 50 mg/day for 4 weeks on and 2 weeks off, as a first-line therapy for metastatic renal cell carcinoma. During the fourth week of the first cycle, he was admitted to the Emergency Department with abdominal pain and vomiting. Acute acalculous cholecystitis was diagnosed. Sunitnib-associated cholecystitis is a rare adverse event previously reported in few cases. The mechanism behind this complication is not fully understood, although vascular endothelial dysfunction may play a role. The use of this drug is expanding in clinical oncology, and physicians should be aware of this life-threating adverse event. PAGEPress Publications, Pavia, Italy 2014-04-30 /pmc/articles/PMC4019924/ /pubmed/24847435 http://dx.doi.org/10.4081/cp.2014.635 Text en ©Copyright L. Gomes da Fonseca et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution NonCommercial 3.0 License (CC BYNC 3.0)
spellingShingle Case Report
da Fonseca, Leonardo Gomes
Barroso-Sousa, Romualdo
Sabbaga, Jorge
Hoff, Paulo Marcelo
Acute Acalculous Cholecystitis in a Patient with Metastatic Renal Cell Carcinoma Treated with Sunitinib
title Acute Acalculous Cholecystitis in a Patient with Metastatic Renal Cell Carcinoma Treated with Sunitinib
title_full Acute Acalculous Cholecystitis in a Patient with Metastatic Renal Cell Carcinoma Treated with Sunitinib
title_fullStr Acute Acalculous Cholecystitis in a Patient with Metastatic Renal Cell Carcinoma Treated with Sunitinib
title_full_unstemmed Acute Acalculous Cholecystitis in a Patient with Metastatic Renal Cell Carcinoma Treated with Sunitinib
title_short Acute Acalculous Cholecystitis in a Patient with Metastatic Renal Cell Carcinoma Treated with Sunitinib
title_sort acute acalculous cholecystitis in a patient with metastatic renal cell carcinoma treated with sunitinib
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019924/
https://www.ncbi.nlm.nih.gov/pubmed/24847435
http://dx.doi.org/10.4081/cp.2014.635
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