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Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction

Mutations in the gene that encodes the atypical channel-kinase TRPM6 (transient receptor potential melastatin 6) cause HSH (hypomagnesaemia with secondary hypocalcaemia), a disorder characterized by defective intestinal Mg(2+) transport and impaired renal Mg(2+) reabsorption. TRPM6, together with it...

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Detalles Bibliográficos
Autores principales:	vanderWijst, Jenny, Blanchard, Maxime G., Woodroof, Helen I., Macartney, Thomas J., Gourlay, Robert, Hoenderop, Joost G., Bindels, René J., Alessi, Dario R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019984/ https://www.ncbi.nlm.nih.gov/pubmed/24650431 http://dx.doi.org/10.1042/BJ20131639

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