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Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation

WNK1 [with no lysine (K)] and WNK4 regulate blood pressure by controlling the activity of ion co-transporters in the kidney. Groundbreaking work has revealed that the ubiquitylation and hence levels of WNK isoforms are controlled by a Cullin-RING E3 ubiquitin ligase complex (CRL3(KLHL3)) that utiliz...

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Detalles Bibliográficos
Autores principales:	Schumacher, Frances-Rose, Sorrell, Fiona J., Alessi, Dario R., Bullock, Alex N., Kurz, Thimo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019986/ https://www.ncbi.nlm.nih.gov/pubmed/24641320 http://dx.doi.org/10.1042/BJ20140153

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