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Subnormal Peripheral Blood Leukocyte Counts Are Related to the Lowest Prevalence and Incidence of Metabolic Syndrome: Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study

Few studies have assessed the relationship between a subnormal inflammatory status and metabolic syndrome (MS). We therefore designed a cross-sectional and 5-year cohort study to evaluate how a subnormal peripheral blood leukocyte count is related to MS. Participants were recruited from Tianjin Medi...

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Autores principales: Sun, Shaomei, Wu, Hongmei, Zhang, Qing, Wang, Chongjin, Guo, Yinting, Du, Huanmin, Liu, Li, Jia, Qiyu, Wang, Xing, Song, Kun, Niu, Kaijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020212/
https://www.ncbi.nlm.nih.gov/pubmed/24876672
http://dx.doi.org/10.1155/2014/412386
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author Sun, Shaomei
Wu, Hongmei
Zhang, Qing
Wang, Chongjin
Guo, Yinting
Du, Huanmin
Liu, Li
Jia, Qiyu
Wang, Xing
Song, Kun
Niu, Kaijun
author_facet Sun, Shaomei
Wu, Hongmei
Zhang, Qing
Wang, Chongjin
Guo, Yinting
Du, Huanmin
Liu, Li
Jia, Qiyu
Wang, Xing
Song, Kun
Niu, Kaijun
author_sort Sun, Shaomei
collection PubMed
description Few studies have assessed the relationship between a subnormal inflammatory status and metabolic syndrome (MS). We therefore designed a cross-sectional and 5-year cohort study to evaluate how a subnormal peripheral blood leukocyte count is related to MS. Participants were recruited from Tianjin Medical University General Hospital-Health Management Centre. Both a baseline cross-sectional (n = 46,179) and a prospective assessment (n = 13,061) were performed. Participants without a history of MS were followed up for 5 years. Leukocyte counts and MS components were assessed at baseline and yearly during the follow-up. Adjusted logistic and Cox proportional hazards regression models were used to assess relationships between the categories of leukocyte counts and MS. The subnormal leukocyte counts group (1,100–3,900 cells/mm(3)) had the lowest prevalence and incidence of MS. The odds ratio and hazard ratio (95% confidence interval) of the highest leukocyte counts were 1.98 (1.57–2.49) and 1.50 (1.22–1.84) (both P for trend <0.0001), respectively, when compared to the subnormal leukocyte counts group after adjusting for potential confounders. This study has shown that subnormal leukocyte counts are independently related to the lowest prevalence and incidence of MS. The findings suggest that it is necessary to restudy and discuss the clinical or preventive value of subnormal leukocyte counts.
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spelling pubmed-40202122014-05-29 Subnormal Peripheral Blood Leukocyte Counts Are Related to the Lowest Prevalence and Incidence of Metabolic Syndrome: Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study Sun, Shaomei Wu, Hongmei Zhang, Qing Wang, Chongjin Guo, Yinting Du, Huanmin Liu, Li Jia, Qiyu Wang, Xing Song, Kun Niu, Kaijun Mediators Inflamm Research Article Few studies have assessed the relationship between a subnormal inflammatory status and metabolic syndrome (MS). We therefore designed a cross-sectional and 5-year cohort study to evaluate how a subnormal peripheral blood leukocyte count is related to MS. Participants were recruited from Tianjin Medical University General Hospital-Health Management Centre. Both a baseline cross-sectional (n = 46,179) and a prospective assessment (n = 13,061) were performed. Participants without a history of MS were followed up for 5 years. Leukocyte counts and MS components were assessed at baseline and yearly during the follow-up. Adjusted logistic and Cox proportional hazards regression models were used to assess relationships between the categories of leukocyte counts and MS. The subnormal leukocyte counts group (1,100–3,900 cells/mm(3)) had the lowest prevalence and incidence of MS. The odds ratio and hazard ratio (95% confidence interval) of the highest leukocyte counts were 1.98 (1.57–2.49) and 1.50 (1.22–1.84) (both P for trend <0.0001), respectively, when compared to the subnormal leukocyte counts group after adjusting for potential confounders. This study has shown that subnormal leukocyte counts are independently related to the lowest prevalence and incidence of MS. The findings suggest that it is necessary to restudy and discuss the clinical or preventive value of subnormal leukocyte counts. Hindawi Publishing Corporation 2014 2014-04-29 /pmc/articles/PMC4020212/ /pubmed/24876672 http://dx.doi.org/10.1155/2014/412386 Text en Copyright © 2014 Shaomei Sun et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sun, Shaomei
Wu, Hongmei
Zhang, Qing
Wang, Chongjin
Guo, Yinting
Du, Huanmin
Liu, Li
Jia, Qiyu
Wang, Xing
Song, Kun
Niu, Kaijun
Subnormal Peripheral Blood Leukocyte Counts Are Related to the Lowest Prevalence and Incidence of Metabolic Syndrome: Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study
title Subnormal Peripheral Blood Leukocyte Counts Are Related to the Lowest Prevalence and Incidence of Metabolic Syndrome: Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study
title_full Subnormal Peripheral Blood Leukocyte Counts Are Related to the Lowest Prevalence and Incidence of Metabolic Syndrome: Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study
title_fullStr Subnormal Peripheral Blood Leukocyte Counts Are Related to the Lowest Prevalence and Incidence of Metabolic Syndrome: Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study
title_full_unstemmed Subnormal Peripheral Blood Leukocyte Counts Are Related to the Lowest Prevalence and Incidence of Metabolic Syndrome: Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study
title_short Subnormal Peripheral Blood Leukocyte Counts Are Related to the Lowest Prevalence and Incidence of Metabolic Syndrome: Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study
title_sort subnormal peripheral blood leukocyte counts are related to the lowest prevalence and incidence of metabolic syndrome: tianjin chronic low-grade systemic inflammation and health cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020212/
https://www.ncbi.nlm.nih.gov/pubmed/24876672
http://dx.doi.org/10.1155/2014/412386
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