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Leucocyte Telomere Shortening in relation to Newly Diagnosed Type 2 Diabetic Patients with Depression
The goal of this study is to investigate the association between oxidative stress and telomere length shortening in the comorbid depression and diabetes. Therefore, 71 patients with newly diagnosed type 2 diabetes (T2D) and 52 subjects with normal glycemic level (control, Ctrl) were enrolled. Depres...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020220/ https://www.ncbi.nlm.nih.gov/pubmed/24868316 http://dx.doi.org/10.1155/2014/673959 |
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author | Liu, Zhelong Zhang, Jianhua Yan, Jiangtao Wang, Yuping Li, Yongsheng |
author_facet | Liu, Zhelong Zhang, Jianhua Yan, Jiangtao Wang, Yuping Li, Yongsheng |
author_sort | Liu, Zhelong |
collection | PubMed |
description | The goal of this study is to investigate the association between oxidative stress and telomere length shortening in the comorbid depression and diabetes. Therefore, 71 patients with newly diagnosed type 2 diabetes (T2D) and 52 subjects with normal glycemic level (control, Ctrl) were enrolled. Depressive status was identified with the Depression Subscale of Hospital Anxiety and Depression Scale (HADS-D). Leukocyte telomere length ratio (T/S ratio) was determined with quantitative PCR. Oxidative stress status was evaluated with 8-hydroxy-desoxyguanosine (8-OHdG) assay kit. Some other biochemical blood testing was also performed. The data showed that T2D patients had higher proportion of depression evaluated by the HADS-D (x (2) = 4.196, P = 0.041). T/S ratio was significantly negatively correlated with 8-OHdG, HADS-D, age, HbA1c, FPG, and HOMA-IR. In addition, HADS-D was significantly positively correlated with HbA1c, FPG, HOMA-IR, and 8-OHdG. Both HADS-D and 8-OHdG were the major independent predictors for T/S ratio. This study indicates that oxidative stress contributes to both telomere length shortening and depression development in newly diagnosed type 2 diabetic patients, while in depression status, some other mechanisms besides oxidative stress may also affect the telomere length. |
format | Online Article Text |
id | pubmed-4020220 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40202202014-05-27 Leucocyte Telomere Shortening in relation to Newly Diagnosed Type 2 Diabetic Patients with Depression Liu, Zhelong Zhang, Jianhua Yan, Jiangtao Wang, Yuping Li, Yongsheng Oxid Med Cell Longev Research Article The goal of this study is to investigate the association between oxidative stress and telomere length shortening in the comorbid depression and diabetes. Therefore, 71 patients with newly diagnosed type 2 diabetes (T2D) and 52 subjects with normal glycemic level (control, Ctrl) were enrolled. Depressive status was identified with the Depression Subscale of Hospital Anxiety and Depression Scale (HADS-D). Leukocyte telomere length ratio (T/S ratio) was determined with quantitative PCR. Oxidative stress status was evaluated with 8-hydroxy-desoxyguanosine (8-OHdG) assay kit. Some other biochemical blood testing was also performed. The data showed that T2D patients had higher proportion of depression evaluated by the HADS-D (x (2) = 4.196, P = 0.041). T/S ratio was significantly negatively correlated with 8-OHdG, HADS-D, age, HbA1c, FPG, and HOMA-IR. In addition, HADS-D was significantly positively correlated with HbA1c, FPG, HOMA-IR, and 8-OHdG. Both HADS-D and 8-OHdG were the major independent predictors for T/S ratio. This study indicates that oxidative stress contributes to both telomere length shortening and depression development in newly diagnosed type 2 diabetic patients, while in depression status, some other mechanisms besides oxidative stress may also affect the telomere length. Hindawi Publishing Corporation 2014 2014-04-29 /pmc/articles/PMC4020220/ /pubmed/24868316 http://dx.doi.org/10.1155/2014/673959 Text en Copyright © 2014 Zhelong Liu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Liu, Zhelong Zhang, Jianhua Yan, Jiangtao Wang, Yuping Li, Yongsheng Leucocyte Telomere Shortening in relation to Newly Diagnosed Type 2 Diabetic Patients with Depression |
title | Leucocyte Telomere Shortening in relation to Newly Diagnosed Type 2 Diabetic Patients with Depression |
title_full | Leucocyte Telomere Shortening in relation to Newly Diagnosed Type 2 Diabetic Patients with Depression |
title_fullStr | Leucocyte Telomere Shortening in relation to Newly Diagnosed Type 2 Diabetic Patients with Depression |
title_full_unstemmed | Leucocyte Telomere Shortening in relation to Newly Diagnosed Type 2 Diabetic Patients with Depression |
title_short | Leucocyte Telomere Shortening in relation to Newly Diagnosed Type 2 Diabetic Patients with Depression |
title_sort | leucocyte telomere shortening in relation to newly diagnosed type 2 diabetic patients with depression |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020220/ https://www.ncbi.nlm.nih.gov/pubmed/24868316 http://dx.doi.org/10.1155/2014/673959 |
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