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Leucocyte Telomere Shortening in relation to Newly Diagnosed Type 2 Diabetic Patients with Depression

The goal of this study is to investigate the association between oxidative stress and telomere length shortening in the comorbid depression and diabetes. Therefore, 71 patients with newly diagnosed type 2 diabetes (T2D) and 52 subjects with normal glycemic level (control, Ctrl) were enrolled. Depres...

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Autores principales: Liu, Zhelong, Zhang, Jianhua, Yan, Jiangtao, Wang, Yuping, Li, Yongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020220/
https://www.ncbi.nlm.nih.gov/pubmed/24868316
http://dx.doi.org/10.1155/2014/673959
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author Liu, Zhelong
Zhang, Jianhua
Yan, Jiangtao
Wang, Yuping
Li, Yongsheng
author_facet Liu, Zhelong
Zhang, Jianhua
Yan, Jiangtao
Wang, Yuping
Li, Yongsheng
author_sort Liu, Zhelong
collection PubMed
description The goal of this study is to investigate the association between oxidative stress and telomere length shortening in the comorbid depression and diabetes. Therefore, 71 patients with newly diagnosed type 2 diabetes (T2D) and 52 subjects with normal glycemic level (control, Ctrl) were enrolled. Depressive status was identified with the Depression Subscale of Hospital Anxiety and Depression Scale (HADS-D). Leukocyte telomere length ratio (T/S ratio) was determined with quantitative PCR. Oxidative stress status was evaluated with 8-hydroxy-desoxyguanosine (8-OHdG) assay kit. Some other biochemical blood testing was also performed. The data showed that T2D patients had higher proportion of depression evaluated by the HADS-D (x (2) = 4.196, P = 0.041). T/S ratio was significantly negatively correlated with 8-OHdG, HADS-D, age, HbA1c, FPG, and HOMA-IR. In addition, HADS-D was significantly positively correlated with HbA1c, FPG, HOMA-IR, and 8-OHdG. Both HADS-D and 8-OHdG were the major independent predictors for T/S ratio. This study indicates that oxidative stress contributes to both telomere length shortening and depression development in newly diagnosed type 2 diabetic patients, while in depression status, some other mechanisms besides oxidative stress may also affect the telomere length.
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spelling pubmed-40202202014-05-27 Leucocyte Telomere Shortening in relation to Newly Diagnosed Type 2 Diabetic Patients with Depression Liu, Zhelong Zhang, Jianhua Yan, Jiangtao Wang, Yuping Li, Yongsheng Oxid Med Cell Longev Research Article The goal of this study is to investigate the association between oxidative stress and telomere length shortening in the comorbid depression and diabetes. Therefore, 71 patients with newly diagnosed type 2 diabetes (T2D) and 52 subjects with normal glycemic level (control, Ctrl) were enrolled. Depressive status was identified with the Depression Subscale of Hospital Anxiety and Depression Scale (HADS-D). Leukocyte telomere length ratio (T/S ratio) was determined with quantitative PCR. Oxidative stress status was evaluated with 8-hydroxy-desoxyguanosine (8-OHdG) assay kit. Some other biochemical blood testing was also performed. The data showed that T2D patients had higher proportion of depression evaluated by the HADS-D (x (2) = 4.196, P = 0.041). T/S ratio was significantly negatively correlated with 8-OHdG, HADS-D, age, HbA1c, FPG, and HOMA-IR. In addition, HADS-D was significantly positively correlated with HbA1c, FPG, HOMA-IR, and 8-OHdG. Both HADS-D and 8-OHdG were the major independent predictors for T/S ratio. This study indicates that oxidative stress contributes to both telomere length shortening and depression development in newly diagnosed type 2 diabetic patients, while in depression status, some other mechanisms besides oxidative stress may also affect the telomere length. Hindawi Publishing Corporation 2014 2014-04-29 /pmc/articles/PMC4020220/ /pubmed/24868316 http://dx.doi.org/10.1155/2014/673959 Text en Copyright © 2014 Zhelong Liu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liu, Zhelong
Zhang, Jianhua
Yan, Jiangtao
Wang, Yuping
Li, Yongsheng
Leucocyte Telomere Shortening in relation to Newly Diagnosed Type 2 Diabetic Patients with Depression
title Leucocyte Telomere Shortening in relation to Newly Diagnosed Type 2 Diabetic Patients with Depression
title_full Leucocyte Telomere Shortening in relation to Newly Diagnosed Type 2 Diabetic Patients with Depression
title_fullStr Leucocyte Telomere Shortening in relation to Newly Diagnosed Type 2 Diabetic Patients with Depression
title_full_unstemmed Leucocyte Telomere Shortening in relation to Newly Diagnosed Type 2 Diabetic Patients with Depression
title_short Leucocyte Telomere Shortening in relation to Newly Diagnosed Type 2 Diabetic Patients with Depression
title_sort leucocyte telomere shortening in relation to newly diagnosed type 2 diabetic patients with depression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020220/
https://www.ncbi.nlm.nih.gov/pubmed/24868316
http://dx.doi.org/10.1155/2014/673959
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