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Distribution of the Matsuda Index in Japanese healthy subjects

We investigated the cut‐off point of the Matsuda Index in Japanese according to the guideline from the Clinical and Laboratory Standards Institute. A total of 1,596 subjects free from medications for diabetes mellitus, dyslipidemia and/or hypertension, and without cardiovascular diseases or chronic...

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Autores principales: Takahara, Mitsuyoshi, Katakami, Naoto, Kaneto, Hideaki, Noguchi, Midori, Shimomura, Iichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley-Blackwell 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020231/
https://www.ncbi.nlm.nih.gov/pubmed/24843681
http://dx.doi.org/10.1111/jdi.12056
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author Takahara, Mitsuyoshi
Katakami, Naoto
Kaneto, Hideaki
Noguchi, Midori
Shimomura, Iichiro
author_facet Takahara, Mitsuyoshi
Katakami, Naoto
Kaneto, Hideaki
Noguchi, Midori
Shimomura, Iichiro
author_sort Takahara, Mitsuyoshi
collection PubMed
description We investigated the cut‐off point of the Matsuda Index in Japanese according to the guideline from the Clinical and Laboratory Standards Institute. A total of 1,596 subjects free from medications for diabetes mellitus, dyslipidemia and/or hypertension, and without cardiovascular diseases or chronic renal failure underwent a health check‐up and oral glucose tolerance test (OGTT). We recruited 204 healthy reference individuals with normal glucose tolerance without obesity, any component of metabolic syndrome or elevated alanine aminotransferase. The Matsuda Index was calculated with 0‐ and 120‐min data during OGTT. As the index was not normally distributed (P < 0.001 by the Shapiro–Wilk test), the log‐transformed value (P = 0.876 by the Shapiro–Wilk test) was used. The mean ± 2 standard deviations were taken as the reference limits. The lower reference limit of the Matsuda Index was then calculated to be 4.3. Our result shows that a Matsuda Index <4.3 indicates the presence of insulin resistance in Japanese.
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spelling pubmed-40202312014-05-19 Distribution of the Matsuda Index in Japanese healthy subjects Takahara, Mitsuyoshi Katakami, Naoto Kaneto, Hideaki Noguchi, Midori Shimomura, Iichiro J Diabetes Investig Articles We investigated the cut‐off point of the Matsuda Index in Japanese according to the guideline from the Clinical and Laboratory Standards Institute. A total of 1,596 subjects free from medications for diabetes mellitus, dyslipidemia and/or hypertension, and without cardiovascular diseases or chronic renal failure underwent a health check‐up and oral glucose tolerance test (OGTT). We recruited 204 healthy reference individuals with normal glucose tolerance without obesity, any component of metabolic syndrome or elevated alanine aminotransferase. The Matsuda Index was calculated with 0‐ and 120‐min data during OGTT. As the index was not normally distributed (P < 0.001 by the Shapiro–Wilk test), the log‐transformed value (P = 0.876 by the Shapiro–Wilk test) was used. The mean ± 2 standard deviations were taken as the reference limits. The lower reference limit of the Matsuda Index was then calculated to be 4.3. Our result shows that a Matsuda Index <4.3 indicates the presence of insulin resistance in Japanese. Wiley-Blackwell 2013-02-27 2013-07-08 /pmc/articles/PMC4020231/ /pubmed/24843681 http://dx.doi.org/10.1111/jdi.12056 Text en Copyright © 2013 Asian Association for the Study of Diabetes and Wiley Publishing Asia Pty Ltd
spellingShingle Articles
Takahara, Mitsuyoshi
Katakami, Naoto
Kaneto, Hideaki
Noguchi, Midori
Shimomura, Iichiro
Distribution of the Matsuda Index in Japanese healthy subjects
title Distribution of the Matsuda Index in Japanese healthy subjects
title_full Distribution of the Matsuda Index in Japanese healthy subjects
title_fullStr Distribution of the Matsuda Index in Japanese healthy subjects
title_full_unstemmed Distribution of the Matsuda Index in Japanese healthy subjects
title_short Distribution of the Matsuda Index in Japanese healthy subjects
title_sort distribution of the matsuda index in japanese healthy subjects
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020231/
https://www.ncbi.nlm.nih.gov/pubmed/24843681
http://dx.doi.org/10.1111/jdi.12056
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