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Aging of the CD4 T Cell Compartment
Higher morbidity and mortality following infections, particularly influenza, is observed in the elderly population. Because of this, people over 65 years old are often targeted for preventive immunization. Many vaccines, however, are not as effective in generating protective antibodies in older indi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020238/ https://www.ncbi.nlm.nih.gov/pubmed/24839469 http://dx.doi.org/10.2174/1876326X01206010083 |
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author | Lefebvre, Julie S Haynes, Laura |
author_facet | Lefebvre, Julie S Haynes, Laura |
author_sort | Lefebvre, Julie S |
collection | PubMed |
description | Higher morbidity and mortality following infections, particularly influenza, is observed in the elderly population. Because of this, people over 65 years old are often targeted for preventive immunization. Many vaccines, however, are not as effective in generating protective antibodies in older individuals. CD4(+) T cells, through their B cell helper functions, play a central role in the humoral response. Aging has deleterious effects on the immune system, and understanding how aging impairs CD4(+) T cell functions is of critical importance to design new immunization and treatment strategies targeted to the elderly population. In this paper, we review some of the qualitative and quantitative changes in the CD4(+) T cell compartment that arise with aging. We also summarize the age-related intrinsic defects that impact naïve, memory and regulatory CD4(+) T cell functions. |
format | Online Article Text |
id | pubmed-4020238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
record_format | MEDLINE/PubMed |
spelling | pubmed-40202382014-05-14 Aging of the CD4 T Cell Compartment Lefebvre, Julie S Haynes, Laura Open Longev Sci Article Higher morbidity and mortality following infections, particularly influenza, is observed in the elderly population. Because of this, people over 65 years old are often targeted for preventive immunization. Many vaccines, however, are not as effective in generating protective antibodies in older individuals. CD4(+) T cells, through their B cell helper functions, play a central role in the humoral response. Aging has deleterious effects on the immune system, and understanding how aging impairs CD4(+) T cell functions is of critical importance to design new immunization and treatment strategies targeted to the elderly population. In this paper, we review some of the qualitative and quantitative changes in the CD4(+) T cell compartment that arise with aging. We also summarize the age-related intrinsic defects that impact naïve, memory and regulatory CD4(+) T cell functions. 2012-01-01 /pmc/articles/PMC4020238/ /pubmed/24839469 http://dx.doi.org/10.2174/1876326X01206010083 Text en © Lefebvre and Haynes; http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Lefebvre, Julie S Haynes, Laura Aging of the CD4 T Cell Compartment |
title | Aging of the CD4 T Cell Compartment |
title_full | Aging of the CD4 T Cell Compartment |
title_fullStr | Aging of the CD4 T Cell Compartment |
title_full_unstemmed | Aging of the CD4 T Cell Compartment |
title_short | Aging of the CD4 T Cell Compartment |
title_sort | aging of the cd4 t cell compartment |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020238/ https://www.ncbi.nlm.nih.gov/pubmed/24839469 http://dx.doi.org/10.2174/1876326X01206010083 |
work_keys_str_mv | AT lefebvrejulies agingofthecd4tcellcompartment AT hayneslaura agingofthecd4tcellcompartment |