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H3K4 demethylase activities repress proliferative and postmitotic aging

Homeostasis of postmitotic and proliferating cells is maintained by pathways that repress stress. We found that the Caenorhabditis elegans histone 3 lysine 4 (H3K4) demethylases RBR-2 and SPR-5 promoted postmitotic longevity of stress-resistant daf-2 adults, altered pools of methylated H3K4, and pro...

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Autores principales: Alvares, Stacy M, Mayberry, Gaea A, Joyner, Ebony Y, Lakowski, Bernard, Ahmed, Shawn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020274/
https://www.ncbi.nlm.nih.gov/pubmed/24134677
http://dx.doi.org/10.1111/acel.12166
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author Alvares, Stacy M
Mayberry, Gaea A
Joyner, Ebony Y
Lakowski, Bernard
Ahmed, Shawn
author_facet Alvares, Stacy M
Mayberry, Gaea A
Joyner, Ebony Y
Lakowski, Bernard
Ahmed, Shawn
author_sort Alvares, Stacy M
collection PubMed
description Homeostasis of postmitotic and proliferating cells is maintained by pathways that repress stress. We found that the Caenorhabditis elegans histone 3 lysine 4 (H3K4) demethylases RBR-2 and SPR-5 promoted postmitotic longevity of stress-resistant daf-2 adults, altered pools of methylated H3K4, and promoted silencing of some daf-2 target genes. In addition, RBR-2 and SPR-5 were required for germ cell immortality at a high temperature. Transgenerational proliferative aging was enhanced for spr-5; rbr-2 double mutants, suggesting that these histone demethylases may function sequentially to promote germ cell immortality by targeting distinct H3K4 methyl marks. RBR-2 did not play a comparable role in the maintenance of quiescent germ cells in dauer larvae, implying that it represses stress that occurs as a consequence of germ cell proliferation, rather than stress that accumulates in nondividing cells. We propose that H3K4 demethylase activities promote the maintenance of chromatin states during stressful growth conditions, thereby repressing postmitotic aging of somatic cells as well as proliferative aging of germ cells.
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spelling pubmed-40202742015-02-19 H3K4 demethylase activities repress proliferative and postmitotic aging Alvares, Stacy M Mayberry, Gaea A Joyner, Ebony Y Lakowski, Bernard Ahmed, Shawn Aging Cell Original Articles Homeostasis of postmitotic and proliferating cells is maintained by pathways that repress stress. We found that the Caenorhabditis elegans histone 3 lysine 4 (H3K4) demethylases RBR-2 and SPR-5 promoted postmitotic longevity of stress-resistant daf-2 adults, altered pools of methylated H3K4, and promoted silencing of some daf-2 target genes. In addition, RBR-2 and SPR-5 were required for germ cell immortality at a high temperature. Transgenerational proliferative aging was enhanced for spr-5; rbr-2 double mutants, suggesting that these histone demethylases may function sequentially to promote germ cell immortality by targeting distinct H3K4 methyl marks. RBR-2 did not play a comparable role in the maintenance of quiescent germ cells in dauer larvae, implying that it represses stress that occurs as a consequence of germ cell proliferation, rather than stress that accumulates in nondividing cells. We propose that H3K4 demethylase activities promote the maintenance of chromatin states during stressful growth conditions, thereby repressing postmitotic aging of somatic cells as well as proliferative aging of germ cells. BlackWell Publishing Ltd 2014-04 2013-11-19 /pmc/articles/PMC4020274/ /pubmed/24134677 http://dx.doi.org/10.1111/acel.12166 Text en © 2013 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Alvares, Stacy M
Mayberry, Gaea A
Joyner, Ebony Y
Lakowski, Bernard
Ahmed, Shawn
H3K4 demethylase activities repress proliferative and postmitotic aging
title H3K4 demethylase activities repress proliferative and postmitotic aging
title_full H3K4 demethylase activities repress proliferative and postmitotic aging
title_fullStr H3K4 demethylase activities repress proliferative and postmitotic aging
title_full_unstemmed H3K4 demethylase activities repress proliferative and postmitotic aging
title_short H3K4 demethylase activities repress proliferative and postmitotic aging
title_sort h3k4 demethylase activities repress proliferative and postmitotic aging
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020274/
https://www.ncbi.nlm.nih.gov/pubmed/24134677
http://dx.doi.org/10.1111/acel.12166
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