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Lipid Peroxidation in Psychiatric Illness: Overview of Clinical Evidence
The brain is known to be sensitive to oxidative stress and lipid peroxidation. While lipid peroxidation has been shown to contribute to many disease processes, its role in psychiatric illness has not been investigated until recently. In this paper, we provide an overview of lipid peroxidation in the...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020299/ https://www.ncbi.nlm.nih.gov/pubmed/24868318 http://dx.doi.org/10.1155/2014/828702 |
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author | Joshi, Yash B. Praticò, Domenico |
author_facet | Joshi, Yash B. Praticò, Domenico |
author_sort | Joshi, Yash B. |
collection | PubMed |
description | The brain is known to be sensitive to oxidative stress and lipid peroxidation. While lipid peroxidation has been shown to contribute to many disease processes, its role in psychiatric illness has not been investigated until recently. In this paper, we provide an overview of lipid peroxidation in the central nervous system as well as clinical data supporting a link between lipid peroxidation and disorders such as schizophrenia, bipolar disorder, and major depressive disorder. These data support further investigation of lipid peroxidation in the effort to uncover therapeutic targets and biomarkers of psychiatric disease. |
format | Online Article Text |
id | pubmed-4020299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40202992014-05-27 Lipid Peroxidation in Psychiatric Illness: Overview of Clinical Evidence Joshi, Yash B. Praticò, Domenico Oxid Med Cell Longev Review Article The brain is known to be sensitive to oxidative stress and lipid peroxidation. While lipid peroxidation has been shown to contribute to many disease processes, its role in psychiatric illness has not been investigated until recently. In this paper, we provide an overview of lipid peroxidation in the central nervous system as well as clinical data supporting a link between lipid peroxidation and disorders such as schizophrenia, bipolar disorder, and major depressive disorder. These data support further investigation of lipid peroxidation in the effort to uncover therapeutic targets and biomarkers of psychiatric disease. Hindawi Publishing Corporation 2014 2014-04-27 /pmc/articles/PMC4020299/ /pubmed/24868318 http://dx.doi.org/10.1155/2014/828702 Text en Copyright © 2014 Y. B. Joshi and D. Praticò. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Joshi, Yash B. Praticò, Domenico Lipid Peroxidation in Psychiatric Illness: Overview of Clinical Evidence |
title | Lipid Peroxidation in Psychiatric Illness: Overview of Clinical Evidence |
title_full | Lipid Peroxidation in Psychiatric Illness: Overview of Clinical Evidence |
title_fullStr | Lipid Peroxidation in Psychiatric Illness: Overview of Clinical Evidence |
title_full_unstemmed | Lipid Peroxidation in Psychiatric Illness: Overview of Clinical Evidence |
title_short | Lipid Peroxidation in Psychiatric Illness: Overview of Clinical Evidence |
title_sort | lipid peroxidation in psychiatric illness: overview of clinical evidence |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020299/ https://www.ncbi.nlm.nih.gov/pubmed/24868318 http://dx.doi.org/10.1155/2014/828702 |
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