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Lipid Peroxidation in Psychiatric Illness: Overview of Clinical Evidence

The brain is known to be sensitive to oxidative stress and lipid peroxidation. While lipid peroxidation has been shown to contribute to many disease processes, its role in psychiatric illness has not been investigated until recently. In this paper, we provide an overview of lipid peroxidation in the...

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Detalles Bibliográficos
Autores principales: Joshi, Yash B., Praticò, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020299/
https://www.ncbi.nlm.nih.gov/pubmed/24868318
http://dx.doi.org/10.1155/2014/828702
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author Joshi, Yash B.
Praticò, Domenico
author_facet Joshi, Yash B.
Praticò, Domenico
author_sort Joshi, Yash B.
collection PubMed
description The brain is known to be sensitive to oxidative stress and lipid peroxidation. While lipid peroxidation has been shown to contribute to many disease processes, its role in psychiatric illness has not been investigated until recently. In this paper, we provide an overview of lipid peroxidation in the central nervous system as well as clinical data supporting a link between lipid peroxidation and disorders such as schizophrenia, bipolar disorder, and major depressive disorder. These data support further investigation of lipid peroxidation in the effort to uncover therapeutic targets and biomarkers of psychiatric disease.
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spelling pubmed-40202992014-05-27 Lipid Peroxidation in Psychiatric Illness: Overview of Clinical Evidence Joshi, Yash B. Praticò, Domenico Oxid Med Cell Longev Review Article The brain is known to be sensitive to oxidative stress and lipid peroxidation. While lipid peroxidation has been shown to contribute to many disease processes, its role in psychiatric illness has not been investigated until recently. In this paper, we provide an overview of lipid peroxidation in the central nervous system as well as clinical data supporting a link between lipid peroxidation and disorders such as schizophrenia, bipolar disorder, and major depressive disorder. These data support further investigation of lipid peroxidation in the effort to uncover therapeutic targets and biomarkers of psychiatric disease. Hindawi Publishing Corporation 2014 2014-04-27 /pmc/articles/PMC4020299/ /pubmed/24868318 http://dx.doi.org/10.1155/2014/828702 Text en Copyright © 2014 Y. B. Joshi and D. Praticò. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Joshi, Yash B.
Praticò, Domenico
Lipid Peroxidation in Psychiatric Illness: Overview of Clinical Evidence
title Lipid Peroxidation in Psychiatric Illness: Overview of Clinical Evidence
title_full Lipid Peroxidation in Psychiatric Illness: Overview of Clinical Evidence
title_fullStr Lipid Peroxidation in Psychiatric Illness: Overview of Clinical Evidence
title_full_unstemmed Lipid Peroxidation in Psychiatric Illness: Overview of Clinical Evidence
title_short Lipid Peroxidation in Psychiatric Illness: Overview of Clinical Evidence
title_sort lipid peroxidation in psychiatric illness: overview of clinical evidence
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020299/
https://www.ncbi.nlm.nih.gov/pubmed/24868318
http://dx.doi.org/10.1155/2014/828702
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