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A portrait of single and multiple HPV type infections in Brazilian women of different age strata with squamous or glandular cervical lesions

BACKGROUND: Cervical cancer ranks third in prevalence and fourth as cause of death in women worldwide. In Brazil, 17,540 women were diagnosed in 2012 with the disease. Persistent infection with high-risk HPV types is a necessary condition for the development of pre-invasive and invasive cervical neo...

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Autores principales: Resende, Leandro Santos de Araújo, Rabelo-Santos, Sílvia Helena, Sarian, Luís Otávio, Alves, Rosane Ribeiro Figueiredo, Ribeiro, Andréa Alves, Zeferino, Luiz Carlos, Derchain, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020319/
https://www.ncbi.nlm.nih.gov/pubmed/24751127
http://dx.doi.org/10.1186/1471-2334-14-214
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author Resende, Leandro Santos de Araújo
Rabelo-Santos, Sílvia Helena
Sarian, Luís Otávio
Alves, Rosane Ribeiro Figueiredo
Ribeiro, Andréa Alves
Zeferino, Luiz Carlos
Derchain, Sophie
author_facet Resende, Leandro Santos de Araújo
Rabelo-Santos, Sílvia Helena
Sarian, Luís Otávio
Alves, Rosane Ribeiro Figueiredo
Ribeiro, Andréa Alves
Zeferino, Luiz Carlos
Derchain, Sophie
author_sort Resende, Leandro Santos de Araújo
collection PubMed
description BACKGROUND: Cervical cancer ranks third in prevalence and fourth as cause of death in women worldwide. In Brazil, 17,540 women were diagnosed in 2012 with the disease. Persistent infection with high-risk HPV types is a necessary condition for the development of pre-invasive and invasive cervical neoplasia. Currently, over 100 HPV types have been identified, but HPV16 and 18 are recognized as the mayor culprits in cervical carcinogenesis. Our objective was to assess the relationships between single- (ST) and multiple-type (MT) HPV infections with patients’ age and lesion pathological status. METHODS: 328 patients with either squamous or glandular intraepithelial or invasive cervical lesion were selected. All subjects were tested for HPV genotypes with reverse hybridization for 21 high- (hr-HPV) and 16 low-risk (lr-HPV) probes. Prevalence of ST and MT HPV infections was compared across histological types and age strata. RESULTS: 287 (87%) women had at least one HPV type detected and 149 (52%) had MT infections. The most prevalent HPV type was HPV16, present in 142 cases (49% of all HPV-positive cases), followed by HPV58, 52, 31, 35 and 33. HPV18, in single or multiple infections, occurred in 23 cases (8% of hr-HPV cases). Almost all glandular lesions were associated with HPV16 and 18 alone. Multiple infections were significantly more prevalent in squamous than in glandular lesion for HPV16 and 18 (P = 0.04 and 0.03 respectively). The prevalence of MT infections followed a bimodal distribution; peaking in women younger 29 years and in those aged 50 to 59. CONCLUSIONS: Our data indicate that prevention strategies for pre-invasive and invasive squamous lesions should be focused on HPV16 and a few alpha-9 HPV types. It is clear to us that in young women, prophylaxis must cover a large amalgam of HPV types beyond classic HPV16 and 18.
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spelling pubmed-40203192014-05-15 A portrait of single and multiple HPV type infections in Brazilian women of different age strata with squamous or glandular cervical lesions Resende, Leandro Santos de Araújo Rabelo-Santos, Sílvia Helena Sarian, Luís Otávio Alves, Rosane Ribeiro Figueiredo Ribeiro, Andréa Alves Zeferino, Luiz Carlos Derchain, Sophie BMC Infect Dis Research Article BACKGROUND: Cervical cancer ranks third in prevalence and fourth as cause of death in women worldwide. In Brazil, 17,540 women were diagnosed in 2012 with the disease. Persistent infection with high-risk HPV types is a necessary condition for the development of pre-invasive and invasive cervical neoplasia. Currently, over 100 HPV types have been identified, but HPV16 and 18 are recognized as the mayor culprits in cervical carcinogenesis. Our objective was to assess the relationships between single- (ST) and multiple-type (MT) HPV infections with patients’ age and lesion pathological status. METHODS: 328 patients with either squamous or glandular intraepithelial or invasive cervical lesion were selected. All subjects were tested for HPV genotypes with reverse hybridization for 21 high- (hr-HPV) and 16 low-risk (lr-HPV) probes. Prevalence of ST and MT HPV infections was compared across histological types and age strata. RESULTS: 287 (87%) women had at least one HPV type detected and 149 (52%) had MT infections. The most prevalent HPV type was HPV16, present in 142 cases (49% of all HPV-positive cases), followed by HPV58, 52, 31, 35 and 33. HPV18, in single or multiple infections, occurred in 23 cases (8% of hr-HPV cases). Almost all glandular lesions were associated with HPV16 and 18 alone. Multiple infections were significantly more prevalent in squamous than in glandular lesion for HPV16 and 18 (P = 0.04 and 0.03 respectively). The prevalence of MT infections followed a bimodal distribution; peaking in women younger 29 years and in those aged 50 to 59. CONCLUSIONS: Our data indicate that prevention strategies for pre-invasive and invasive squamous lesions should be focused on HPV16 and a few alpha-9 HPV types. It is clear to us that in young women, prophylaxis must cover a large amalgam of HPV types beyond classic HPV16 and 18. BioMed Central 2014-04-22 /pmc/articles/PMC4020319/ /pubmed/24751127 http://dx.doi.org/10.1186/1471-2334-14-214 Text en Copyright © 2014 Resende et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research Article
Resende, Leandro Santos de Araújo
Rabelo-Santos, Sílvia Helena
Sarian, Luís Otávio
Alves, Rosane Ribeiro Figueiredo
Ribeiro, Andréa Alves
Zeferino, Luiz Carlos
Derchain, Sophie
A portrait of single and multiple HPV type infections in Brazilian women of different age strata with squamous or glandular cervical lesions
title A portrait of single and multiple HPV type infections in Brazilian women of different age strata with squamous or glandular cervical lesions
title_full A portrait of single and multiple HPV type infections in Brazilian women of different age strata with squamous or glandular cervical lesions
title_fullStr A portrait of single and multiple HPV type infections in Brazilian women of different age strata with squamous or glandular cervical lesions
title_full_unstemmed A portrait of single and multiple HPV type infections in Brazilian women of different age strata with squamous or glandular cervical lesions
title_short A portrait of single and multiple HPV type infections in Brazilian women of different age strata with squamous or glandular cervical lesions
title_sort portrait of single and multiple hpv type infections in brazilian women of different age strata with squamous or glandular cervical lesions
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020319/
https://www.ncbi.nlm.nih.gov/pubmed/24751127
http://dx.doi.org/10.1186/1471-2334-14-214
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