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Fasting serum insulin levels and insulin resistance are associated with colorectal adenoma in Koreans

AIMS/INTRODUCTION: Insulin has been associated with the risk of colorectal cancer (CRC). However, few studies have evaluated the association between insulin and colorectal adenoma. We investigated the relationship between fasting serum insulin levels or homeostasis model assessment of insulin resist...

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Autores principales: Kim, Eun Hee, Kim, Hong‐Kyu, Bae, Sung Jin, Chang, Hye‐Sook, Park, Hye Won, Do, Mi Young, Kim, Kyung‐Jo, Jung, Chang Hee, Lee, Woo Je, Park, Joong‐Yeol, Choe, Jaewon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley-Blackwell 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020334/
https://www.ncbi.nlm.nih.gov/pubmed/24843778
http://dx.doi.org/10.1111/jdi.12178
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author Kim, Eun Hee
Kim, Hong‐Kyu
Bae, Sung Jin
Chang, Hye‐Sook
Park, Hye Won
Do, Mi Young
Kim, Kyung‐Jo
Jung, Chang Hee
Lee, Woo Je
Park, Joong‐Yeol
Choe, Jaewon
author_facet Kim, Eun Hee
Kim, Hong‐Kyu
Bae, Sung Jin
Chang, Hye‐Sook
Park, Hye Won
Do, Mi Young
Kim, Kyung‐Jo
Jung, Chang Hee
Lee, Woo Je
Park, Joong‐Yeol
Choe, Jaewon
author_sort Kim, Eun Hee
collection PubMed
description AIMS/INTRODUCTION: Insulin has been associated with the risk of colorectal cancer (CRC). However, few studies have evaluated the association between insulin and colorectal adenoma. We investigated the relationship between fasting serum insulin levels or homeostasis model assessment of insulin resistance (HOMA‐IR) and colorectal adenoma. MATERIALS AND METHODS: We retrospectively enrolled 15,427 participants who underwent both fasting serum insulin measurement and colonoscopy for a routine health examination at Asan Medical Center from January 2007 to December 2008. Participants with a history of any cancer, previous colectomy or polypectomy, those taking antidiabetic medications, and inflammatory bowel disease, non‐specific colitis, non‐adenomatous polyps only or CRC on colonoscopic findings were excluded. Finally, 3,606 participants with histologically confirmed colorectal adenoma and 6,019 controls with no abnormal findings on colonoscopy were included. Participants were categorized into quartiles (Q) based on fasting serum insulin levels and HOMA‐IR. RESULTS: Fasting serum insulin and HOMA‐IR were significantly higher in participants with colorectal adenomas compared with controls. Multivariate regression analysis adjusting for age, sex, smoking habits, drinking habits and family history of CRC showed that participants with higher quartiles of fasting serum insulin levels (odd ratio [OR] 1.17 for 2nd Q, 1.19 for 3rd Q, and 1.42 for 4th Q, P < 0.05) or HOMA‐IR (OR 1.18 for 2nd Q and 1.45 for 4th Q, P < 0.05) showed significantly increased ORs of colorectal adenoma compared with the lowest quartiles. CONCLUSIONS: These findings showed that increased serum insulin levels and insulin resistance were significantly associated with the presence of colorectal adenoma.
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spelling pubmed-40203342014-05-19 Fasting serum insulin levels and insulin resistance are associated with colorectal adenoma in Koreans Kim, Eun Hee Kim, Hong‐Kyu Bae, Sung Jin Chang, Hye‐Sook Park, Hye Won Do, Mi Young Kim, Kyung‐Jo Jung, Chang Hee Lee, Woo Je Park, Joong‐Yeol Choe, Jaewon J Diabetes Investig Articles AIMS/INTRODUCTION: Insulin has been associated with the risk of colorectal cancer (CRC). However, few studies have evaluated the association between insulin and colorectal adenoma. We investigated the relationship between fasting serum insulin levels or homeostasis model assessment of insulin resistance (HOMA‐IR) and colorectal adenoma. MATERIALS AND METHODS: We retrospectively enrolled 15,427 participants who underwent both fasting serum insulin measurement and colonoscopy for a routine health examination at Asan Medical Center from January 2007 to December 2008. Participants with a history of any cancer, previous colectomy or polypectomy, those taking antidiabetic medications, and inflammatory bowel disease, non‐specific colitis, non‐adenomatous polyps only or CRC on colonoscopic findings were excluded. Finally, 3,606 participants with histologically confirmed colorectal adenoma and 6,019 controls with no abnormal findings on colonoscopy were included. Participants were categorized into quartiles (Q) based on fasting serum insulin levels and HOMA‐IR. RESULTS: Fasting serum insulin and HOMA‐IR were significantly higher in participants with colorectal adenomas compared with controls. Multivariate regression analysis adjusting for age, sex, smoking habits, drinking habits and family history of CRC showed that participants with higher quartiles of fasting serum insulin levels (odd ratio [OR] 1.17 for 2nd Q, 1.19 for 3rd Q, and 1.42 for 4th Q, P < 0.05) or HOMA‐IR (OR 1.18 for 2nd Q and 1.45 for 4th Q, P < 0.05) showed significantly increased ORs of colorectal adenoma compared with the lowest quartiles. CONCLUSIONS: These findings showed that increased serum insulin levels and insulin resistance were significantly associated with the presence of colorectal adenoma. Wiley-Blackwell 2013-12-05 2014-05-04 /pmc/articles/PMC4020334/ /pubmed/24843778 http://dx.doi.org/10.1111/jdi.12178 Text en Copyright © 2014 Asian Association for the Study of Diabetes and Wiley Publishing Asia Pty Ltd This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Articles
Kim, Eun Hee
Kim, Hong‐Kyu
Bae, Sung Jin
Chang, Hye‐Sook
Park, Hye Won
Do, Mi Young
Kim, Kyung‐Jo
Jung, Chang Hee
Lee, Woo Je
Park, Joong‐Yeol
Choe, Jaewon
Fasting serum insulin levels and insulin resistance are associated with colorectal adenoma in Koreans
title Fasting serum insulin levels and insulin resistance are associated with colorectal adenoma in Koreans
title_full Fasting serum insulin levels and insulin resistance are associated with colorectal adenoma in Koreans
title_fullStr Fasting serum insulin levels and insulin resistance are associated with colorectal adenoma in Koreans
title_full_unstemmed Fasting serum insulin levels and insulin resistance are associated with colorectal adenoma in Koreans
title_short Fasting serum insulin levels and insulin resistance are associated with colorectal adenoma in Koreans
title_sort fasting serum insulin levels and insulin resistance are associated with colorectal adenoma in koreans
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020334/
https://www.ncbi.nlm.nih.gov/pubmed/24843778
http://dx.doi.org/10.1111/jdi.12178
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