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Protective Effect of Ligustrazine on Lumbar Intervertebral Disc Degeneration of Rats Induced by Prolonged Upright Posture

Most chronic low back pain is the result of degeneration of the lumbar intervertebral disc. Ligustrazine, an alkaloid from Chuanxiong, reportedly is able to relieve pain, suppress inflammation, and treat osteoarthritis and it has the protective effect on cartilage and chondrocytes. Therefore, we ask...

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Autores principales: Liang, Qian-Qian, Ding, Dao-Fang, Xi, Zhi-Jie, Chen, Yan, Li, Chen-Guang, Liu, Shu-Fen, Lu, Sheng, Zhao, Yong-Jian, Shi, Qi, Wang, Yong-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020374/
https://www.ncbi.nlm.nih.gov/pubmed/24872832
http://dx.doi.org/10.1155/2014/508461
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author Liang, Qian-Qian
Ding, Dao-Fang
Xi, Zhi-Jie
Chen, Yan
Li, Chen-Guang
Liu, Shu-Fen
Lu, Sheng
Zhao, Yong-Jian
Shi, Qi
Wang, Yong-Jun
author_facet Liang, Qian-Qian
Ding, Dao-Fang
Xi, Zhi-Jie
Chen, Yan
Li, Chen-Guang
Liu, Shu-Fen
Lu, Sheng
Zhao, Yong-Jian
Shi, Qi
Wang, Yong-Jun
author_sort Liang, Qian-Qian
collection PubMed
description Most chronic low back pain is the result of degeneration of the lumbar intervertebral disc. Ligustrazine, an alkaloid from Chuanxiong, reportedly is able to relieve pain, suppress inflammation, and treat osteoarthritis and it has the protective effect on cartilage and chondrocytes. Therefore, we asked whether ligustrazine could reduce intervertebral disc degeneration. To determine the effect of ligustrazine on disc degeneration, we applied a rat model. The intervertebral disc degeneration of the rats was induced by prolonged upright posture. We found that pretreatment with ligustrazine for 1 month recovered the structural distortion of the degenerative disc; inhibited the expression of type X collagen, matrix metalloproteinase (MMP)-13, and MMP3; upregulated type II collagen; and decreased IL-1β, cyclooxygenase (COX)-2, and inducible nitric oxide synthase (iNOS) expression. In conclusion, ligustrazine is a promising agent for treating lumbar intervertebral disc degeneration disease.
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spelling pubmed-40203742014-05-28 Protective Effect of Ligustrazine on Lumbar Intervertebral Disc Degeneration of Rats Induced by Prolonged Upright Posture Liang, Qian-Qian Ding, Dao-Fang Xi, Zhi-Jie Chen, Yan Li, Chen-Guang Liu, Shu-Fen Lu, Sheng Zhao, Yong-Jian Shi, Qi Wang, Yong-Jun Evid Based Complement Alternat Med Research Article Most chronic low back pain is the result of degeneration of the lumbar intervertebral disc. Ligustrazine, an alkaloid from Chuanxiong, reportedly is able to relieve pain, suppress inflammation, and treat osteoarthritis and it has the protective effect on cartilage and chondrocytes. Therefore, we asked whether ligustrazine could reduce intervertebral disc degeneration. To determine the effect of ligustrazine on disc degeneration, we applied a rat model. The intervertebral disc degeneration of the rats was induced by prolonged upright posture. We found that pretreatment with ligustrazine for 1 month recovered the structural distortion of the degenerative disc; inhibited the expression of type X collagen, matrix metalloproteinase (MMP)-13, and MMP3; upregulated type II collagen; and decreased IL-1β, cyclooxygenase (COX)-2, and inducible nitric oxide synthase (iNOS) expression. In conclusion, ligustrazine is a promising agent for treating lumbar intervertebral disc degeneration disease. Hindawi Publishing Corporation 2014 2014-04-29 /pmc/articles/PMC4020374/ /pubmed/24872832 http://dx.doi.org/10.1155/2014/508461 Text en Copyright © 2014 Qian-Qian Liang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liang, Qian-Qian
Ding, Dao-Fang
Xi, Zhi-Jie
Chen, Yan
Li, Chen-Guang
Liu, Shu-Fen
Lu, Sheng
Zhao, Yong-Jian
Shi, Qi
Wang, Yong-Jun
Protective Effect of Ligustrazine on Lumbar Intervertebral Disc Degeneration of Rats Induced by Prolonged Upright Posture
title Protective Effect of Ligustrazine on Lumbar Intervertebral Disc Degeneration of Rats Induced by Prolonged Upright Posture
title_full Protective Effect of Ligustrazine on Lumbar Intervertebral Disc Degeneration of Rats Induced by Prolonged Upright Posture
title_fullStr Protective Effect of Ligustrazine on Lumbar Intervertebral Disc Degeneration of Rats Induced by Prolonged Upright Posture
title_full_unstemmed Protective Effect of Ligustrazine on Lumbar Intervertebral Disc Degeneration of Rats Induced by Prolonged Upright Posture
title_short Protective Effect of Ligustrazine on Lumbar Intervertebral Disc Degeneration of Rats Induced by Prolonged Upright Posture
title_sort protective effect of ligustrazine on lumbar intervertebral disc degeneration of rats induced by prolonged upright posture
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020374/
https://www.ncbi.nlm.nih.gov/pubmed/24872832
http://dx.doi.org/10.1155/2014/508461
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