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Protective Effect of Ligustrazine on Lumbar Intervertebral Disc Degeneration of Rats Induced by Prolonged Upright Posture
Most chronic low back pain is the result of degeneration of the lumbar intervertebral disc. Ligustrazine, an alkaloid from Chuanxiong, reportedly is able to relieve pain, suppress inflammation, and treat osteoarthritis and it has the protective effect on cartilage and chondrocytes. Therefore, we ask...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020374/ https://www.ncbi.nlm.nih.gov/pubmed/24872832 http://dx.doi.org/10.1155/2014/508461 |
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author | Liang, Qian-Qian Ding, Dao-Fang Xi, Zhi-Jie Chen, Yan Li, Chen-Guang Liu, Shu-Fen Lu, Sheng Zhao, Yong-Jian Shi, Qi Wang, Yong-Jun |
author_facet | Liang, Qian-Qian Ding, Dao-Fang Xi, Zhi-Jie Chen, Yan Li, Chen-Guang Liu, Shu-Fen Lu, Sheng Zhao, Yong-Jian Shi, Qi Wang, Yong-Jun |
author_sort | Liang, Qian-Qian |
collection | PubMed |
description | Most chronic low back pain is the result of degeneration of the lumbar intervertebral disc. Ligustrazine, an alkaloid from Chuanxiong, reportedly is able to relieve pain, suppress inflammation, and treat osteoarthritis and it has the protective effect on cartilage and chondrocytes. Therefore, we asked whether ligustrazine could reduce intervertebral disc degeneration. To determine the effect of ligustrazine on disc degeneration, we applied a rat model. The intervertebral disc degeneration of the rats was induced by prolonged upright posture. We found that pretreatment with ligustrazine for 1 month recovered the structural distortion of the degenerative disc; inhibited the expression of type X collagen, matrix metalloproteinase (MMP)-13, and MMP3; upregulated type II collagen; and decreased IL-1β, cyclooxygenase (COX)-2, and inducible nitric oxide synthase (iNOS) expression. In conclusion, ligustrazine is a promising agent for treating lumbar intervertebral disc degeneration disease. |
format | Online Article Text |
id | pubmed-4020374 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40203742014-05-28 Protective Effect of Ligustrazine on Lumbar Intervertebral Disc Degeneration of Rats Induced by Prolonged Upright Posture Liang, Qian-Qian Ding, Dao-Fang Xi, Zhi-Jie Chen, Yan Li, Chen-Guang Liu, Shu-Fen Lu, Sheng Zhao, Yong-Jian Shi, Qi Wang, Yong-Jun Evid Based Complement Alternat Med Research Article Most chronic low back pain is the result of degeneration of the lumbar intervertebral disc. Ligustrazine, an alkaloid from Chuanxiong, reportedly is able to relieve pain, suppress inflammation, and treat osteoarthritis and it has the protective effect on cartilage and chondrocytes. Therefore, we asked whether ligustrazine could reduce intervertebral disc degeneration. To determine the effect of ligustrazine on disc degeneration, we applied a rat model. The intervertebral disc degeneration of the rats was induced by prolonged upright posture. We found that pretreatment with ligustrazine for 1 month recovered the structural distortion of the degenerative disc; inhibited the expression of type X collagen, matrix metalloproteinase (MMP)-13, and MMP3; upregulated type II collagen; and decreased IL-1β, cyclooxygenase (COX)-2, and inducible nitric oxide synthase (iNOS) expression. In conclusion, ligustrazine is a promising agent for treating lumbar intervertebral disc degeneration disease. Hindawi Publishing Corporation 2014 2014-04-29 /pmc/articles/PMC4020374/ /pubmed/24872832 http://dx.doi.org/10.1155/2014/508461 Text en Copyright © 2014 Qian-Qian Liang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Liang, Qian-Qian Ding, Dao-Fang Xi, Zhi-Jie Chen, Yan Li, Chen-Guang Liu, Shu-Fen Lu, Sheng Zhao, Yong-Jian Shi, Qi Wang, Yong-Jun Protective Effect of Ligustrazine on Lumbar Intervertebral Disc Degeneration of Rats Induced by Prolonged Upright Posture |
title | Protective Effect of Ligustrazine on Lumbar Intervertebral Disc Degeneration of Rats Induced by Prolonged Upright Posture |
title_full | Protective Effect of Ligustrazine on Lumbar Intervertebral Disc Degeneration of Rats Induced by Prolonged Upright Posture |
title_fullStr | Protective Effect of Ligustrazine on Lumbar Intervertebral Disc Degeneration of Rats Induced by Prolonged Upright Posture |
title_full_unstemmed | Protective Effect of Ligustrazine on Lumbar Intervertebral Disc Degeneration of Rats Induced by Prolonged Upright Posture |
title_short | Protective Effect of Ligustrazine on Lumbar Intervertebral Disc Degeneration of Rats Induced by Prolonged Upright Posture |
title_sort | protective effect of ligustrazine on lumbar intervertebral disc degeneration of rats induced by prolonged upright posture |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020374/ https://www.ncbi.nlm.nih.gov/pubmed/24872832 http://dx.doi.org/10.1155/2014/508461 |
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