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Probiotics in the Treatment of Chronic Rhinoconjunctivitis and Chronic Rhinosinusitis

Chronic rhinitis and rhinosinusitis (CRS) are relevant health conditions affecting significant percentages of the western population. They are frequently coexisting and aggravating diseases. Both are chronic, noninfectious, and inflammatory conditions sharing to a certain extent important pathophysi...

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Autores principales: Kramer, Matthias F., Heath, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020448/
https://www.ncbi.nlm.nih.gov/pubmed/24872820
http://dx.doi.org/10.1155/2014/983635
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author Kramer, Matthias F.
Heath, Matthew D.
author_facet Kramer, Matthias F.
Heath, Matthew D.
author_sort Kramer, Matthias F.
collection PubMed
description Chronic rhinitis and rhinosinusitis (CRS) are relevant health conditions affecting significant percentages of the western population. They are frequently coexisting and aggravating diseases. Both are chronic, noninfectious, and inflammatory conditions sharing to a certain extent important pathophysiologic similarities. Beneficial effects of probiotics are long known to mankind. Research is beginning to unravel the true nature of the human microbiome and its interaction with the immune system. The growing prevalence of atopic diseases in the developed world led to the proposition of the “hygiene hypothesis.” Dysbiosis is linked to atopic diseases; probiotic supplementation is able to alter the microbiome and certain probiotic strains have immunomodulatory effects in favour of a suppression of Th-2 and stimulation of a Th1 profile. This review focuses on randomized, double-blind, placebo-controlled trials investigating clinical parameters in the treatment of chronic rhinitis and CRS. An emerging number of publications demonstrate beneficial effects using probiotics in clinical double-blind placebo-controlled (dbpc) trials in allergic rhinitis (AR). Using probiotics as complementary treatment options in AR seems to be a promising concept although the evidence is of a preliminary nature to date and more convincing trials are needed. There are no current data to support the use of probiotics in non-AR or CRS.
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spelling pubmed-40204482014-05-28 Probiotics in the Treatment of Chronic Rhinoconjunctivitis and Chronic Rhinosinusitis Kramer, Matthias F. Heath, Matthew D. J Allergy (Cairo) Review Article Chronic rhinitis and rhinosinusitis (CRS) are relevant health conditions affecting significant percentages of the western population. They are frequently coexisting and aggravating diseases. Both are chronic, noninfectious, and inflammatory conditions sharing to a certain extent important pathophysiologic similarities. Beneficial effects of probiotics are long known to mankind. Research is beginning to unravel the true nature of the human microbiome and its interaction with the immune system. The growing prevalence of atopic diseases in the developed world led to the proposition of the “hygiene hypothesis.” Dysbiosis is linked to atopic diseases; probiotic supplementation is able to alter the microbiome and certain probiotic strains have immunomodulatory effects in favour of a suppression of Th-2 and stimulation of a Th1 profile. This review focuses on randomized, double-blind, placebo-controlled trials investigating clinical parameters in the treatment of chronic rhinitis and CRS. An emerging number of publications demonstrate beneficial effects using probiotics in clinical double-blind placebo-controlled (dbpc) trials in allergic rhinitis (AR). Using probiotics as complementary treatment options in AR seems to be a promising concept although the evidence is of a preliminary nature to date and more convincing trials are needed. There are no current data to support the use of probiotics in non-AR or CRS. Hindawi Publishing Corporation 2014 2014-04-28 /pmc/articles/PMC4020448/ /pubmed/24872820 http://dx.doi.org/10.1155/2014/983635 Text en Copyright © 2014 M. F. Kramer and M. D. Heath. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kramer, Matthias F.
Heath, Matthew D.
Probiotics in the Treatment of Chronic Rhinoconjunctivitis and Chronic Rhinosinusitis
title Probiotics in the Treatment of Chronic Rhinoconjunctivitis and Chronic Rhinosinusitis
title_full Probiotics in the Treatment of Chronic Rhinoconjunctivitis and Chronic Rhinosinusitis
title_fullStr Probiotics in the Treatment of Chronic Rhinoconjunctivitis and Chronic Rhinosinusitis
title_full_unstemmed Probiotics in the Treatment of Chronic Rhinoconjunctivitis and Chronic Rhinosinusitis
title_short Probiotics in the Treatment of Chronic Rhinoconjunctivitis and Chronic Rhinosinusitis
title_sort probiotics in the treatment of chronic rhinoconjunctivitis and chronic rhinosinusitis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020448/
https://www.ncbi.nlm.nih.gov/pubmed/24872820
http://dx.doi.org/10.1155/2014/983635
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