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Assembly Line Polyketide Synthases: Mechanistic Insights and Unsolved Problems

[Image: see text] Two hallmarks of assembly line polyketide synthases have motivated an interest in these unusual multienzyme systems, their stereospecificity and their capacity for directional biosynthesis. In this review, we summarize the state of knowledge regarding the mechanistic origins of the...

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Detalles Bibliográficos
Autores principales: Khosla, Chaitan, Herschlag, Daniel, Cane, David E., Walsh, Christopher T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020578/
https://www.ncbi.nlm.nih.gov/pubmed/24779441
http://dx.doi.org/10.1021/bi500290t