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Modification, Biological Evaluation and 3D QSAR Studies of Novel 2-(1,3-Diaryl- 4,5-Dihydro-1H-Pyrazol-5-yl)Phenol Derivatives as Inhibitors of B-Raf Kinase

A series of novel 2-(1,3-diaryl- 4,5-dihydro-1H-pyrazol-5-yl)phenol derivatives (C1–C24) have been synthesized. The B-Raf inhibitory activity and anti-proliferation activity of these compounds have been tested. Compound C6 displayed the most potent biological activity against B-Raf(V600E) (IC(50) = ...

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Detalles Bibliográficos
Autores principales:	Yang, Yu-Shun, Zhang, Fei, Tang, Dan-Jie, Yang, Yong-Hua, Zhu, Hai-Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020744/ https://www.ncbi.nlm.nih.gov/pubmed/24827980 http://dx.doi.org/10.1371/journal.pone.0095702

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