Differential Effects of CSF-1R D802V and KIT D816V Homologous Mutations on Receptor Tertiary Structure and Allosteric Communication

The colony stimulating factor-1 receptor (CSF-1R) and the stem cell factor receptor KIT, type III receptor tyrosine kinases (RTKs), are important mediators of signal transduction. The normal functions of these receptors can be compromised by gain-of-function mutations associated with different physi...

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Detalles Bibliográficos
Autores principales: Da Silva Figueiredo Celestino Gomes, Priscila, Panel, Nicolas, Laine, Elodie, Pascutti, Pedro Geraldo, Solary, Eric, Tchertanov, Luba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020833/
https://www.ncbi.nlm.nih.gov/pubmed/24828813
http://dx.doi.org/10.1371/journal.pone.0097519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020833/
https://www.ncbi.nlm.nih.gov/pubmed/24828813
http://dx.doi.org/10.1371/journal.pone.0097519

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