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Differential Effects of CSF-1R D802V and KIT D816V Homologous Mutations on Receptor Tertiary Structure and Allosteric Communication
The colony stimulating factor-1 receptor (CSF-1R) and the stem cell factor receptor KIT, type III receptor tyrosine kinases (RTKs), are important mediators of signal transduction. The normal functions of these receptors can be compromised by gain-of-function mutations associated with different physi...
Autores principales: | Da Silva Figueiredo Celestino Gomes, Priscila, Panel, Nicolas, Laine, Elodie, Pascutti, Pedro Geraldo, Solary, Eric, Tchertanov, Luba |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020833/ https://www.ncbi.nlm.nih.gov/pubmed/24828813 http://dx.doi.org/10.1371/journal.pone.0097519 |
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