AAV-Mediated Delivery of Zinc Finger Nucleases Targeting Hepatitis B Virus Inhibits Active Replication

Despite an existing effective vaccine, hepatitis B virus (HBV) remains a major public health concern. There are effective suppressive therapies for HBV, but they remain expensive and inaccessible to many, and not all patients respond well. Furthermore, HBV can persist as genomic covalently closed ci...

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Detalles Bibliográficos
Autores principales: Weber, Nicholas D., Stone, Daniel, Sedlak, Ruth Hall, De Silva Feelixge, Harshana S., Roychoudhury, Pavitra, Schiffer, Joshua T., Aubert, Martine, Jerome, Keith R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020843/
https://www.ncbi.nlm.nih.gov/pubmed/24827459
http://dx.doi.org/10.1371/journal.pone.0097579

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