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Interstitial Cystitis – Elucidation of Psychophysiologic and Autonomic Characteristics (the ICEPAC Study): design and methods

BACKGROUND AND PURPOSE: Interstitial cystitis/bladder pain syndrome (IC/BPS) is relatively common and associated with severe pain, yet effective treatment remains elusive. Research typically emphasized the bladder’s role, but given the high presence of systemic comorbidities, the authors hypothesize...

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Autores principales: Chelimsky, Thomas, Chelimsky, Gisela, McCabe, N Patrick, Louttit, Megan, Hijaz, Adonis, Mahajan, Sangeeta, Sanses, Tatiana, Buffington, CA Tony, Fenton, Bradford, Janicki, Thomas, Ialacci, Sarah, Veizi, Elias, Zhang, Di, Daneshgari, Firouz, Elston, Robert, Janata, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020893/
https://www.ncbi.nlm.nih.gov/pubmed/24855387
http://dx.doi.org/10.2147/JPR.S58853
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author Chelimsky, Thomas
Chelimsky, Gisela
McCabe, N Patrick
Louttit, Megan
Hijaz, Adonis
Mahajan, Sangeeta
Sanses, Tatiana
Buffington, CA Tony
Fenton, Bradford
Janicki, Thomas
Ialacci, Sarah
Veizi, Elias
Zhang, Di
Daneshgari, Firouz
Elston, Robert
Janata, Jeffrey
author_facet Chelimsky, Thomas
Chelimsky, Gisela
McCabe, N Patrick
Louttit, Megan
Hijaz, Adonis
Mahajan, Sangeeta
Sanses, Tatiana
Buffington, CA Tony
Fenton, Bradford
Janicki, Thomas
Ialacci, Sarah
Veizi, Elias
Zhang, Di
Daneshgari, Firouz
Elston, Robert
Janata, Jeffrey
author_sort Chelimsky, Thomas
collection PubMed
description BACKGROUND AND PURPOSE: Interstitial cystitis/bladder pain syndrome (IC/BPS) is relatively common and associated with severe pain, yet effective treatment remains elusive. Research typically emphasized the bladder’s role, but given the high presence of systemic comorbidities, the authors hypothesized a pathophysiologic nervous system role. This paper reports the methodology and approach to study the nervous system in women with IC/BPS. The study compares neurologic, urologic, gynecologic, autonomic, gastrointestinal, and psychological features of women with IC/BPS, their female relatives, women with myofascial pelvic pain (MPP), and healthy controls to elucidate the role of central and peripheral processing. METHODS AND RESULTS: In total, 228 women (76 IC/BPS, 76 MPP, 38 family members, and 38 healthy controls) will be recruited. Subjects undergo detailed screening, structured neurologic examination of limbs and pelvis, tender point examination, autonomic testing, electrogastrography, and assessment of comorbid functional dysautonomias. Interpreters are blinded to subject classification. Psychological and stress response characteristics are examined with assessments of stress, trauma history, general psychological function, and stress response quantification. As of December 2012, data collection is completed for 25 healthy controls, 33 IC/BPS ± MPP, eight MPP, and three family members. Recruitment rate is accelerating and strategies emphasize maintaining and encouraging investigator participation in study science, internet advertising, and presentations to pelvic pain support groups. CONCLUSION: The study represents a comprehensive, interdisciplinary approach to sampling autonomic and psychophysiologic characteristics of women with IC/BPS. Despite divergent opinions on study methodologies based on specialty experiences, the study has proven feasible to date and different perspectives have proved to be one of the greatest study strengths.
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spelling pubmed-40208932014-05-22 Interstitial Cystitis – Elucidation of Psychophysiologic and Autonomic Characteristics (the ICEPAC Study): design and methods Chelimsky, Thomas Chelimsky, Gisela McCabe, N Patrick Louttit, Megan Hijaz, Adonis Mahajan, Sangeeta Sanses, Tatiana Buffington, CA Tony Fenton, Bradford Janicki, Thomas Ialacci, Sarah Veizi, Elias Zhang, Di Daneshgari, Firouz Elston, Robert Janata, Jeffrey J Pain Res Methodology BACKGROUND AND PURPOSE: Interstitial cystitis/bladder pain syndrome (IC/BPS) is relatively common and associated with severe pain, yet effective treatment remains elusive. Research typically emphasized the bladder’s role, but given the high presence of systemic comorbidities, the authors hypothesized a pathophysiologic nervous system role. This paper reports the methodology and approach to study the nervous system in women with IC/BPS. The study compares neurologic, urologic, gynecologic, autonomic, gastrointestinal, and psychological features of women with IC/BPS, their female relatives, women with myofascial pelvic pain (MPP), and healthy controls to elucidate the role of central and peripheral processing. METHODS AND RESULTS: In total, 228 women (76 IC/BPS, 76 MPP, 38 family members, and 38 healthy controls) will be recruited. Subjects undergo detailed screening, structured neurologic examination of limbs and pelvis, tender point examination, autonomic testing, electrogastrography, and assessment of comorbid functional dysautonomias. Interpreters are blinded to subject classification. Psychological and stress response characteristics are examined with assessments of stress, trauma history, general psychological function, and stress response quantification. As of December 2012, data collection is completed for 25 healthy controls, 33 IC/BPS ± MPP, eight MPP, and three family members. Recruitment rate is accelerating and strategies emphasize maintaining and encouraging investigator participation in study science, internet advertising, and presentations to pelvic pain support groups. CONCLUSION: The study represents a comprehensive, interdisciplinary approach to sampling autonomic and psychophysiologic characteristics of women with IC/BPS. Despite divergent opinions on study methodologies based on specialty experiences, the study has proven feasible to date and different perspectives have proved to be one of the greatest study strengths. Dove Medical Press 2014-05-08 /pmc/articles/PMC4020893/ /pubmed/24855387 http://dx.doi.org/10.2147/JPR.S58853 Text en © 2014 Chelimsky et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Methodology
Chelimsky, Thomas
Chelimsky, Gisela
McCabe, N Patrick
Louttit, Megan
Hijaz, Adonis
Mahajan, Sangeeta
Sanses, Tatiana
Buffington, CA Tony
Fenton, Bradford
Janicki, Thomas
Ialacci, Sarah
Veizi, Elias
Zhang, Di
Daneshgari, Firouz
Elston, Robert
Janata, Jeffrey
Interstitial Cystitis – Elucidation of Psychophysiologic and Autonomic Characteristics (the ICEPAC Study): design and methods
title Interstitial Cystitis – Elucidation of Psychophysiologic and Autonomic Characteristics (the ICEPAC Study): design and methods
title_full Interstitial Cystitis – Elucidation of Psychophysiologic and Autonomic Characteristics (the ICEPAC Study): design and methods
title_fullStr Interstitial Cystitis – Elucidation of Psychophysiologic and Autonomic Characteristics (the ICEPAC Study): design and methods
title_full_unstemmed Interstitial Cystitis – Elucidation of Psychophysiologic and Autonomic Characteristics (the ICEPAC Study): design and methods
title_short Interstitial Cystitis – Elucidation of Psychophysiologic and Autonomic Characteristics (the ICEPAC Study): design and methods
title_sort interstitial cystitis – elucidation of psychophysiologic and autonomic characteristics (the icepac study): design and methods
topic Methodology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020893/
https://www.ncbi.nlm.nih.gov/pubmed/24855387
http://dx.doi.org/10.2147/JPR.S58853
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