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Interstitial Cystitis – Elucidation of Psychophysiologic and Autonomic Characteristics (the ICEPAC Study): design and methods
BACKGROUND AND PURPOSE: Interstitial cystitis/bladder pain syndrome (IC/BPS) is relatively common and associated with severe pain, yet effective treatment remains elusive. Research typically emphasized the bladder’s role, but given the high presence of systemic comorbidities, the authors hypothesize...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020893/ https://www.ncbi.nlm.nih.gov/pubmed/24855387 http://dx.doi.org/10.2147/JPR.S58853 |
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author | Chelimsky, Thomas Chelimsky, Gisela McCabe, N Patrick Louttit, Megan Hijaz, Adonis Mahajan, Sangeeta Sanses, Tatiana Buffington, CA Tony Fenton, Bradford Janicki, Thomas Ialacci, Sarah Veizi, Elias Zhang, Di Daneshgari, Firouz Elston, Robert Janata, Jeffrey |
author_facet | Chelimsky, Thomas Chelimsky, Gisela McCabe, N Patrick Louttit, Megan Hijaz, Adonis Mahajan, Sangeeta Sanses, Tatiana Buffington, CA Tony Fenton, Bradford Janicki, Thomas Ialacci, Sarah Veizi, Elias Zhang, Di Daneshgari, Firouz Elston, Robert Janata, Jeffrey |
author_sort | Chelimsky, Thomas |
collection | PubMed |
description | BACKGROUND AND PURPOSE: Interstitial cystitis/bladder pain syndrome (IC/BPS) is relatively common and associated with severe pain, yet effective treatment remains elusive. Research typically emphasized the bladder’s role, but given the high presence of systemic comorbidities, the authors hypothesized a pathophysiologic nervous system role. This paper reports the methodology and approach to study the nervous system in women with IC/BPS. The study compares neurologic, urologic, gynecologic, autonomic, gastrointestinal, and psychological features of women with IC/BPS, their female relatives, women with myofascial pelvic pain (MPP), and healthy controls to elucidate the role of central and peripheral processing. METHODS AND RESULTS: In total, 228 women (76 IC/BPS, 76 MPP, 38 family members, and 38 healthy controls) will be recruited. Subjects undergo detailed screening, structured neurologic examination of limbs and pelvis, tender point examination, autonomic testing, electrogastrography, and assessment of comorbid functional dysautonomias. Interpreters are blinded to subject classification. Psychological and stress response characteristics are examined with assessments of stress, trauma history, general psychological function, and stress response quantification. As of December 2012, data collection is completed for 25 healthy controls, 33 IC/BPS ± MPP, eight MPP, and three family members. Recruitment rate is accelerating and strategies emphasize maintaining and encouraging investigator participation in study science, internet advertising, and presentations to pelvic pain support groups. CONCLUSION: The study represents a comprehensive, interdisciplinary approach to sampling autonomic and psychophysiologic characteristics of women with IC/BPS. Despite divergent opinions on study methodologies based on specialty experiences, the study has proven feasible to date and different perspectives have proved to be one of the greatest study strengths. |
format | Online Article Text |
id | pubmed-4020893 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-40208932014-05-22 Interstitial Cystitis – Elucidation of Psychophysiologic and Autonomic Characteristics (the ICEPAC Study): design and methods Chelimsky, Thomas Chelimsky, Gisela McCabe, N Patrick Louttit, Megan Hijaz, Adonis Mahajan, Sangeeta Sanses, Tatiana Buffington, CA Tony Fenton, Bradford Janicki, Thomas Ialacci, Sarah Veizi, Elias Zhang, Di Daneshgari, Firouz Elston, Robert Janata, Jeffrey J Pain Res Methodology BACKGROUND AND PURPOSE: Interstitial cystitis/bladder pain syndrome (IC/BPS) is relatively common and associated with severe pain, yet effective treatment remains elusive. Research typically emphasized the bladder’s role, but given the high presence of systemic comorbidities, the authors hypothesized a pathophysiologic nervous system role. This paper reports the methodology and approach to study the nervous system in women with IC/BPS. The study compares neurologic, urologic, gynecologic, autonomic, gastrointestinal, and psychological features of women with IC/BPS, their female relatives, women with myofascial pelvic pain (MPP), and healthy controls to elucidate the role of central and peripheral processing. METHODS AND RESULTS: In total, 228 women (76 IC/BPS, 76 MPP, 38 family members, and 38 healthy controls) will be recruited. Subjects undergo detailed screening, structured neurologic examination of limbs and pelvis, tender point examination, autonomic testing, electrogastrography, and assessment of comorbid functional dysautonomias. Interpreters are blinded to subject classification. Psychological and stress response characteristics are examined with assessments of stress, trauma history, general psychological function, and stress response quantification. As of December 2012, data collection is completed for 25 healthy controls, 33 IC/BPS ± MPP, eight MPP, and three family members. Recruitment rate is accelerating and strategies emphasize maintaining and encouraging investigator participation in study science, internet advertising, and presentations to pelvic pain support groups. CONCLUSION: The study represents a comprehensive, interdisciplinary approach to sampling autonomic and psychophysiologic characteristics of women with IC/BPS. Despite divergent opinions on study methodologies based on specialty experiences, the study has proven feasible to date and different perspectives have proved to be one of the greatest study strengths. Dove Medical Press 2014-05-08 /pmc/articles/PMC4020893/ /pubmed/24855387 http://dx.doi.org/10.2147/JPR.S58853 Text en © 2014 Chelimsky et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Methodology Chelimsky, Thomas Chelimsky, Gisela McCabe, N Patrick Louttit, Megan Hijaz, Adonis Mahajan, Sangeeta Sanses, Tatiana Buffington, CA Tony Fenton, Bradford Janicki, Thomas Ialacci, Sarah Veizi, Elias Zhang, Di Daneshgari, Firouz Elston, Robert Janata, Jeffrey Interstitial Cystitis – Elucidation of Psychophysiologic and Autonomic Characteristics (the ICEPAC Study): design and methods |
title | Interstitial Cystitis – Elucidation of Psychophysiologic and Autonomic Characteristics (the ICEPAC Study): design and methods |
title_full | Interstitial Cystitis – Elucidation of Psychophysiologic and Autonomic Characteristics (the ICEPAC Study): design and methods |
title_fullStr | Interstitial Cystitis – Elucidation of Psychophysiologic and Autonomic Characteristics (the ICEPAC Study): design and methods |
title_full_unstemmed | Interstitial Cystitis – Elucidation of Psychophysiologic and Autonomic Characteristics (the ICEPAC Study): design and methods |
title_short | Interstitial Cystitis – Elucidation of Psychophysiologic and Autonomic Characteristics (the ICEPAC Study): design and methods |
title_sort | interstitial cystitis – elucidation of psychophysiologic and autonomic characteristics (the icepac study): design and methods |
topic | Methodology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020893/ https://www.ncbi.nlm.nih.gov/pubmed/24855387 http://dx.doi.org/10.2147/JPR.S58853 |
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