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Reduced fibulin-2 contributes to loss of basement membrane integrity and skin blistering in mice lacking integrin α3β1 in the epidermis
Deficient epidermal adhesion is a hallmark of blistering skin disorders and chronic wounds, implicating integrins as potential therapeutic targets. Integrin α3β1, a major receptor in epidermis for adhesion to laminin-332, plays critical roles in basement membrane organization during skin development...
Autores principales: | Longmate, Whitney M., Monichan, Ruby, Chu, Mon-Li, Tsuda, Takeshi, Mahoney, My G., DiPersio, C. Michael |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020984/ https://www.ncbi.nlm.nih.gov/pubmed/24390135 http://dx.doi.org/10.1038/jid.2014.10 |
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