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Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover

BACKGROUND: The transcription factor GATA3 is a favorable prognostic indicator in estrogen receptor-α (ERα)-positive breast tumors in which it participates with ERα and FOXA1 in a complex transcriptional regulatory program driving tumor growth. GATA3 mutations are frequent in breast cancer and have...

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Detalles Bibliográficos
Autores principales:	Adomas, Aleksandra B, Grimm, Sara A, Malone, Christine, Takaku, Motoki, Sims, Jennifer K, Wade, Paul A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021073/ https://www.ncbi.nlm.nih.gov/pubmed/24758297 http://dx.doi.org/10.1186/1471-2407-14-278

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