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Longterm follow-up in European respiratory health studies – patterns and implications
BACKGROUND: Selection bias is a systematic error in epidemiologic studies that may seriously distort true measures of associations between exposure and disease. Observational studies are highly susceptible to selection bias, and researchers should therefore always examine to what extent selection bi...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021078/ https://www.ncbi.nlm.nih.gov/pubmed/24739530 http://dx.doi.org/10.1186/1471-2466-14-63 |
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author | Johannessen, Ane Verlato, Giuseppe Benediktsdottir, Bryndis Forsberg, Bertil Franklin, Karl Gislason, Thorarinn Holm, Mathias Janson, Christer Jögi, Rain Lindberg, Eva Macsali, Ferenc Omenaas, Ernst Real, Francisco Gomez Saure, Eirunn Waatevik Schlünssen, Vivi Sigsgaard, Torben Skorge, Trude Duelien Svanes, Cecilie Torén, Kjell Waatevik, Marie Nilsen, Roy Miodini de Marco, Roberto |
author_facet | Johannessen, Ane Verlato, Giuseppe Benediktsdottir, Bryndis Forsberg, Bertil Franklin, Karl Gislason, Thorarinn Holm, Mathias Janson, Christer Jögi, Rain Lindberg, Eva Macsali, Ferenc Omenaas, Ernst Real, Francisco Gomez Saure, Eirunn Waatevik Schlünssen, Vivi Sigsgaard, Torben Skorge, Trude Duelien Svanes, Cecilie Torén, Kjell Waatevik, Marie Nilsen, Roy Miodini de Marco, Roberto |
author_sort | Johannessen, Ane |
collection | PubMed |
description | BACKGROUND: Selection bias is a systematic error in epidemiologic studies that may seriously distort true measures of associations between exposure and disease. Observational studies are highly susceptible to selection bias, and researchers should therefore always examine to what extent selection bias may be present in their material and what characterizes the bias in their material. In the present study we examined long-term participation and consequences of loss to follow-up in the studies Respiratory Health in Northern Europe (RHINE), Italian centers of European Community Respiratory Health Survey (I-ECRHS), and the Italian Study on Asthma in Young Adults (ISAYA). METHODS: Logistic regression identified predictors for follow-up participation. Baseline prevalence of 9 respiratory symptoms (asthma attack, asthma medication, combined variable with asthma attack and/or asthma medication, wheeze, rhinitis, wheeze with dyspnea, wheeze without cold, waking with chest tightness, waking with dyspnea) and 9 exposure-outcome associations (predictors sex, age and smoking; outcomes wheeze, asthma and rhinitis) were compared between all baseline participants and long-term participants. Bias was measured as ratios of relative frequencies and ratios of odds ratios (ROR). RESULTS: Follow-up response rates after 10 years were 75% in RHINE, 64% in I-ECRHS and 53% in ISAYA. After 20 years of follow-up, response was 53% in RHINE and 49% in I-ECRHS. Female sex predicted long-term participation (in RHINE OR (95% CI) 1.30(1.22, 1.38); in I-ECRHS 1.29 (1.11, 1.50); and in ISAYA 1.42 (1.25, 1.61)), as did increasing age. Baseline prevalence of respiratory symptoms were lower among long-term participants (relative deviations compared to total baseline population 0-15% (RHINE), 0-48% (I-ECRHS), 3-20% (ISAYA)), except rhinitis which had a slightly higher prevalence. Most exposure-outcome associations did not differ between long-term participants and all baseline participants, except lower OR for rhinitis among ISAYA long-term participating smokers (relative deviation 17% (smokers) and 44% (10–20 pack years)). CONCLUSIONS: We found comparable patterns of long-term participation and loss to follow-up in RHINE, I-ECRHS and ISAYA. Baseline prevalence estimates for long-term participants were slightly lower than for the total baseline population, while exposure-outcome associations were mainly unchanged by loss to follow-up. |
format | Online Article Text |
id | pubmed-4021078 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40210782014-05-16 Longterm follow-up in European respiratory health studies – patterns and implications Johannessen, Ane Verlato, Giuseppe Benediktsdottir, Bryndis Forsberg, Bertil Franklin, Karl Gislason, Thorarinn Holm, Mathias Janson, Christer Jögi, Rain Lindberg, Eva Macsali, Ferenc Omenaas, Ernst Real, Francisco Gomez Saure, Eirunn Waatevik Schlünssen, Vivi Sigsgaard, Torben Skorge, Trude Duelien Svanes, Cecilie Torén, Kjell Waatevik, Marie Nilsen, Roy Miodini de Marco, Roberto BMC Pulm Med Research Article BACKGROUND: Selection bias is a systematic error in epidemiologic studies that may seriously distort true measures of associations between exposure and disease. Observational studies are highly susceptible to selection bias, and researchers should therefore always examine to what extent selection bias may be present in their material and what characterizes the bias in their material. In the present study we examined long-term participation and consequences of loss to follow-up in the studies Respiratory Health in Northern Europe (RHINE), Italian centers of European Community Respiratory Health Survey (I-ECRHS), and the Italian Study on Asthma in Young Adults (ISAYA). METHODS: Logistic regression identified predictors for follow-up participation. Baseline prevalence of 9 respiratory symptoms (asthma attack, asthma medication, combined variable with asthma attack and/or asthma medication, wheeze, rhinitis, wheeze with dyspnea, wheeze without cold, waking with chest tightness, waking with dyspnea) and 9 exposure-outcome associations (predictors sex, age and smoking; outcomes wheeze, asthma and rhinitis) were compared between all baseline participants and long-term participants. Bias was measured as ratios of relative frequencies and ratios of odds ratios (ROR). RESULTS: Follow-up response rates after 10 years were 75% in RHINE, 64% in I-ECRHS and 53% in ISAYA. After 20 years of follow-up, response was 53% in RHINE and 49% in I-ECRHS. Female sex predicted long-term participation (in RHINE OR (95% CI) 1.30(1.22, 1.38); in I-ECRHS 1.29 (1.11, 1.50); and in ISAYA 1.42 (1.25, 1.61)), as did increasing age. Baseline prevalence of respiratory symptoms were lower among long-term participants (relative deviations compared to total baseline population 0-15% (RHINE), 0-48% (I-ECRHS), 3-20% (ISAYA)), except rhinitis which had a slightly higher prevalence. Most exposure-outcome associations did not differ between long-term participants and all baseline participants, except lower OR for rhinitis among ISAYA long-term participating smokers (relative deviation 17% (smokers) and 44% (10–20 pack years)). CONCLUSIONS: We found comparable patterns of long-term participation and loss to follow-up in RHINE, I-ECRHS and ISAYA. Baseline prevalence estimates for long-term participants were slightly lower than for the total baseline population, while exposure-outcome associations were mainly unchanged by loss to follow-up. BioMed Central 2014-04-16 /pmc/articles/PMC4021078/ /pubmed/24739530 http://dx.doi.org/10.1186/1471-2466-14-63 Text en Copyright © 2014 Johannessen et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Johannessen, Ane Verlato, Giuseppe Benediktsdottir, Bryndis Forsberg, Bertil Franklin, Karl Gislason, Thorarinn Holm, Mathias Janson, Christer Jögi, Rain Lindberg, Eva Macsali, Ferenc Omenaas, Ernst Real, Francisco Gomez Saure, Eirunn Waatevik Schlünssen, Vivi Sigsgaard, Torben Skorge, Trude Duelien Svanes, Cecilie Torén, Kjell Waatevik, Marie Nilsen, Roy Miodini de Marco, Roberto Longterm follow-up in European respiratory health studies – patterns and implications |
title | Longterm follow-up in European respiratory health studies – patterns and implications |
title_full | Longterm follow-up in European respiratory health studies – patterns and implications |
title_fullStr | Longterm follow-up in European respiratory health studies – patterns and implications |
title_full_unstemmed | Longterm follow-up in European respiratory health studies – patterns and implications |
title_short | Longterm follow-up in European respiratory health studies – patterns and implications |
title_sort | longterm follow-up in european respiratory health studies – patterns and implications |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021078/ https://www.ncbi.nlm.nih.gov/pubmed/24739530 http://dx.doi.org/10.1186/1471-2466-14-63 |
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