Cisplatin-resistant cells in malignant pleural mesothelioma cell lines show ALDH(high)CD44(+) phenotype and sphere-forming capacity

BACKGROUND: Conventional chemotherapy in malignant pleural mesothelioma (MPM) has minimal impact on patient survival due to the supposed chemoresistance of cancer stem cells (CSCs). We sought to identify a sub-population of chemoresistant cells by using putative CSC markers, aldehyde dehydrogenase (...

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Detalles Bibliográficos
Autores principales: Cortes-Dericks, Lourdes, Froment, Laurene, Boesch, Ruben, Schmid, Ralph Alexander, Karoubi, Golnaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021184/
https://www.ncbi.nlm.nih.gov/pubmed/24884875
http://dx.doi.org/10.1186/1471-2407-14-304

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