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Evidence for significant influence of host immunity on changes in differential blood count during malaria
BACKGROUND: Malaria has been shown to change blood counts. Recently, a few studies have investigated the alteration of the peripheral blood monocyte-to-lymphocyte count ratio (MLCR) and the neutrophil-to-lymphocyte count ratio (NLCR) during infection with Plasmodium falciparum. Based on these findin...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021259/ https://www.ncbi.nlm.nih.gov/pubmed/24758172 http://dx.doi.org/10.1186/1475-2875-13-155 |
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author | Berens-Riha, Nicole Kroidl, Inge Schunk, Mirjam Alberer, Martin Beissner, Marcus Pritsch, Michael Kroidl, Arne Fröschl, Günter Hanus, Ingrid Bretzel, Gisela von Sonnenburg, Frank Nothdurft, Hans Dieter Löscher, Thomas Herbinger, Karl-Heinz |
author_facet | Berens-Riha, Nicole Kroidl, Inge Schunk, Mirjam Alberer, Martin Beissner, Marcus Pritsch, Michael Kroidl, Arne Fröschl, Günter Hanus, Ingrid Bretzel, Gisela von Sonnenburg, Frank Nothdurft, Hans Dieter Löscher, Thomas Herbinger, Karl-Heinz |
author_sort | Berens-Riha, Nicole |
collection | PubMed |
description | BACKGROUND: Malaria has been shown to change blood counts. Recently, a few studies have investigated the alteration of the peripheral blood monocyte-to-lymphocyte count ratio (MLCR) and the neutrophil-to-lymphocyte count ratio (NLCR) during infection with Plasmodium falciparum. Based on these findings this study investigates the predictive values of blood count alterations during malaria across different sub-populations. METHODS: Cases and controls admitted to the Department of Infectious Diseases and Tropical Medicine from January 2000 through December 2010 were included in this comparative analysis. Blood count values and other variables at admission controlled for age, gender and immune status were statistically investigated. RESULTS: The study population comprised 210 malaria patients, infected with P. falciparum (68%), Plasmodium vivax (21%), Plasmodium ovale (7%) and Plasmodium malariae (4%), and 210 controls. A positive correlation of parasite density with NLCR and neutrophil counts, and a negative correlation of parasite density with thrombocyte, leucocyte and lymphocyte counts were found. An interaction with semi-immunity was observed; ratios were significantly different in semi-immune compared to non-immune patients (P <0.001). The MLCR discriminated best between malaria cases and controls (AUC = 0.691; AUC = 0.741 in non-immune travellers), whereas the NLCR better predicted severe malaria, especially in semi-immune patients (AUC = 0.788). CONCLUSION: Malaria causes typical but non-specific alterations of the differential blood count. The predictive value of the ratios was fair but limited. However, these changes were less pronounced in patients with semi-immunity. The ratios might constitute easily applicable surrogate biomarkers for immunity. |
format | Online Article Text |
id | pubmed-4021259 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40212592014-05-16 Evidence for significant influence of host immunity on changes in differential blood count during malaria Berens-Riha, Nicole Kroidl, Inge Schunk, Mirjam Alberer, Martin Beissner, Marcus Pritsch, Michael Kroidl, Arne Fröschl, Günter Hanus, Ingrid Bretzel, Gisela von Sonnenburg, Frank Nothdurft, Hans Dieter Löscher, Thomas Herbinger, Karl-Heinz Malar J Research BACKGROUND: Malaria has been shown to change blood counts. Recently, a few studies have investigated the alteration of the peripheral blood monocyte-to-lymphocyte count ratio (MLCR) and the neutrophil-to-lymphocyte count ratio (NLCR) during infection with Plasmodium falciparum. Based on these findings this study investigates the predictive values of blood count alterations during malaria across different sub-populations. METHODS: Cases and controls admitted to the Department of Infectious Diseases and Tropical Medicine from January 2000 through December 2010 were included in this comparative analysis. Blood count values and other variables at admission controlled for age, gender and immune status were statistically investigated. RESULTS: The study population comprised 210 malaria patients, infected with P. falciparum (68%), Plasmodium vivax (21%), Plasmodium ovale (7%) and Plasmodium malariae (4%), and 210 controls. A positive correlation of parasite density with NLCR and neutrophil counts, and a negative correlation of parasite density with thrombocyte, leucocyte and lymphocyte counts were found. An interaction with semi-immunity was observed; ratios were significantly different in semi-immune compared to non-immune patients (P <0.001). The MLCR discriminated best between malaria cases and controls (AUC = 0.691; AUC = 0.741 in non-immune travellers), whereas the NLCR better predicted severe malaria, especially in semi-immune patients (AUC = 0.788). CONCLUSION: Malaria causes typical but non-specific alterations of the differential blood count. The predictive value of the ratios was fair but limited. However, these changes were less pronounced in patients with semi-immunity. The ratios might constitute easily applicable surrogate biomarkers for immunity. BioMed Central 2014-04-23 /pmc/articles/PMC4021259/ /pubmed/24758172 http://dx.doi.org/10.1186/1475-2875-13-155 Text en Copyright © 2014 Berens-Riha et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Berens-Riha, Nicole Kroidl, Inge Schunk, Mirjam Alberer, Martin Beissner, Marcus Pritsch, Michael Kroidl, Arne Fröschl, Günter Hanus, Ingrid Bretzel, Gisela von Sonnenburg, Frank Nothdurft, Hans Dieter Löscher, Thomas Herbinger, Karl-Heinz Evidence for significant influence of host immunity on changes in differential blood count during malaria |
title | Evidence for significant influence of host immunity on changes in differential blood count during malaria |
title_full | Evidence for significant influence of host immunity on changes in differential blood count during malaria |
title_fullStr | Evidence for significant influence of host immunity on changes in differential blood count during malaria |
title_full_unstemmed | Evidence for significant influence of host immunity on changes in differential blood count during malaria |
title_short | Evidence for significant influence of host immunity on changes in differential blood count during malaria |
title_sort | evidence for significant influence of host immunity on changes in differential blood count during malaria |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021259/ https://www.ncbi.nlm.nih.gov/pubmed/24758172 http://dx.doi.org/10.1186/1475-2875-13-155 |
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