The compensatory enrichment of sphingosine -1- phosphate harbored on glycated high-density lipoprotein restores endothelial protective function in type 2 diabetes mellitus

BACKGROUND: Glycation of high-density lipoprotein (HDL) decreases its ability to induce cyclooxygenase-2 (COX-2) expression and prostacyclin I-2 (PGI-2) release in endothelial cells. Whether lipid content of HDL, especially sphingosine-1-phosphate (S1P), plays any specific role in restoring the prot...

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Detalles Bibliográficos
Autores principales: Tong, Xunliang, Lv, Pu, Mathew, Anna V, Liu, Donghui, Niu, Chenguang, Wang, Yan, Ji, Liang, Li, Jizhao, Fu, Zhiwei, Pan, Bing, Pennathur, Subramaniam, Zheng, Lemin, Huang, Yining
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021293/
https://www.ncbi.nlm.nih.gov/pubmed/24751283
http://dx.doi.org/10.1186/1475-2840-13-82

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