The Role of Heat Shock Response in Insulin Resistance and Diabetes

The expansion of life-style related diseases, such as metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM), appears to be unstoppable. It is also difficult to cease their complications in spite of many antidiabetic medications or intervention of public administration. We and our collaborators...

Descripción completa

Detalles Bibliográficos
Autores principales: Kondo, Tatsuya, Motoshima, Hiroyuki, Igata, Motoyuki, Kawashima, Junji, Matsumura, Takeshi, Kai, Hirofumi, Araki, Eiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Diabetes Association 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021296/
https://www.ncbi.nlm.nih.gov/pubmed/24851203
http://dx.doi.org/10.4093/dmj.2014.38.2.100
_version_ 1782316213183971328
author Kondo, Tatsuya
Motoshima, Hiroyuki
Igata, Motoyuki
Kawashima, Junji
Matsumura, Takeshi
Kai, Hirofumi
Araki, Eiichi
author_facet Kondo, Tatsuya
Motoshima, Hiroyuki
Igata, Motoyuki
Kawashima, Junji
Matsumura, Takeshi
Kai, Hirofumi
Araki, Eiichi
author_sort Kondo, Tatsuya
collection PubMed
description The expansion of life-style related diseases, such as metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM), appears to be unstoppable. It is also difficult to cease their complications in spite of many antidiabetic medications or intervention of public administration. We and our collaborators found that physical medicine using simultaneous stimulation of heat with mild electric current activates heat shock response, thereby reducing visceral adiposity, insulin resistance, chronic inflammation and improving glucose homeostasis in mice models of T2DM, as well as in humans with MS or T2DM. This combination therapy exerts novel action on insulin signaling, β-cell protection and body compositions, and may provide a new therapeutic alternative in diabetic treatment strategy.
format Online
Article
Text
id pubmed-4021296
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Korean Diabetes Association
record_format MEDLINE/PubMed
spelling pubmed-40212962014-05-21 The Role of Heat Shock Response in Insulin Resistance and Diabetes Kondo, Tatsuya Motoshima, Hiroyuki Igata, Motoyuki Kawashima, Junji Matsumura, Takeshi Kai, Hirofumi Araki, Eiichi Diabetes Metab J Review The expansion of life-style related diseases, such as metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM), appears to be unstoppable. It is also difficult to cease their complications in spite of many antidiabetic medications or intervention of public administration. We and our collaborators found that physical medicine using simultaneous stimulation of heat with mild electric current activates heat shock response, thereby reducing visceral adiposity, insulin resistance, chronic inflammation and improving glucose homeostasis in mice models of T2DM, as well as in humans with MS or T2DM. This combination therapy exerts novel action on insulin signaling, β-cell protection and body compositions, and may provide a new therapeutic alternative in diabetic treatment strategy. Korean Diabetes Association 2014-04 2014-04-18 /pmc/articles/PMC4021296/ /pubmed/24851203 http://dx.doi.org/10.4093/dmj.2014.38.2.100 Text en Copyright © 2014 Korean Diabetes Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Kondo, Tatsuya
Motoshima, Hiroyuki
Igata, Motoyuki
Kawashima, Junji
Matsumura, Takeshi
Kai, Hirofumi
Araki, Eiichi
The Role of Heat Shock Response in Insulin Resistance and Diabetes
title The Role of Heat Shock Response in Insulin Resistance and Diabetes
title_full The Role of Heat Shock Response in Insulin Resistance and Diabetes
title_fullStr The Role of Heat Shock Response in Insulin Resistance and Diabetes
title_full_unstemmed The Role of Heat Shock Response in Insulin Resistance and Diabetes
title_short The Role of Heat Shock Response in Insulin Resistance and Diabetes
title_sort role of heat shock response in insulin resistance and diabetes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021296/
https://www.ncbi.nlm.nih.gov/pubmed/24851203
http://dx.doi.org/10.4093/dmj.2014.38.2.100
work_keys_str_mv AT kondotatsuya theroleofheatshockresponseininsulinresistanceanddiabetes
AT motoshimahiroyuki theroleofheatshockresponseininsulinresistanceanddiabetes
AT igatamotoyuki theroleofheatshockresponseininsulinresistanceanddiabetes
AT kawashimajunji theroleofheatshockresponseininsulinresistanceanddiabetes
AT matsumuratakeshi theroleofheatshockresponseininsulinresistanceanddiabetes
AT kaihirofumi theroleofheatshockresponseininsulinresistanceanddiabetes
AT arakieiichi theroleofheatshockresponseininsulinresistanceanddiabetes
AT kondotatsuya roleofheatshockresponseininsulinresistanceanddiabetes
AT motoshimahiroyuki roleofheatshockresponseininsulinresistanceanddiabetes
AT igatamotoyuki roleofheatshockresponseininsulinresistanceanddiabetes
AT kawashimajunji roleofheatshockresponseininsulinresistanceanddiabetes
AT matsumuratakeshi roleofheatshockresponseininsulinresistanceanddiabetes
AT kaihirofumi roleofheatshockresponseininsulinresistanceanddiabetes
AT arakieiichi roleofheatshockresponseininsulinresistanceanddiabetes

Ejemplares similares