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Subcellular mRNA localisation at a glance

mRNA localisation coupled to translational regulation provides an important means of dictating when and where proteins function in a variety of model systems. This mechanism is particularly relevant in polarised or migrating cells. Although many of the models for how this is achieved were first prop...

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Autores principales: Parton, Richard M., Davidson, Alexander, Davis, Ilan, Weil, Timothy T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021467/
https://www.ncbi.nlm.nih.gov/pubmed/24833669
http://dx.doi.org/10.1242/jcs.114272
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author Parton, Richard M.
Davidson, Alexander
Davis, Ilan
Weil, Timothy T.
author_facet Parton, Richard M.
Davidson, Alexander
Davis, Ilan
Weil, Timothy T.
author_sort Parton, Richard M.
collection PubMed
description mRNA localisation coupled to translational regulation provides an important means of dictating when and where proteins function in a variety of model systems. This mechanism is particularly relevant in polarised or migrating cells. Although many of the models for how this is achieved were first proposed over 20 years ago, some of the molecular details are still poorly understood. Nevertheless, advanced imaging, biochemical and computational approaches have started to shed light on the cis-acting localisation signals and trans-acting factors that dictate the final destination of localised transcripts. In this Cell Science at a Glance article and accompanying poster, we provide an overview of mRNA localisation, from transcription to degradation, focusing on the microtubule-dependent active transport and anchoring mechanism, which we will use to explain the general paradigm. However, it is clear that there are diverse ways in which mRNAs become localised and target protein expression, and we highlight some of the similarities and differences between these mechanisms.
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spelling pubmed-40214672014-06-12 Subcellular mRNA localisation at a glance Parton, Richard M. Davidson, Alexander Davis, Ilan Weil, Timothy T. J Cell Sci Cell Science at a Glance mRNA localisation coupled to translational regulation provides an important means of dictating when and where proteins function in a variety of model systems. This mechanism is particularly relevant in polarised or migrating cells. Although many of the models for how this is achieved were first proposed over 20 years ago, some of the molecular details are still poorly understood. Nevertheless, advanced imaging, biochemical and computational approaches have started to shed light on the cis-acting localisation signals and trans-acting factors that dictate the final destination of localised transcripts. In this Cell Science at a Glance article and accompanying poster, we provide an overview of mRNA localisation, from transcription to degradation, focusing on the microtubule-dependent active transport and anchoring mechanism, which we will use to explain the general paradigm. However, it is clear that there are diverse ways in which mRNAs become localised and target protein expression, and we highlight some of the similarities and differences between these mechanisms. The Company of Biologists 2014-05-15 /pmc/articles/PMC4021467/ /pubmed/24833669 http://dx.doi.org/10.1242/jcs.114272 Text en © 2014. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Cell Science at a Glance
Parton, Richard M.
Davidson, Alexander
Davis, Ilan
Weil, Timothy T.
Subcellular mRNA localisation at a glance
title Subcellular mRNA localisation at a glance
title_full Subcellular mRNA localisation at a glance
title_fullStr Subcellular mRNA localisation at a glance
title_full_unstemmed Subcellular mRNA localisation at a glance
title_short Subcellular mRNA localisation at a glance
title_sort subcellular mrna localisation at a glance
topic Cell Science at a Glance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021467/
https://www.ncbi.nlm.nih.gov/pubmed/24833669
http://dx.doi.org/10.1242/jcs.114272
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