Cargando…

Kinetics of mycolactone in human subcutaneous tissue during antibiotic therapy for Mycobacterium ulcerans disease

BACKGROUND: Mycobacterium ulcerans (M. ulcerans) causes a devastating necrotising infection of skin tissue leading to progressive ulceration. M. ulcerans is the only human pathogen that secretes mycolactone, a polyketide molecule with potent cytotoxic and immunomodulatory properties. These unique fe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sarfo, Fred S, Phillips, Richard O, Zhang, Jihui, Abass, Mohammed K, Abotsi, Justice, Amoako, Yaw A, Adu-Sarkodie, Yaw, Robinson, Clive, Wansbrough-Jones, Mark H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021496/ https://www.ncbi.nlm.nih.gov/pubmed/24731247 http://dx.doi.org/10.1186/1471-2334-14-202

Ejemplares similares

Recent advances: role of mycolactone in the pathogenesis and monitoring of Mycobacterium ulcerans infection/Buruli ulcer disease
por: Sarfo, Fred Stephen, et al.
Publicado: (2015)

Detection of Mycolactone A/B in Mycobacterium ulcerans–Infected Human Tissue
por: Sarfo, Fred Stephen, et al.
Publicado: (2010)

IFN-γ and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients with Mycobacterium ulcerans infection
por: Loglo, Aloysius D., et al.
Publicado: (2018)

Microbiological, Histological, Immunological, and Toxin Response to Antibiotic Treatment in the Mouse Model of Mycobacterium ulcerans Disease
por: Sarfo, Fred Stephen, et al.
Publicado: (2013)

Mycobacterium ulcerans mycolactones-fungi crosstalking
por: Hammoudi, Nassim, et al.
Publicado: (2019)

Mycolactone Diffuses into the Peripheral Blood of Buruli Ulcer Patients - Implications for Diagnosis and Disease Monitoring
por: Sarfo, Fred S., et al.
Publicado: (2011)

Simple, Rapid Mycobacterium ulcerans Disease Diagnosis from Clinical Samples by Fluorescence of Mycolactone on Thin Layer Chromatography
por: Wadagni, Anita, et al.
Publicado: (2015)

Photodegradation of the Mycobacterium ulcerans Toxin, Mycolactones: Considerations for Handling and Storage
por: Marion, Estelle, et al.
Publicado: (2012)

Regulation of Mycolactone, the Mycobacterium ulcerans Toxin, Depends on Nutrient Source
por: Deshayes, Caroline, et al.
Publicado: (2013)

Membrane perturbing properties of toxin mycolactone from Mycobacterium ulcerans
por: López, Cesar A., et al.
Publicado: (2018)

Selective suppression of dendritic cell functions by Mycobacterium ulcerans toxin mycolactone
por: Coutanceau, Emmanuelle, et al.
Publicado: (2007)

Structure-Activity Relationship Studies on the Macrolide Exotoxin Mycolactone of Mycobacterium ulcerans
por: Scherr, Nicole, et al.
Publicado: (2013)

Development of an ELISA for the quantification of mycolactone, the cytotoxic macrolide toxin of Mycobacterium ulcerans
por: Warryn, Louisa, et al.
Publicado: (2020)

Induced Synthesis of Mycolactone Restores the Pathogenesis of Mycobacterium ulcerans In Vitro and In Vivo
por: Strong, Emily, et al.
Publicado: (2022)

Providing insight into the incubation period of Mycobacterium ulcerans disease: two case reports
por: Amoako, Y. A., et al.
Publicado: (2019)

Metabolomic profiles delineate mycolactone signature in Buruli ulcer disease
por: Niang, Fatoumata, et al.
Publicado: (2015)

Environmental Variations in Mycobacterium ulcerans Transcriptome: Absence of Mycolactone Expression in Suboptimal Environments
por: Sanhueza, Daniel, et al.
Publicado: (2019)

Molecular Mechanisms Underpinning the Circulation and Cellular Uptake of Mycobacterium ulcerans Toxin Mycolactone
por: Tello Rubio, Bruno, et al.
Publicado: (2021)

Mycobacterium ulcerans and Other Mycolactone-Producing Mycobacteria Should Be Considered a Single Species
por: Pidot, Sacha J., et al.
Publicado: (2010)

Antibody-Mediated Neutralization of the Exotoxin Mycolactone, the Main Virulence Factor Produced by Mycobacterium ulcerans
por: Dangy, Jean-Pierre, et al.
Publicado: (2016)

Transcriptional adaptation of Mycobacterium ulcerans in an original mouse model: New insights into the regulation of mycolactone
por: Robbe-Saule, Marie, et al.
Publicado: (2021)

Responses to chemical cross-talk between the Mycobacterium ulcerans toxin, mycolactone, and Staphylococcus aureus
por: Dhungel, Laxmi, et al.
Publicado: (2021)

Genetic Diversity of PCR-Positive, Culture-Negative and Culture-Positive Mycobacterium ulcerans Isolated from Buruli Ulcer Patients in Ghana
por: Williamson, Heather, et al.
Publicado: (2014)

Accelerated Detection of Mycolactone Production and Response to Antibiotic Treatment in a Mouse Model of Mycobacterium ulcerans Disease
por: Converse, Paul J., et al.
Publicado: (2014)

The Pathogenic Mechanism of the Mycobacterium ulcerans Virulence Factor, Mycolactone, Depends on Blockade of Protein Translocation into the ER
por: Hall, Belinda S., et al.
Publicado: (2014)

Proteomic Analysis of the Action of the Mycobacterium ulcerans Toxin Mycolactone: Targeting Host Cells Cytoskeleton and Collagen
por: Gama, José B., et al.
Publicado: (2014)

Skin-specific antibodies neutralizing mycolactone toxin during the spontaneous healing of Mycobacterium ulcerans infection
por: Foulon, Mélanie, et al.
Publicado: (2020)

Infection with Mansonella perstans Nematodes in Buruli Ulcer Patients, Ghana
por: Phillips, Richard O., et al.
Publicado: (2014)

Antioxidants Protect Keratinocytes against M. ulcerans Mycolactone Cytotoxicity
por: Grönberg, Alvar, et al.
Publicado: (2010)

A Severe Case of Buruli Ulcer Disease with Pleural Effusions
por: Sarfo, Fred S., et al.
Publicado: (2014)

Clearance of viable Mycobacterium ulcerans from Buruli ulcer lesions during antibiotic treatment as determined by combined 16S rRNA reverse transcriptase /IS 2404 qPCR assay
por: Sarpong-Duah, Mabel, et al.
Publicado: (2017)

Mycolactone Diffuses from Mycobacterium ulcerans–Infected Tissues and Targets Mononuclear Cells in Peripheral Blood and Lymphoid Organs
por: Hong, Hui, et al.
Publicado: (2008)

Behavioral interplay between mosquito and mycolactone produced by Mycobacterium ulcerans and bacterial gene expression induced by mosquito proximity
por: Kim, Dongmin, et al.
Publicado: (2023)

Detection of Viable Mycobacterium ulcerans in Clinical Samples by a Novel Combined 16S rRNA Reverse Transcriptase/IS2404 Real-Time qPCR Assay
por: Beissner, Marcus, et al.
Publicado: (2012)

Cellular Immunity Confers Transient Protection in Experimental Buruli Ulcer following BCG or Mycolactone-Negative Mycobacterium ulcerans Vaccination
por: Fraga, Alexandra G., et al.
Publicado: (2012)

Mycolactone Gene Expression Is Controlled by Strong SigA-Like Promoters with Utility in Studies of Mycobacterium ulcerans and Buruli Ulcer
por: Tobias, Nicholas J., et al.
Publicado: (2009)

Analysis of the Vaccine Potential of Plasmid DNA Encoding Nine Mycolactone Polyketide Synthase Domains in Mycobacterium ulcerans Infected Mice
por: Roupie, Virginie, et al.
Publicado: (2014)

Mycolactone as Analgesic: Subcutaneous Bioavailability Parameters
por: Babonneau, Jérémie, et al.
Publicado: (2019)

Rapid detection of Mycobacterium ulcerans with isothermal recombinase polymerase amplification assay
por: Frimpong, Michael, et al.
Publicado: (2019)

Correction: Mycolactone Gene Expression Is Controlled by Strong SigA-Like Promoters with Utility in Studies of Mycobacterium ulcerans and Buruli Ulcer
por: Tobias, Nicholas J., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_hcf3npm3i318qg8njqfvqel568