SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1

BACKGROUND: Grb2 (Growth factor receptor-bound protein 2) is a key adaptor protein in maintaining the ERK activity via linking Sos1 (Son of sevenless homolog 1) or other proteins to activated RTKs, such as EGFR. Currently, little knowledge is available concerning the post-translational modification...

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Detalles Bibliográficos
Autores principales: Qu, Yingying, Chen, Qin, Lai, Xueping, Zhu, Changhong, Chen, Cheng, Zhao, Xian, Deng, Rong, Xu, Ming, Yuan, Haihua, Wang, Yanli, Yu, Jianxiu, Huang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021559/
https://www.ncbi.nlm.nih.gov/pubmed/24775912
http://dx.doi.org/10.1186/1476-4598-13-95

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