Interferon-induced HERC5 is evolving under positive selection and inhibits HIV-1 particle production by a novel mechanism targeting Rev/RRE-dependent RNA nuclear export

BACKGROUND: Type I interferon (IFN) inhibits virus replication by activating multiple antiviral mechanisms and pathways. It has long been recognized that type I IFNs can potently block HIV-1 replication in vitro; as such, HIV-1 has been used as a system to identify and characterize IFN-induced antiv...

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Detalles Bibliográficos
Autores principales: Woods, Matthew William, Tong, Jessica Gayle, Tom, Sean Kevin, Szabo, Peter Anthony, Cavanagh, Peter Craig, Dikeakos, Jimmy Dimitrios, Haeryfar, SM Mansour, Barr, Stephen Dominic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021598/
https://www.ncbi.nlm.nih.gov/pubmed/24693865
http://dx.doi.org/10.1186/1742-4690-11-27

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