Chronic brain inflammation causes a reduction in GluN2A and GluN2B subunits of NMDA receptors and an increase in the phosphorylation of mitogen-activated protein kinases in the hippocampus

Neuroinflammation plays a key role in the initiation and progression of neurodegeneration in Alzheimer’s disease (AD). Chronic neuroinflammation results in diminished synaptic plasticity and loss of GluN1 N-methyl-D-aspartate (NMDA) receptors in the hippocampus, leading to the cognitive deficits tha...

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Detalles Bibliográficos
Autores principales: Ma, Jinhua, Choi, Bo-Ryoung, Chung, ChiHye, Min, Sun Seek, Jeon, Won Kyung, Han, Jung-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021635/
https://www.ncbi.nlm.nih.gov/pubmed/24761931
http://dx.doi.org/10.1186/1756-6606-7-33

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