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Extended-spectrum beta-lactamase-positive Escherichia coli causing complicated upper urinary tract infection: Urologist should act in time

OBJECTIVE: Recently, many articles reported increased incidence of urinary tract infection (UTI) due to Extended-Spectrum Beta-Lactamase (ESBL)-producing E. coli. No data are available to date regarding patients presenting with complicated upper ESBL-positive E. coli UTI and sepsis. We report the cl...

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Autores principales: Picozzi, Stefano C. M., Casellato, Stefano, Rossini, Mattia, Paola, Gaia, Tejada, Milvana, Costa, Elena, Carmignani, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021646/
https://www.ncbi.nlm.nih.gov/pubmed/24833818
http://dx.doi.org/10.4103/0974-7796.130536
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author Picozzi, Stefano C. M.
Casellato, Stefano
Rossini, Mattia
Paola, Gaia
Tejada, Milvana
Costa, Elena
Carmignani, Luca
author_facet Picozzi, Stefano C. M.
Casellato, Stefano
Rossini, Mattia
Paola, Gaia
Tejada, Milvana
Costa, Elena
Carmignani, Luca
author_sort Picozzi, Stefano C. M.
collection PubMed
description OBJECTIVE: Recently, many articles reported increased incidence of urinary tract infection (UTI) due to Extended-Spectrum Beta-Lactamase (ESBL)-producing E. coli. No data are available to date regarding patients presenting with complicated upper ESBL-positive E. coli UTI and sepsis. We report the clinical presentation, management, and outcomes in seven cases. MATERIALS AND METHODS: This prospective study was carried out between January 2008 and September 2011. Follow-ups varied in patients according to their disease presentation and clinical outcomes. All strains were cultured and identified by the Clinical Microbiology Laboratory and were recovered from blood and urine cultures. In-vitro presence of ESBL was confirmed with Clinical and Laboratory Standard Institute double disc method. RESULTS: In the study period, 49 patients needed hospitalization for upper UTI. Overall, in 25 patients (51%), cultures were negative. In the remaining, seven patients (14.3%) presented positive blood and urine-culture for ESBL + E. coli. Of these, four were female and three were male. Their median age was 73 years (range 66-84). The median hospital stay of these patients was 23 days (range 13 to 45 days). CONCLUSIONS: The current situation of multiple bacterial antibiotic resistance has become a worrisome issue in UTI. Multi-drug-resistant E. coli can be readily encountered in hospital settings during daily clinical practice, and urologist should act timely. The management of such infections is extremely important for the future, with particular reference to prevention of new antibiotic resistance patterns.
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spelling pubmed-40216462014-05-15 Extended-spectrum beta-lactamase-positive Escherichia coli causing complicated upper urinary tract infection: Urologist should act in time Picozzi, Stefano C. M. Casellato, Stefano Rossini, Mattia Paola, Gaia Tejada, Milvana Costa, Elena Carmignani, Luca Urol Ann Original Article OBJECTIVE: Recently, many articles reported increased incidence of urinary tract infection (UTI) due to Extended-Spectrum Beta-Lactamase (ESBL)-producing E. coli. No data are available to date regarding patients presenting with complicated upper ESBL-positive E. coli UTI and sepsis. We report the clinical presentation, management, and outcomes in seven cases. MATERIALS AND METHODS: This prospective study was carried out between January 2008 and September 2011. Follow-ups varied in patients according to their disease presentation and clinical outcomes. All strains were cultured and identified by the Clinical Microbiology Laboratory and were recovered from blood and urine cultures. In-vitro presence of ESBL was confirmed with Clinical and Laboratory Standard Institute double disc method. RESULTS: In the study period, 49 patients needed hospitalization for upper UTI. Overall, in 25 patients (51%), cultures were negative. In the remaining, seven patients (14.3%) presented positive blood and urine-culture for ESBL + E. coli. Of these, four were female and three were male. Their median age was 73 years (range 66-84). The median hospital stay of these patients was 23 days (range 13 to 45 days). CONCLUSIONS: The current situation of multiple bacterial antibiotic resistance has become a worrisome issue in UTI. Multi-drug-resistant E. coli can be readily encountered in hospital settings during daily clinical practice, and urologist should act timely. The management of such infections is extremely important for the future, with particular reference to prevention of new antibiotic resistance patterns. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4021646/ /pubmed/24833818 http://dx.doi.org/10.4103/0974-7796.130536 Text en Copyright: © Urology Annals http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Picozzi, Stefano C. M.
Casellato, Stefano
Rossini, Mattia
Paola, Gaia
Tejada, Milvana
Costa, Elena
Carmignani, Luca
Extended-spectrum beta-lactamase-positive Escherichia coli causing complicated upper urinary tract infection: Urologist should act in time
title Extended-spectrum beta-lactamase-positive Escherichia coli causing complicated upper urinary tract infection: Urologist should act in time
title_full Extended-spectrum beta-lactamase-positive Escherichia coli causing complicated upper urinary tract infection: Urologist should act in time
title_fullStr Extended-spectrum beta-lactamase-positive Escherichia coli causing complicated upper urinary tract infection: Urologist should act in time
title_full_unstemmed Extended-spectrum beta-lactamase-positive Escherichia coli causing complicated upper urinary tract infection: Urologist should act in time
title_short Extended-spectrum beta-lactamase-positive Escherichia coli causing complicated upper urinary tract infection: Urologist should act in time
title_sort extended-spectrum beta-lactamase-positive escherichia coli causing complicated upper urinary tract infection: urologist should act in time
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021646/
https://www.ncbi.nlm.nih.gov/pubmed/24833818
http://dx.doi.org/10.4103/0974-7796.130536
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