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Bedside Tested Ocular Motor Disorders in Multiple Sclerosis Patients
Background/Aims. Ocular motor disorders (OMDs) are a common feature of multiple sclerosis (MS). In clinical practice, if not reported by patients, OMDs are often underdiagnosed and their prevalence is underestimated. Methods. We studied 163 patients (125 women, 76.7%, 38 men, 23.3%; median age 45.0...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021677/ https://www.ncbi.nlm.nih.gov/pubmed/24876966 http://dx.doi.org/10.1155/2014/732329 |
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author | Servillo, G. Renard, D. Taieb, G. Labauge, P. Bastide, S. Zorzon, M. Castelnovo, G. |
author_facet | Servillo, G. Renard, D. Taieb, G. Labauge, P. Bastide, S. Zorzon, M. Castelnovo, G. |
author_sort | Servillo, G. |
collection | PubMed |
description | Background/Aims. Ocular motor disorders (OMDs) are a common feature of multiple sclerosis (MS). In clinical practice, if not reported by patients, OMDs are often underdiagnosed and their prevalence is underestimated. Methods. We studied 163 patients (125 women, 76.7%, 38 men, 23.3%; median age 45.0 years; median disease duration 10 years; median EDSS 3.5) with definite MS (n = 150, 92%) or clinically isolated syndrome (n = 13, 8%) who underwent a thorough clinical examination of eye movements. Data on localization of previous relapses, MS subtype, and MRI findings were collected and analyzed. Results. Overall, 111/163 (68.1%) patients showed at least one abnormality of eye movement. Most frequent OMDs were impaired smooth pursuit (42.3%), saccadic dysmetria (41.7%), unilateral internuclear ophthalmoplegia (14.7%), slowing of saccades (14.7%), skew deviation (13.5%), and gaze evoked nystagmus (13.5%). Patients with OMDs had more severe disability (P = 0.0005) and showed more frequently infratentorial MRI lesions (P = 0.004). Localization of previous relapses was not associated with presence of OMDs. Conclusion. OMDs are frequent in patients with stable (no relapses) MS. A precise bedside examination of eye motility can disclose abnormalities that imply the presence of subclinical MS lesions and may have a substantial impact on definition of the diagnosis and on management of MS patients. |
format | Online Article Text |
id | pubmed-4021677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40216772014-05-29 Bedside Tested Ocular Motor Disorders in Multiple Sclerosis Patients Servillo, G. Renard, D. Taieb, G. Labauge, P. Bastide, S. Zorzon, M. Castelnovo, G. Mult Scler Int Research Article Background/Aims. Ocular motor disorders (OMDs) are a common feature of multiple sclerosis (MS). In clinical practice, if not reported by patients, OMDs are often underdiagnosed and their prevalence is underestimated. Methods. We studied 163 patients (125 women, 76.7%, 38 men, 23.3%; median age 45.0 years; median disease duration 10 years; median EDSS 3.5) with definite MS (n = 150, 92%) or clinically isolated syndrome (n = 13, 8%) who underwent a thorough clinical examination of eye movements. Data on localization of previous relapses, MS subtype, and MRI findings were collected and analyzed. Results. Overall, 111/163 (68.1%) patients showed at least one abnormality of eye movement. Most frequent OMDs were impaired smooth pursuit (42.3%), saccadic dysmetria (41.7%), unilateral internuclear ophthalmoplegia (14.7%), slowing of saccades (14.7%), skew deviation (13.5%), and gaze evoked nystagmus (13.5%). Patients with OMDs had more severe disability (P = 0.0005) and showed more frequently infratentorial MRI lesions (P = 0.004). Localization of previous relapses was not associated with presence of OMDs. Conclusion. OMDs are frequent in patients with stable (no relapses) MS. A precise bedside examination of eye motility can disclose abnormalities that imply the presence of subclinical MS lesions and may have a substantial impact on definition of the diagnosis and on management of MS patients. Hindawi Publishing Corporation 2014 2014-04-30 /pmc/articles/PMC4021677/ /pubmed/24876966 http://dx.doi.org/10.1155/2014/732329 Text en Copyright © 2014 G. Servillo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Servillo, G. Renard, D. Taieb, G. Labauge, P. Bastide, S. Zorzon, M. Castelnovo, G. Bedside Tested Ocular Motor Disorders in Multiple Sclerosis Patients |
title | Bedside Tested Ocular Motor Disorders in Multiple Sclerosis Patients |
title_full | Bedside Tested Ocular Motor Disorders in Multiple Sclerosis Patients |
title_fullStr | Bedside Tested Ocular Motor Disorders in Multiple Sclerosis Patients |
title_full_unstemmed | Bedside Tested Ocular Motor Disorders in Multiple Sclerosis Patients |
title_short | Bedside Tested Ocular Motor Disorders in Multiple Sclerosis Patients |
title_sort | bedside tested ocular motor disorders in multiple sclerosis patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021677/ https://www.ncbi.nlm.nih.gov/pubmed/24876966 http://dx.doi.org/10.1155/2014/732329 |
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