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Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer

Intestinal homeostasis is precisely regulated by a number of endogenous regulatory molecules but significantly influenced by dietary compounds. Malfunction of this system may result in chronic inflammation and cancer. Dietary essential n-3 polyunsaturated fatty acids (PUFAs) and short-chain fatty ac...

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Autores principales: Hofmanová, Jiřina, Straková, Nicol, Vaculová, Alena Hyršlová, Tylichová, Zuzana, Šafaříková, Barbora, Skender, Belma, Kozubík, Alois
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021685/
https://www.ncbi.nlm.nih.gov/pubmed/24876678
http://dx.doi.org/10.1155/2014/848632
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author Hofmanová, Jiřina
Straková, Nicol
Vaculová, Alena Hyršlová
Tylichová, Zuzana
Šafaříková, Barbora
Skender, Belma
Kozubík, Alois
author_facet Hofmanová, Jiřina
Straková, Nicol
Vaculová, Alena Hyršlová
Tylichová, Zuzana
Šafaříková, Barbora
Skender, Belma
Kozubík, Alois
author_sort Hofmanová, Jiřina
collection PubMed
description Intestinal homeostasis is precisely regulated by a number of endogenous regulatory molecules but significantly influenced by dietary compounds. Malfunction of this system may result in chronic inflammation and cancer. Dietary essential n-3 polyunsaturated fatty acids (PUFAs) and short-chain fatty acid butyrate produced from fibre display anti-inflammatory and anticancer activities. Both compounds were shown to modulate the production and activities of TNF family cytokines. Cytokines from the TNF family (TNF-α, TRAIL, and FasL) have potent inflammatory activities and can also regulate apoptosis, which plays an important role in cancer development. The results of our own research showed enhancement of apoptosis in colon cancer cells by a combination of either docosahexaenoic acid (DHA) or butyrate with TNF family cytokines, especially by promotion of the mitochondrial apoptotic pathway and modulation of NFκB activity. This review is focused mainly on the interaction of dietary PUFAs and butyrate with these cytokines during colon inflammation and cancer development. We summarised recent knowledge about the cellular and molecular mechanisms involved in such effects and outcomes for intestinal cell behaviour and pathologies. Finally, the possible application for the prevention and therapy of colon inflammation and cancer is also outlined.
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spelling pubmed-40216852014-05-29 Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer Hofmanová, Jiřina Straková, Nicol Vaculová, Alena Hyršlová Tylichová, Zuzana Šafaříková, Barbora Skender, Belma Kozubík, Alois Mediators Inflamm Review Article Intestinal homeostasis is precisely regulated by a number of endogenous regulatory molecules but significantly influenced by dietary compounds. Malfunction of this system may result in chronic inflammation and cancer. Dietary essential n-3 polyunsaturated fatty acids (PUFAs) and short-chain fatty acid butyrate produced from fibre display anti-inflammatory and anticancer activities. Both compounds were shown to modulate the production and activities of TNF family cytokines. Cytokines from the TNF family (TNF-α, TRAIL, and FasL) have potent inflammatory activities and can also regulate apoptosis, which plays an important role in cancer development. The results of our own research showed enhancement of apoptosis in colon cancer cells by a combination of either docosahexaenoic acid (DHA) or butyrate with TNF family cytokines, especially by promotion of the mitochondrial apoptotic pathway and modulation of NFκB activity. This review is focused mainly on the interaction of dietary PUFAs and butyrate with these cytokines during colon inflammation and cancer development. We summarised recent knowledge about the cellular and molecular mechanisms involved in such effects and outcomes for intestinal cell behaviour and pathologies. Finally, the possible application for the prevention and therapy of colon inflammation and cancer is also outlined. Hindawi Publishing Corporation 2014 2014-04-30 /pmc/articles/PMC4021685/ /pubmed/24876678 http://dx.doi.org/10.1155/2014/848632 Text en Copyright © 2014 Jiřina Hofmanová et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Hofmanová, Jiřina
Straková, Nicol
Vaculová, Alena Hyršlová
Tylichová, Zuzana
Šafaříková, Barbora
Skender, Belma
Kozubík, Alois
Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer
title Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer
title_full Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer
title_fullStr Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer
title_full_unstemmed Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer
title_short Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer
title_sort interaction of dietary fatty acids with tumour necrosis factor family cytokines during colon inflammation and cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021685/
https://www.ncbi.nlm.nih.gov/pubmed/24876678
http://dx.doi.org/10.1155/2014/848632
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