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Ginseng and Anticancer Drug Combination to Improve Cancer Chemotherapy: A Critical Review
Ginseng, a well-known herb, is often used in combination with anticancer drugs to enhance chemotherapy. Its wide usage as well as many documentations are often cited to support its clinical benefit of such combination therapy. However the literature based on objective evidence to make such recommend...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021740/ https://www.ncbi.nlm.nih.gov/pubmed/24876866 http://dx.doi.org/10.1155/2014/168940 |
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author | Chen, Shihong Wang, Zhijun Huang, Ying O'Barr, Stephen A. Wong, Rebecca A. Yeung, Steven Chow, Moses Sing Sum |
author_facet | Chen, Shihong Wang, Zhijun Huang, Ying O'Barr, Stephen A. Wong, Rebecca A. Yeung, Steven Chow, Moses Sing Sum |
author_sort | Chen, Shihong |
collection | PubMed |
description | Ginseng, a well-known herb, is often used in combination with anticancer drugs to enhance chemotherapy. Its wide usage as well as many documentations are often cited to support its clinical benefit of such combination therapy. However the literature based on objective evidence to make such recommendation is still lacking. The present review critically evaluated relevant studies reported in English and Chinese literature on such combination. Based on our review, we found good evidence from in vitro and in vivo animal studies showing enhanced antitumor effect when ginseng is used in combination with some anticancer drugs. However, there is insufficient clinical evidence of such benefit as very few clinical studies are available. Future research should focus on clinically relevant studies of such combination to validate the utility of ginseng in cancer. |
format | Online Article Text |
id | pubmed-4021740 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40217402014-05-29 Ginseng and Anticancer Drug Combination to Improve Cancer Chemotherapy: A Critical Review Chen, Shihong Wang, Zhijun Huang, Ying O'Barr, Stephen A. Wong, Rebecca A. Yeung, Steven Chow, Moses Sing Sum Evid Based Complement Alternat Med Review Article Ginseng, a well-known herb, is often used in combination with anticancer drugs to enhance chemotherapy. Its wide usage as well as many documentations are often cited to support its clinical benefit of such combination therapy. However the literature based on objective evidence to make such recommendation is still lacking. The present review critically evaluated relevant studies reported in English and Chinese literature on such combination. Based on our review, we found good evidence from in vitro and in vivo animal studies showing enhanced antitumor effect when ginseng is used in combination with some anticancer drugs. However, there is insufficient clinical evidence of such benefit as very few clinical studies are available. Future research should focus on clinically relevant studies of such combination to validate the utility of ginseng in cancer. Hindawi Publishing Corporation 2014 2014-04-30 /pmc/articles/PMC4021740/ /pubmed/24876866 http://dx.doi.org/10.1155/2014/168940 Text en Copyright © 2014 Shihong Chen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Chen, Shihong Wang, Zhijun Huang, Ying O'Barr, Stephen A. Wong, Rebecca A. Yeung, Steven Chow, Moses Sing Sum Ginseng and Anticancer Drug Combination to Improve Cancer Chemotherapy: A Critical Review |
title | Ginseng and Anticancer Drug Combination to Improve Cancer Chemotherapy: A Critical Review |
title_full | Ginseng and Anticancer Drug Combination to Improve Cancer Chemotherapy: A Critical Review |
title_fullStr | Ginseng and Anticancer Drug Combination to Improve Cancer Chemotherapy: A Critical Review |
title_full_unstemmed | Ginseng and Anticancer Drug Combination to Improve Cancer Chemotherapy: A Critical Review |
title_short | Ginseng and Anticancer Drug Combination to Improve Cancer Chemotherapy: A Critical Review |
title_sort | ginseng and anticancer drug combination to improve cancer chemotherapy: a critical review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021740/ https://www.ncbi.nlm.nih.gov/pubmed/24876866 http://dx.doi.org/10.1155/2014/168940 |
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