Cargando…

Evaluation on Potential Contributions of Protease Activated Receptors Related Mediators in Allergic Inflammation

Protease activated receptors (PARs) have been recognized as a distinctive four-member family of seven transmembrane G protein-coupled receptors (GPCRs) that can be cleaved by certain serine proteases. In recent years, there has been considerable interest in the role of PARs in allergic inflammation,...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Huiyun, Zeng, Xiaoning, He, Shaoheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021743/
https://www.ncbi.nlm.nih.gov/pubmed/24876677
http://dx.doi.org/10.1155/2014/829068
_version_ 1782316291735945216
author Zhang, Huiyun
Zeng, Xiaoning
He, Shaoheng
author_facet Zhang, Huiyun
Zeng, Xiaoning
He, Shaoheng
author_sort Zhang, Huiyun
collection PubMed
description Protease activated receptors (PARs) have been recognized as a distinctive four-member family of seven transmembrane G protein-coupled receptors (GPCRs) that can be cleaved by certain serine proteases. In recent years, there has been considerable interest in the role of PARs in allergic inflammation, the fundamental pathologic changes of allergy, but the potential roles of PARs in allergy remain obscure. Since many of these proteases are produced and actively involved in the pathologic process of inflammation including exudation of plasma components, inflammatory cell infiltration, and tissue damage and repair, PARs appear to make important contribution to allergy. The aim of the present review is to summarize the expression of PARs in inflammatory and structural cells, the influence of agonists or antagonists of PARs on cell behavior, and the involvement of PARs in allergic disorders, which will help us to better understand the roles of serine proteases and PARs in allergy.
format Online
Article
Text
id pubmed-4021743
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-40217432014-05-29 Evaluation on Potential Contributions of Protease Activated Receptors Related Mediators in Allergic Inflammation Zhang, Huiyun Zeng, Xiaoning He, Shaoheng Mediators Inflamm Review Article Protease activated receptors (PARs) have been recognized as a distinctive four-member family of seven transmembrane G protein-coupled receptors (GPCRs) that can be cleaved by certain serine proteases. In recent years, there has been considerable interest in the role of PARs in allergic inflammation, the fundamental pathologic changes of allergy, but the potential roles of PARs in allergy remain obscure. Since many of these proteases are produced and actively involved in the pathologic process of inflammation including exudation of plasma components, inflammatory cell infiltration, and tissue damage and repair, PARs appear to make important contribution to allergy. The aim of the present review is to summarize the expression of PARs in inflammatory and structural cells, the influence of agonists or antagonists of PARs on cell behavior, and the involvement of PARs in allergic disorders, which will help us to better understand the roles of serine proteases and PARs in allergy. Hindawi Publishing Corporation 2014 2014-04-30 /pmc/articles/PMC4021743/ /pubmed/24876677 http://dx.doi.org/10.1155/2014/829068 Text en Copyright © 2014 Huiyun Zhang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhang, Huiyun
Zeng, Xiaoning
He, Shaoheng
Evaluation on Potential Contributions of Protease Activated Receptors Related Mediators in Allergic Inflammation
title Evaluation on Potential Contributions of Protease Activated Receptors Related Mediators in Allergic Inflammation
title_full Evaluation on Potential Contributions of Protease Activated Receptors Related Mediators in Allergic Inflammation
title_fullStr Evaluation on Potential Contributions of Protease Activated Receptors Related Mediators in Allergic Inflammation
title_full_unstemmed Evaluation on Potential Contributions of Protease Activated Receptors Related Mediators in Allergic Inflammation
title_short Evaluation on Potential Contributions of Protease Activated Receptors Related Mediators in Allergic Inflammation
title_sort evaluation on potential contributions of protease activated receptors related mediators in allergic inflammation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021743/
https://www.ncbi.nlm.nih.gov/pubmed/24876677
http://dx.doi.org/10.1155/2014/829068
work_keys_str_mv AT zhanghuiyun evaluationonpotentialcontributionsofproteaseactivatedreceptorsrelatedmediatorsinallergicinflammation
AT zengxiaoning evaluationonpotentialcontributionsofproteaseactivatedreceptorsrelatedmediatorsinallergicinflammation
AT heshaoheng evaluationonpotentialcontributionsofproteaseactivatedreceptorsrelatedmediatorsinallergicinflammation