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Evaluation on Potential Contributions of Protease Activated Receptors Related Mediators in Allergic Inflammation
Protease activated receptors (PARs) have been recognized as a distinctive four-member family of seven transmembrane G protein-coupled receptors (GPCRs) that can be cleaved by certain serine proteases. In recent years, there has been considerable interest in the role of PARs in allergic inflammation,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021743/ https://www.ncbi.nlm.nih.gov/pubmed/24876677 http://dx.doi.org/10.1155/2014/829068 |
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author | Zhang, Huiyun Zeng, Xiaoning He, Shaoheng |
author_facet | Zhang, Huiyun Zeng, Xiaoning He, Shaoheng |
author_sort | Zhang, Huiyun |
collection | PubMed |
description | Protease activated receptors (PARs) have been recognized as a distinctive four-member family of seven transmembrane G protein-coupled receptors (GPCRs) that can be cleaved by certain serine proteases. In recent years, there has been considerable interest in the role of PARs in allergic inflammation, the fundamental pathologic changes of allergy, but the potential roles of PARs in allergy remain obscure. Since many of these proteases are produced and actively involved in the pathologic process of inflammation including exudation of plasma components, inflammatory cell infiltration, and tissue damage and repair, PARs appear to make important contribution to allergy. The aim of the present review is to summarize the expression of PARs in inflammatory and structural cells, the influence of agonists or antagonists of PARs on cell behavior, and the involvement of PARs in allergic disorders, which will help us to better understand the roles of serine proteases and PARs in allergy. |
format | Online Article Text |
id | pubmed-4021743 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40217432014-05-29 Evaluation on Potential Contributions of Protease Activated Receptors Related Mediators in Allergic Inflammation Zhang, Huiyun Zeng, Xiaoning He, Shaoheng Mediators Inflamm Review Article Protease activated receptors (PARs) have been recognized as a distinctive four-member family of seven transmembrane G protein-coupled receptors (GPCRs) that can be cleaved by certain serine proteases. In recent years, there has been considerable interest in the role of PARs in allergic inflammation, the fundamental pathologic changes of allergy, but the potential roles of PARs in allergy remain obscure. Since many of these proteases are produced and actively involved in the pathologic process of inflammation including exudation of plasma components, inflammatory cell infiltration, and tissue damage and repair, PARs appear to make important contribution to allergy. The aim of the present review is to summarize the expression of PARs in inflammatory and structural cells, the influence of agonists or antagonists of PARs on cell behavior, and the involvement of PARs in allergic disorders, which will help us to better understand the roles of serine proteases and PARs in allergy. Hindawi Publishing Corporation 2014 2014-04-30 /pmc/articles/PMC4021743/ /pubmed/24876677 http://dx.doi.org/10.1155/2014/829068 Text en Copyright © 2014 Huiyun Zhang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhang, Huiyun Zeng, Xiaoning He, Shaoheng Evaluation on Potential Contributions of Protease Activated Receptors Related Mediators in Allergic Inflammation |
title | Evaluation on Potential Contributions of Protease Activated Receptors Related Mediators in Allergic Inflammation |
title_full | Evaluation on Potential Contributions of Protease Activated Receptors Related Mediators in Allergic Inflammation |
title_fullStr | Evaluation on Potential Contributions of Protease Activated Receptors Related Mediators in Allergic Inflammation |
title_full_unstemmed | Evaluation on Potential Contributions of Protease Activated Receptors Related Mediators in Allergic Inflammation |
title_short | Evaluation on Potential Contributions of Protease Activated Receptors Related Mediators in Allergic Inflammation |
title_sort | evaluation on potential contributions of protease activated receptors related mediators in allergic inflammation |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021743/ https://www.ncbi.nlm.nih.gov/pubmed/24876677 http://dx.doi.org/10.1155/2014/829068 |
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