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Inflammatory Response in Islet Transplantation

Islet cell transplantation is a promising beta cell replacement therapy for patients with brittle type 1 diabetes as well as refractory chronic pancreatitis. Despite the vast advancements made in this field, challenges still remain in achieving high frequency and long-term successful transplant outc...

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Autores principales: Kanak, Mazhar A., Takita, Morihito, Kunnathodi, Faisal, Lawrence, Michael C., Levy, Marlon F., Naziruddin, Bashoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021753/
https://www.ncbi.nlm.nih.gov/pubmed/24883060
http://dx.doi.org/10.1155/2014/451035
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author Kanak, Mazhar A.
Takita, Morihito
Kunnathodi, Faisal
Lawrence, Michael C.
Levy, Marlon F.
Naziruddin, Bashoo
author_facet Kanak, Mazhar A.
Takita, Morihito
Kunnathodi, Faisal
Lawrence, Michael C.
Levy, Marlon F.
Naziruddin, Bashoo
author_sort Kanak, Mazhar A.
collection PubMed
description Islet cell transplantation is a promising beta cell replacement therapy for patients with brittle type 1 diabetes as well as refractory chronic pancreatitis. Despite the vast advancements made in this field, challenges still remain in achieving high frequency and long-term successful transplant outcomes. Here we review recent advances in understanding the role of inflammation in islet transplantation and development of strategies to prevent damage to islets from inflammation. The inflammatory response associated with islets has been recognized as the primary cause of early damage to islets and graft loss after transplantation. Details on cell signaling pathways in islets triggered by cytokines and harmful inflammatory events during pancreas procurement, pancreas preservation, islet isolation, and islet infusion are presented. Robust control of pre- and peritransplant islet inflammation could improve posttransplant islet survival and in turn enhance the benefits of islet cell transplantation for patients who are insulin dependent. We discuss several potent anti-inflammatory strategies that show promise for improving islet engraftment. Further understanding of molecular mechanisms involved in the inflammatory response will provide the basis for developing potent therapeutic strategies for enhancing the quality and success of islet transplantation.
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spelling pubmed-40217532014-06-01 Inflammatory Response in Islet Transplantation Kanak, Mazhar A. Takita, Morihito Kunnathodi, Faisal Lawrence, Michael C. Levy, Marlon F. Naziruddin, Bashoo Int J Endocrinol Review Article Islet cell transplantation is a promising beta cell replacement therapy for patients with brittle type 1 diabetes as well as refractory chronic pancreatitis. Despite the vast advancements made in this field, challenges still remain in achieving high frequency and long-term successful transplant outcomes. Here we review recent advances in understanding the role of inflammation in islet transplantation and development of strategies to prevent damage to islets from inflammation. The inflammatory response associated with islets has been recognized as the primary cause of early damage to islets and graft loss after transplantation. Details on cell signaling pathways in islets triggered by cytokines and harmful inflammatory events during pancreas procurement, pancreas preservation, islet isolation, and islet infusion are presented. Robust control of pre- and peritransplant islet inflammation could improve posttransplant islet survival and in turn enhance the benefits of islet cell transplantation for patients who are insulin dependent. We discuss several potent anti-inflammatory strategies that show promise for improving islet engraftment. Further understanding of molecular mechanisms involved in the inflammatory response will provide the basis for developing potent therapeutic strategies for enhancing the quality and success of islet transplantation. Hindawi Publishing Corporation 2014 2014-04-30 /pmc/articles/PMC4021753/ /pubmed/24883060 http://dx.doi.org/10.1155/2014/451035 Text en Copyright © 2014 Mazhar A. Kanak et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kanak, Mazhar A.
Takita, Morihito
Kunnathodi, Faisal
Lawrence, Michael C.
Levy, Marlon F.
Naziruddin, Bashoo
Inflammatory Response in Islet Transplantation
title Inflammatory Response in Islet Transplantation
title_full Inflammatory Response in Islet Transplantation
title_fullStr Inflammatory Response in Islet Transplantation
title_full_unstemmed Inflammatory Response in Islet Transplantation
title_short Inflammatory Response in Islet Transplantation
title_sort inflammatory response in islet transplantation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021753/
https://www.ncbi.nlm.nih.gov/pubmed/24883060
http://dx.doi.org/10.1155/2014/451035
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AT naziruddinbashoo inflammatoryresponseinislettransplantation