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Anticancer activity of cationic porphyrins in melanoma tumour-bearing mice and mechanistic in vitro studies
BACKGROUND: Porphyrin TMPyP4 (P4) and its C(14)H(28)-alkyl derivative (C14) are G-quadruplex binders and singlet oxygen ((1)O(2)) generators. In contrast, TMPyP2 (P2) produces (1)O(2) but it is not a G-quadruplex binder. As their photosensitizing activity is currently undefined, we report in this st...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021972/ https://www.ncbi.nlm.nih.gov/pubmed/24684778 http://dx.doi.org/10.1186/1476-4598-13-75 |