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Mannan-Binding Lectin in Cardiovascular Disease
Cardiovascular disease remains the leading cause of mortality and morbidity worldwide so research continues into underlying mechanisms. Since innate immunity and its potent component mannan-binding lectin have been proven to play an important role in the inflammatory response during infection and is...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022110/ https://www.ncbi.nlm.nih.gov/pubmed/24877121 http://dx.doi.org/10.1155/2014/616817 |
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author | Pągowska-Klimek, Izabela Cedzyński, Maciej |
author_facet | Pągowska-Klimek, Izabela Cedzyński, Maciej |
author_sort | Pągowska-Klimek, Izabela |
collection | PubMed |
description | Cardiovascular disease remains the leading cause of mortality and morbidity worldwide so research continues into underlying mechanisms. Since innate immunity and its potent component mannan-binding lectin have been proven to play an important role in the inflammatory response during infection and ischaemia-reperfusion injury, attention has been paid to its role in the development of cardiovascular complications as well. This review provides a general outline of the structure and genetic polymorphism of MBL and its role in inflammation/tissue injury with emphasis on associations with cardiovascular disease. MBL appears to be involved in the pathogenesis of atherosclerosis and, in consequence, coronary artery disease and also inflammation and tissue injury after myocardial infarction and heart transplantation. The relationship between MBL and disease is rather complex and depends on different genetic and environmental factors. That could be why the data obtained from animal and clinical studies are sometimes contradictory proving not for the first time that innate immunity is a “double-edge sword,” sometimes beneficial and, at other times disastrous for the host. |
format | Online Article Text |
id | pubmed-4022110 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40221102014-05-29 Mannan-Binding Lectin in Cardiovascular Disease Pągowska-Klimek, Izabela Cedzyński, Maciej Biomed Res Int Review Article Cardiovascular disease remains the leading cause of mortality and morbidity worldwide so research continues into underlying mechanisms. Since innate immunity and its potent component mannan-binding lectin have been proven to play an important role in the inflammatory response during infection and ischaemia-reperfusion injury, attention has been paid to its role in the development of cardiovascular complications as well. This review provides a general outline of the structure and genetic polymorphism of MBL and its role in inflammation/tissue injury with emphasis on associations with cardiovascular disease. MBL appears to be involved in the pathogenesis of atherosclerosis and, in consequence, coronary artery disease and also inflammation and tissue injury after myocardial infarction and heart transplantation. The relationship between MBL and disease is rather complex and depends on different genetic and environmental factors. That could be why the data obtained from animal and clinical studies are sometimes contradictory proving not for the first time that innate immunity is a “double-edge sword,” sometimes beneficial and, at other times disastrous for the host. Hindawi Publishing Corporation 2014 2014-04-30 /pmc/articles/PMC4022110/ /pubmed/24877121 http://dx.doi.org/10.1155/2014/616817 Text en Copyright © 2014 I. Pągowska-Klimek and M. Cedzyński. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Pągowska-Klimek, Izabela Cedzyński, Maciej Mannan-Binding Lectin in Cardiovascular Disease |
title | Mannan-Binding Lectin in Cardiovascular Disease |
title_full | Mannan-Binding Lectin in Cardiovascular Disease |
title_fullStr | Mannan-Binding Lectin in Cardiovascular Disease |
title_full_unstemmed | Mannan-Binding Lectin in Cardiovascular Disease |
title_short | Mannan-Binding Lectin in Cardiovascular Disease |
title_sort | mannan-binding lectin in cardiovascular disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022110/ https://www.ncbi.nlm.nih.gov/pubmed/24877121 http://dx.doi.org/10.1155/2014/616817 |
work_keys_str_mv | AT pagowskaklimekizabela mannanbindinglectinincardiovasculardisease AT cedzynskimaciej mannanbindinglectinincardiovasculardisease |