Cargando…

Mannan-Binding Lectin in Cardiovascular Disease

Cardiovascular disease remains the leading cause of mortality and morbidity worldwide so research continues into underlying mechanisms. Since innate immunity and its potent component mannan-binding lectin have been proven to play an important role in the inflammatory response during infection and is...

Descripción completa

Detalles Bibliográficos
Autores principales: Pągowska-Klimek, Izabela, Cedzyński, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022110/
https://www.ncbi.nlm.nih.gov/pubmed/24877121
http://dx.doi.org/10.1155/2014/616817
_version_ 1782316349749460992
author Pągowska-Klimek, Izabela
Cedzyński, Maciej
author_facet Pągowska-Klimek, Izabela
Cedzyński, Maciej
author_sort Pągowska-Klimek, Izabela
collection PubMed
description Cardiovascular disease remains the leading cause of mortality and morbidity worldwide so research continues into underlying mechanisms. Since innate immunity and its potent component mannan-binding lectin have been proven to play an important role in the inflammatory response during infection and ischaemia-reperfusion injury, attention has been paid to its role in the development of cardiovascular complications as well. This review provides a general outline of the structure and genetic polymorphism of MBL and its role in inflammation/tissue injury with emphasis on associations with cardiovascular disease. MBL appears to be involved in the pathogenesis of atherosclerosis and, in consequence, coronary artery disease and also inflammation and tissue injury after myocardial infarction and heart transplantation. The relationship between MBL and disease is rather complex and depends on different genetic and environmental factors. That could be why the data obtained from animal and clinical studies are sometimes contradictory proving not for the first time that innate immunity is a “double-edge sword,” sometimes beneficial and, at other times disastrous for the host.
format Online
Article
Text
id pubmed-4022110
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-40221102014-05-29 Mannan-Binding Lectin in Cardiovascular Disease Pągowska-Klimek, Izabela Cedzyński, Maciej Biomed Res Int Review Article Cardiovascular disease remains the leading cause of mortality and morbidity worldwide so research continues into underlying mechanisms. Since innate immunity and its potent component mannan-binding lectin have been proven to play an important role in the inflammatory response during infection and ischaemia-reperfusion injury, attention has been paid to its role in the development of cardiovascular complications as well. This review provides a general outline of the structure and genetic polymorphism of MBL and its role in inflammation/tissue injury with emphasis on associations with cardiovascular disease. MBL appears to be involved in the pathogenesis of atherosclerosis and, in consequence, coronary artery disease and also inflammation and tissue injury after myocardial infarction and heart transplantation. The relationship between MBL and disease is rather complex and depends on different genetic and environmental factors. That could be why the data obtained from animal and clinical studies are sometimes contradictory proving not for the first time that innate immunity is a “double-edge sword,” sometimes beneficial and, at other times disastrous for the host. Hindawi Publishing Corporation 2014 2014-04-30 /pmc/articles/PMC4022110/ /pubmed/24877121 http://dx.doi.org/10.1155/2014/616817 Text en Copyright © 2014 I. Pągowska-Klimek and M. Cedzyński. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Pągowska-Klimek, Izabela
Cedzyński, Maciej
Mannan-Binding Lectin in Cardiovascular Disease
title Mannan-Binding Lectin in Cardiovascular Disease
title_full Mannan-Binding Lectin in Cardiovascular Disease
title_fullStr Mannan-Binding Lectin in Cardiovascular Disease
title_full_unstemmed Mannan-Binding Lectin in Cardiovascular Disease
title_short Mannan-Binding Lectin in Cardiovascular Disease
title_sort mannan-binding lectin in cardiovascular disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022110/
https://www.ncbi.nlm.nih.gov/pubmed/24877121
http://dx.doi.org/10.1155/2014/616817
work_keys_str_mv AT pagowskaklimekizabela mannanbindinglectinincardiovasculardisease
AT cedzynskimaciej mannanbindinglectinincardiovasculardisease