Intrathecal antagonism of microglial TLR(4) reduces inflammatory damage to blood–spinal cord barrier following ischemia/reperfusion injury in rats

BACKGROUND: Inflammatory reaction in blood–spinal cord barrier (BSCB) plays a crucial role in ischemia/reperfusion (I/R) injury. It has been shown that microglia could be activated through Toll-like receptors (TLRs). Therefore, we hypothesize that TLR4 is involved in the microglial activation and BS...

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Detalles Bibliográficos
Autores principales: Li, Xiao-Qian, Wang, Jun, Fang, Bo, Tan, Wen-Fei, Ma, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022154/
https://www.ncbi.nlm.nih.gov/pubmed/24751148
http://dx.doi.org/10.1186/1756-6606-7-28

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