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Early Treatment Response Monitoring Using 2-Deoxy-2-[(18)F]fluoro-D-glucose Positron Emission Tomography Imaging during Fractionated Radiotherapy of Head Neck Cancer Xenografts

Background. To determine the optimal timing and analytic method of 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography (PET) imaging during fractionated radiotherapy (RT) to predict tumor control. Methods. Ten head neck squamous cell carcinoma xenografts derived from the UT-14-SCC cell li...

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Autores principales: Huang, Jiayi, Chunta, John L., Amin, Mitual, Lee, David Y., Grills, Inga S., Oliver Wong, Ching-Yee, Marples, Brian, Yan, Di, Wilson, George D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022256/
https://www.ncbi.nlm.nih.gov/pubmed/24877119
http://dx.doi.org/10.1155/2014/598052
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author Huang, Jiayi
Chunta, John L.
Amin, Mitual
Lee, David Y.
Grills, Inga S.
Oliver Wong, Ching-Yee
Marples, Brian
Yan, Di
Wilson, George D.
author_facet Huang, Jiayi
Chunta, John L.
Amin, Mitual
Lee, David Y.
Grills, Inga S.
Oliver Wong, Ching-Yee
Marples, Brian
Yan, Di
Wilson, George D.
author_sort Huang, Jiayi
collection PubMed
description Background. To determine the optimal timing and analytic method of 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography (PET) imaging during fractionated radiotherapy (RT) to predict tumor control. Methods. Ten head neck squamous cell carcinoma xenografts derived from the UT-14-SCC cell line were irradiated with 50 Gy at 2 Gy per day over 5 weeks. Dynamic PET scans were acquired over 70 minutes at baseline (week 0) and weekly for seven weeks. PET data were analyzed using standard uptake value (SUV), retention index (RI), sensitivity factor (SF), and kinetic index (Ki). Results. Four xenografts had local failure (LF) and 6 had local control. Eighty scans from week 0 to week 7 were analyzed. RI and SF after 10 Gy appeared to be the optimal predictors for LF. In contrast, SUV and Ki during RT were not significant predictors for LF. Conclusion. RI and SF of PET obtained after the first week of fractionated RT were the optimal methods and timing to predict tumor control.
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spelling pubmed-40222562014-05-29 Early Treatment Response Monitoring Using 2-Deoxy-2-[(18)F]fluoro-D-glucose Positron Emission Tomography Imaging during Fractionated Radiotherapy of Head Neck Cancer Xenografts Huang, Jiayi Chunta, John L. Amin, Mitual Lee, David Y. Grills, Inga S. Oliver Wong, Ching-Yee Marples, Brian Yan, Di Wilson, George D. Biomed Res Int Research Article Background. To determine the optimal timing and analytic method of 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography (PET) imaging during fractionated radiotherapy (RT) to predict tumor control. Methods. Ten head neck squamous cell carcinoma xenografts derived from the UT-14-SCC cell line were irradiated with 50 Gy at 2 Gy per day over 5 weeks. Dynamic PET scans were acquired over 70 minutes at baseline (week 0) and weekly for seven weeks. PET data were analyzed using standard uptake value (SUV), retention index (RI), sensitivity factor (SF), and kinetic index (Ki). Results. Four xenografts had local failure (LF) and 6 had local control. Eighty scans from week 0 to week 7 were analyzed. RI and SF after 10 Gy appeared to be the optimal predictors for LF. In contrast, SUV and Ki during RT were not significant predictors for LF. Conclusion. RI and SF of PET obtained after the first week of fractionated RT were the optimal methods and timing to predict tumor control. Hindawi Publishing Corporation 2014 2014-04-28 /pmc/articles/PMC4022256/ /pubmed/24877119 http://dx.doi.org/10.1155/2014/598052 Text en Copyright © 2014 Jiayi Huang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Huang, Jiayi
Chunta, John L.
Amin, Mitual
Lee, David Y.
Grills, Inga S.
Oliver Wong, Ching-Yee
Marples, Brian
Yan, Di
Wilson, George D.
Early Treatment Response Monitoring Using 2-Deoxy-2-[(18)F]fluoro-D-glucose Positron Emission Tomography Imaging during Fractionated Radiotherapy of Head Neck Cancer Xenografts
title Early Treatment Response Monitoring Using 2-Deoxy-2-[(18)F]fluoro-D-glucose Positron Emission Tomography Imaging during Fractionated Radiotherapy of Head Neck Cancer Xenografts
title_full Early Treatment Response Monitoring Using 2-Deoxy-2-[(18)F]fluoro-D-glucose Positron Emission Tomography Imaging during Fractionated Radiotherapy of Head Neck Cancer Xenografts
title_fullStr Early Treatment Response Monitoring Using 2-Deoxy-2-[(18)F]fluoro-D-glucose Positron Emission Tomography Imaging during Fractionated Radiotherapy of Head Neck Cancer Xenografts
title_full_unstemmed Early Treatment Response Monitoring Using 2-Deoxy-2-[(18)F]fluoro-D-glucose Positron Emission Tomography Imaging during Fractionated Radiotherapy of Head Neck Cancer Xenografts
title_short Early Treatment Response Monitoring Using 2-Deoxy-2-[(18)F]fluoro-D-glucose Positron Emission Tomography Imaging during Fractionated Radiotherapy of Head Neck Cancer Xenografts
title_sort early treatment response monitoring using 2-deoxy-2-[(18)f]fluoro-d-glucose positron emission tomography imaging during fractionated radiotherapy of head neck cancer xenografts
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022256/
https://www.ncbi.nlm.nih.gov/pubmed/24877119
http://dx.doi.org/10.1155/2014/598052
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