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Early Treatment Response Monitoring Using 2-Deoxy-2-[(18)F]fluoro-D-glucose Positron Emission Tomography Imaging during Fractionated Radiotherapy of Head Neck Cancer Xenografts
Background. To determine the optimal timing and analytic method of 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography (PET) imaging during fractionated radiotherapy (RT) to predict tumor control. Methods. Ten head neck squamous cell carcinoma xenografts derived from the UT-14-SCC cell li...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022256/ https://www.ncbi.nlm.nih.gov/pubmed/24877119 http://dx.doi.org/10.1155/2014/598052 |
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author | Huang, Jiayi Chunta, John L. Amin, Mitual Lee, David Y. Grills, Inga S. Oliver Wong, Ching-Yee Marples, Brian Yan, Di Wilson, George D. |
author_facet | Huang, Jiayi Chunta, John L. Amin, Mitual Lee, David Y. Grills, Inga S. Oliver Wong, Ching-Yee Marples, Brian Yan, Di Wilson, George D. |
author_sort | Huang, Jiayi |
collection | PubMed |
description | Background. To determine the optimal timing and analytic method of 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography (PET) imaging during fractionated radiotherapy (RT) to predict tumor control. Methods. Ten head neck squamous cell carcinoma xenografts derived from the UT-14-SCC cell line were irradiated with 50 Gy at 2 Gy per day over 5 weeks. Dynamic PET scans were acquired over 70 minutes at baseline (week 0) and weekly for seven weeks. PET data were analyzed using standard uptake value (SUV), retention index (RI), sensitivity factor (SF), and kinetic index (Ki). Results. Four xenografts had local failure (LF) and 6 had local control. Eighty scans from week 0 to week 7 were analyzed. RI and SF after 10 Gy appeared to be the optimal predictors for LF. In contrast, SUV and Ki during RT were not significant predictors for LF. Conclusion. RI and SF of PET obtained after the first week of fractionated RT were the optimal methods and timing to predict tumor control. |
format | Online Article Text |
id | pubmed-4022256 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40222562014-05-29 Early Treatment Response Monitoring Using 2-Deoxy-2-[(18)F]fluoro-D-glucose Positron Emission Tomography Imaging during Fractionated Radiotherapy of Head Neck Cancer Xenografts Huang, Jiayi Chunta, John L. Amin, Mitual Lee, David Y. Grills, Inga S. Oliver Wong, Ching-Yee Marples, Brian Yan, Di Wilson, George D. Biomed Res Int Research Article Background. To determine the optimal timing and analytic method of 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography (PET) imaging during fractionated radiotherapy (RT) to predict tumor control. Methods. Ten head neck squamous cell carcinoma xenografts derived from the UT-14-SCC cell line were irradiated with 50 Gy at 2 Gy per day over 5 weeks. Dynamic PET scans were acquired over 70 minutes at baseline (week 0) and weekly for seven weeks. PET data were analyzed using standard uptake value (SUV), retention index (RI), sensitivity factor (SF), and kinetic index (Ki). Results. Four xenografts had local failure (LF) and 6 had local control. Eighty scans from week 0 to week 7 were analyzed. RI and SF after 10 Gy appeared to be the optimal predictors for LF. In contrast, SUV and Ki during RT were not significant predictors for LF. Conclusion. RI and SF of PET obtained after the first week of fractionated RT were the optimal methods and timing to predict tumor control. Hindawi Publishing Corporation 2014 2014-04-28 /pmc/articles/PMC4022256/ /pubmed/24877119 http://dx.doi.org/10.1155/2014/598052 Text en Copyright © 2014 Jiayi Huang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Huang, Jiayi Chunta, John L. Amin, Mitual Lee, David Y. Grills, Inga S. Oliver Wong, Ching-Yee Marples, Brian Yan, Di Wilson, George D. Early Treatment Response Monitoring Using 2-Deoxy-2-[(18)F]fluoro-D-glucose Positron Emission Tomography Imaging during Fractionated Radiotherapy of Head Neck Cancer Xenografts |
title | Early Treatment Response Monitoring Using 2-Deoxy-2-[(18)F]fluoro-D-glucose Positron Emission Tomography Imaging during Fractionated Radiotherapy of Head Neck Cancer Xenografts |
title_full | Early Treatment Response Monitoring Using 2-Deoxy-2-[(18)F]fluoro-D-glucose Positron Emission Tomography Imaging during Fractionated Radiotherapy of Head Neck Cancer Xenografts |
title_fullStr | Early Treatment Response Monitoring Using 2-Deoxy-2-[(18)F]fluoro-D-glucose Positron Emission Tomography Imaging during Fractionated Radiotherapy of Head Neck Cancer Xenografts |
title_full_unstemmed | Early Treatment Response Monitoring Using 2-Deoxy-2-[(18)F]fluoro-D-glucose Positron Emission Tomography Imaging during Fractionated Radiotherapy of Head Neck Cancer Xenografts |
title_short | Early Treatment Response Monitoring Using 2-Deoxy-2-[(18)F]fluoro-D-glucose Positron Emission Tomography Imaging during Fractionated Radiotherapy of Head Neck Cancer Xenografts |
title_sort | early treatment response monitoring using 2-deoxy-2-[(18)f]fluoro-d-glucose positron emission tomography imaging during fractionated radiotherapy of head neck cancer xenografts |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022256/ https://www.ncbi.nlm.nih.gov/pubmed/24877119 http://dx.doi.org/10.1155/2014/598052 |
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