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Structurally-Constrained Relationships between Cognitive States in the Human Brain
The anatomical connectivity of the human brain supports diverse patterns of correlated neural activity that are thought to underlie cognitive function. In a manner sensitive to underlying structural brain architecture, we examine the extent to which such patterns of correlated activity systematicall...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022461/ https://www.ncbi.nlm.nih.gov/pubmed/24830758 http://dx.doi.org/10.1371/journal.pcbi.1003591 |
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author | Hermundstad, Ann M. Brown, Kevin S. Bassett, Danielle S. Aminoff, Elissa M. Frithsen, Amy Johnson, Arianne Tipper, Christine M. Miller, Michael B. Grafton, Scott T. Carlson, Jean M. |
author_facet | Hermundstad, Ann M. Brown, Kevin S. Bassett, Danielle S. Aminoff, Elissa M. Frithsen, Amy Johnson, Arianne Tipper, Christine M. Miller, Michael B. Grafton, Scott T. Carlson, Jean M. |
author_sort | Hermundstad, Ann M. |
collection | PubMed |
description | The anatomical connectivity of the human brain supports diverse patterns of correlated neural activity that are thought to underlie cognitive function. In a manner sensitive to underlying structural brain architecture, we examine the extent to which such patterns of correlated activity systematically vary across cognitive states. Anatomical white matter connectivity is compared with functional correlations in neural activity measured via blood oxygen level dependent (BOLD) signals. Functional connectivity is separately measured at rest, during an attention task, and during a memory task. We assess these structural and functional measures within previously-identified resting-state functional networks, denoted task-positive and task-negative networks, that have been independently shown to be strongly anticorrelated at rest but also involve regions of the brain that routinely increase and decrease in activity during task-driven processes. We find that the density of anatomical connections within and between task-positive and task-negative networks is differentially related to strong, task-dependent correlations in neural activity. The space mapped out by the observed structure-function relationships is used to define a quantitative measure of separation between resting, attention, and memory states. We find that the degree of separation between states is related to both general measures of behavioral performance and relative differences in task-specific measures of attention versus memory performance. These findings suggest that the observed separation between cognitive states reflects underlying organizational principles of human brain structure and function. |
format | Online Article Text |
id | pubmed-4022461 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-40224612014-05-21 Structurally-Constrained Relationships between Cognitive States in the Human Brain Hermundstad, Ann M. Brown, Kevin S. Bassett, Danielle S. Aminoff, Elissa M. Frithsen, Amy Johnson, Arianne Tipper, Christine M. Miller, Michael B. Grafton, Scott T. Carlson, Jean M. PLoS Comput Biol Research Article The anatomical connectivity of the human brain supports diverse patterns of correlated neural activity that are thought to underlie cognitive function. In a manner sensitive to underlying structural brain architecture, we examine the extent to which such patterns of correlated activity systematically vary across cognitive states. Anatomical white matter connectivity is compared with functional correlations in neural activity measured via blood oxygen level dependent (BOLD) signals. Functional connectivity is separately measured at rest, during an attention task, and during a memory task. We assess these structural and functional measures within previously-identified resting-state functional networks, denoted task-positive and task-negative networks, that have been independently shown to be strongly anticorrelated at rest but also involve regions of the brain that routinely increase and decrease in activity during task-driven processes. We find that the density of anatomical connections within and between task-positive and task-negative networks is differentially related to strong, task-dependent correlations in neural activity. The space mapped out by the observed structure-function relationships is used to define a quantitative measure of separation between resting, attention, and memory states. We find that the degree of separation between states is related to both general measures of behavioral performance and relative differences in task-specific measures of attention versus memory performance. These findings suggest that the observed separation between cognitive states reflects underlying organizational principles of human brain structure and function. Public Library of Science 2014-05-15 /pmc/articles/PMC4022461/ /pubmed/24830758 http://dx.doi.org/10.1371/journal.pcbi.1003591 Text en © 2014 Hermundstad et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Hermundstad, Ann M. Brown, Kevin S. Bassett, Danielle S. Aminoff, Elissa M. Frithsen, Amy Johnson, Arianne Tipper, Christine M. Miller, Michael B. Grafton, Scott T. Carlson, Jean M. Structurally-Constrained Relationships between Cognitive States in the Human Brain |
title | Structurally-Constrained Relationships between Cognitive States in the Human Brain |
title_full | Structurally-Constrained Relationships between Cognitive States in the Human Brain |
title_fullStr | Structurally-Constrained Relationships between Cognitive States in the Human Brain |
title_full_unstemmed | Structurally-Constrained Relationships between Cognitive States in the Human Brain |
title_short | Structurally-Constrained Relationships between Cognitive States in the Human Brain |
title_sort | structurally-constrained relationships between cognitive states in the human brain |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022461/ https://www.ncbi.nlm.nih.gov/pubmed/24830758 http://dx.doi.org/10.1371/journal.pcbi.1003591 |
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