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Entacapone Reduces Cortical Activation in Parkinson's Disease with Wearing-Off: A f-MRI Study

BACKGROUND AND PURPOSE: Wearing-off is one of the most frequent problems encountered by levodopa-treated patients. Entacapone, a peripheral inhibitor of catechol-O-methyltransferase (COMT), reduces this motor complication by prolonging the effect of levodopa. We sought to understand the impact of CO...

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Autores principales: Tambasco, Nicola, Muti, Marco, Chiarini, Pietro, Tarducci, Roberto, Caproni, Stefano, Castrioto, Anna, Nigro, Pasquale, Parnetti, Lucilla, Floridi, Pietro, Rossi, Aroldo, Calabresi, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022515/
https://www.ncbi.nlm.nih.gov/pubmed/24830331
http://dx.doi.org/10.1371/journal.pone.0096806
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author Tambasco, Nicola
Muti, Marco
Chiarini, Pietro
Tarducci, Roberto
Caproni, Stefano
Castrioto, Anna
Nigro, Pasquale
Parnetti, Lucilla
Floridi, Pietro
Rossi, Aroldo
Calabresi, Paolo
author_facet Tambasco, Nicola
Muti, Marco
Chiarini, Pietro
Tarducci, Roberto
Caproni, Stefano
Castrioto, Anna
Nigro, Pasquale
Parnetti, Lucilla
Floridi, Pietro
Rossi, Aroldo
Calabresi, Paolo
author_sort Tambasco, Nicola
collection PubMed
description BACKGROUND AND PURPOSE: Wearing-off is one of the most frequent problems encountered by levodopa-treated patients. Entacapone, a peripheral inhibitor of catechol-O-methyltransferase (COMT), reduces this motor complication by prolonging the effect of levodopa. We sought to understand the impact of COMT-inhibition on movement execution in PD patients with wearing-off by comparing functional magnetic resonance imaging (f-MRI) activation patterns prior to and during entacapone treatment. Our hypothesis was to determine whether changes in cortical activation are associated to COMT-inhibitor treatment. METHODS: Nine levodopa-treated non-demented PD patients with wearing-off were prospectively studied in two f-MRI session, prior to and during entacapone treatment. A group of control subjects were also studied for comparison. RESULTS: The patients significantly improved under COMT-inhibitor treatment based on home diaries. F-MRI results showed that at baseline the patients presented a bilateral activation of the primary motor, controlateral premotor cortex and supplementary motor area, as well as ipsilateral cerebellum. During treatment with entacapone, PD patients showed reductions in the activations of these cortical areas and a decreased activation in the ipsilateral cerebellum. CONCLUSIONS: Our preliminary findings indicate that f-MRI is able to detect cortical activation changes during long-term modulation of dopaminergic treatment in PD patients with wearing-off, and thus, this technique could be further investigated in advanced PD patients.
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spelling pubmed-40225152014-05-21 Entacapone Reduces Cortical Activation in Parkinson's Disease with Wearing-Off: A f-MRI Study Tambasco, Nicola Muti, Marco Chiarini, Pietro Tarducci, Roberto Caproni, Stefano Castrioto, Anna Nigro, Pasquale Parnetti, Lucilla Floridi, Pietro Rossi, Aroldo Calabresi, Paolo PLoS One Research Article BACKGROUND AND PURPOSE: Wearing-off is one of the most frequent problems encountered by levodopa-treated patients. Entacapone, a peripheral inhibitor of catechol-O-methyltransferase (COMT), reduces this motor complication by prolonging the effect of levodopa. We sought to understand the impact of COMT-inhibition on movement execution in PD patients with wearing-off by comparing functional magnetic resonance imaging (f-MRI) activation patterns prior to and during entacapone treatment. Our hypothesis was to determine whether changes in cortical activation are associated to COMT-inhibitor treatment. METHODS: Nine levodopa-treated non-demented PD patients with wearing-off were prospectively studied in two f-MRI session, prior to and during entacapone treatment. A group of control subjects were also studied for comparison. RESULTS: The patients significantly improved under COMT-inhibitor treatment based on home diaries. F-MRI results showed that at baseline the patients presented a bilateral activation of the primary motor, controlateral premotor cortex and supplementary motor area, as well as ipsilateral cerebellum. During treatment with entacapone, PD patients showed reductions in the activations of these cortical areas and a decreased activation in the ipsilateral cerebellum. CONCLUSIONS: Our preliminary findings indicate that f-MRI is able to detect cortical activation changes during long-term modulation of dopaminergic treatment in PD patients with wearing-off, and thus, this technique could be further investigated in advanced PD patients. Public Library of Science 2014-05-15 /pmc/articles/PMC4022515/ /pubmed/24830331 http://dx.doi.org/10.1371/journal.pone.0096806 Text en © 2014 Tambasco et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Tambasco, Nicola
Muti, Marco
Chiarini, Pietro
Tarducci, Roberto
Caproni, Stefano
Castrioto, Anna
Nigro, Pasquale
Parnetti, Lucilla
Floridi, Pietro
Rossi, Aroldo
Calabresi, Paolo
Entacapone Reduces Cortical Activation in Parkinson's Disease with Wearing-Off: A f-MRI Study
title Entacapone Reduces Cortical Activation in Parkinson's Disease with Wearing-Off: A f-MRI Study
title_full Entacapone Reduces Cortical Activation in Parkinson's Disease with Wearing-Off: A f-MRI Study
title_fullStr Entacapone Reduces Cortical Activation in Parkinson's Disease with Wearing-Off: A f-MRI Study
title_full_unstemmed Entacapone Reduces Cortical Activation in Parkinson's Disease with Wearing-Off: A f-MRI Study
title_short Entacapone Reduces Cortical Activation in Parkinson's Disease with Wearing-Off: A f-MRI Study
title_sort entacapone reduces cortical activation in parkinson's disease with wearing-off: a f-mri study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022515/
https://www.ncbi.nlm.nih.gov/pubmed/24830331
http://dx.doi.org/10.1371/journal.pone.0096806
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