Cargando…
Systematic review of melanoma incidence and prognosis in solid organ transplant recipients
Cutaneous melanoma carries the potential for substantial morbidity and mortality in the solid organ transplant population. We systematically reviewed the literature published from January 1995 to January 2012 to determine the overall relative risk and prognosis of melanoma in transplant recipients....
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022534/ https://www.ncbi.nlm.nih.gov/pubmed/24834346 http://dx.doi.org/10.1186/2047-1440-3-10 |
_version_ | 1782316427197284352 |
---|---|
author | Dahlke, Erin Murray, Christian Alexander Kitchen, Jessica Chan, An-Wen |
author_facet | Dahlke, Erin Murray, Christian Alexander Kitchen, Jessica Chan, An-Wen |
author_sort | Dahlke, Erin |
collection | PubMed |
description | Cutaneous melanoma carries the potential for substantial morbidity and mortality in the solid organ transplant population. We systematically reviewed the literature published from January 1995 to January 2012 to determine the overall relative risk and prognosis of melanoma in transplant recipients. Our search identified 7,512 citations. Twelve unique non-overlapping studies reported the population-based incidence of melanoma in an inception cohort of solid organ transplant recipients. Compared to the general population, there is a 2.4-fold (95% confidence interval, 2.0 to 2.9) increased incidence of melanoma after transplantation. No population-based outcome data were identified for melanoma arising post-transplant. Data from non-population based cohort studies suggest a worse prognosis for late-stage melanoma developing after transplantation compared with the general population. For patients with a history of pre-transplant melanoma, one population-based study reported a local recurrence rate of 11% (2/19) after transplantation, although staging and survival information was lacking. There is a need for population-based data on the prognosis of melanoma arising pre- and post-transplantation. Increased incidence and potentially worse melanoma outcomes in this high-risk population have implications for clinical care in terms of prevention, screening and reduction of immunosuppression after melanoma development post-transplant, as well as transplantation decisions in patients with a history of pre-transplant melanoma. |
format | Online Article Text |
id | pubmed-4022534 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40225342014-05-16 Systematic review of melanoma incidence and prognosis in solid organ transplant recipients Dahlke, Erin Murray, Christian Alexander Kitchen, Jessica Chan, An-Wen Transplant Res Review Cutaneous melanoma carries the potential for substantial morbidity and mortality in the solid organ transplant population. We systematically reviewed the literature published from January 1995 to January 2012 to determine the overall relative risk and prognosis of melanoma in transplant recipients. Our search identified 7,512 citations. Twelve unique non-overlapping studies reported the population-based incidence of melanoma in an inception cohort of solid organ transplant recipients. Compared to the general population, there is a 2.4-fold (95% confidence interval, 2.0 to 2.9) increased incidence of melanoma after transplantation. No population-based outcome data were identified for melanoma arising post-transplant. Data from non-population based cohort studies suggest a worse prognosis for late-stage melanoma developing after transplantation compared with the general population. For patients with a history of pre-transplant melanoma, one population-based study reported a local recurrence rate of 11% (2/19) after transplantation, although staging and survival information was lacking. There is a need for population-based data on the prognosis of melanoma arising pre- and post-transplantation. Increased incidence and potentially worse melanoma outcomes in this high-risk population have implications for clinical care in terms of prevention, screening and reduction of immunosuppression after melanoma development post-transplant, as well as transplantation decisions in patients with a history of pre-transplant melanoma. BioMed Central 2014-05-06 /pmc/articles/PMC4022534/ /pubmed/24834346 http://dx.doi.org/10.1186/2047-1440-3-10 Text en Copyright © 2014 Dahlke et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Dahlke, Erin Murray, Christian Alexander Kitchen, Jessica Chan, An-Wen Systematic review of melanoma incidence and prognosis in solid organ transplant recipients |
title | Systematic review of melanoma incidence and prognosis in solid organ transplant recipients |
title_full | Systematic review of melanoma incidence and prognosis in solid organ transplant recipients |
title_fullStr | Systematic review of melanoma incidence and prognosis in solid organ transplant recipients |
title_full_unstemmed | Systematic review of melanoma incidence and prognosis in solid organ transplant recipients |
title_short | Systematic review of melanoma incidence and prognosis in solid organ transplant recipients |
title_sort | systematic review of melanoma incidence and prognosis in solid organ transplant recipients |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022534/ https://www.ncbi.nlm.nih.gov/pubmed/24834346 http://dx.doi.org/10.1186/2047-1440-3-10 |
work_keys_str_mv | AT dahlkeerin systematicreviewofmelanomaincidenceandprognosisinsolidorgantransplantrecipients AT murraychristianalexander systematicreviewofmelanomaincidenceandprognosisinsolidorgantransplantrecipients AT kitchenjessica systematicreviewofmelanomaincidenceandprognosisinsolidorgantransplantrecipients AT chananwen systematicreviewofmelanomaincidenceandprognosisinsolidorgantransplantrecipients |