HIV-Infected Individuals with Low CD4/CD8 Ratio despite Effective Antiretroviral Therapy Exhibit Altered T Cell Subsets, Heightened CD8+ T Cell Activation, and Increased Risk of Non-AIDS Morbidity and Mortality

A low CD4/CD8 ratio in elderly HIV-uninfected adults is associated with increased morbidity and mortality. A subset of HIV-infected adults receiving effective antiretroviral therapy (ART) fails to normalize this ratio, even after they achieve normal CD4+ T cell counts. The immunologic and clinical c...

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Detalles Bibliográficos
Autores principales: Serrano-Villar, Sergio, Sainz, Talia, Lee, Sulggi A., Hunt, Peter W., Sinclair, Elizabeth, Shacklett, Barbara L., Ferre, April L., Hayes, Timothy L., Somsouk, Ma, Hsue, Priscilla Y., Van Natta, Mark L., Meinert, Curtis L., Lederman, Michael M., Hatano, Hiroyu, Jain, Vivek, Huang, Yong, Hecht, Frederick M., Martin, Jeffrey N., McCune, Joseph M., Moreno, Santiago, Deeks, Steven G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022662/
https://www.ncbi.nlm.nih.gov/pubmed/24831517
http://dx.doi.org/10.1371/journal.ppat.1004078

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