T Cell Inactivation by Poxviral B22 Family Proteins Increases Viral Virulence

Infections with monkeypox, cowpox and weaponized variola virus remain a threat to the increasingly unvaccinated human population, but little is known about their mechanisms of virulence and immune evasion. We now demonstrate that B22 proteins, encoded by the largest genes of these viruses, render hu...

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Detalles Bibliográficos
Autores principales: Alzhanova, Dina, Hammarlund, Erika, Reed, Jason, Meermeier, Erin, Rawlings, Stephanie, Ray, Caroline A., Edwards, David M., Bimber, Ben, Legasse, Alfred, Planer, Shannon, Sprague, Jerald, Axthelm, Michael K., Pickup, David J., Lewinsohn, David M., Gold, Marielle C., Wong, Scott W., Sacha, Jonah B., Slifka, Mark K., Früh, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022744/
https://www.ncbi.nlm.nih.gov/pubmed/24832205
http://dx.doi.org/10.1371/journal.ppat.1004123

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