Cargando…

HVEM is a TNF Receptor with Multiple Regulatory Roles in the Mucosal Immune System

The herpes virus entry mediator (HVEM) is a member of the tumor necrosis factor receptor superfamily (TNFRSF), and therefore it is also known as TNFRSF14 or CD270 (1,2). In recent years, we have focused on understanding HVEM function in the mucosa of the intestine, particularly on the role of HVEM i...

Descripción completa

Detalles Bibliográficos
Autores principales: Shui, Jr-Wen, Kronenberg, Mitchell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022780/
https://www.ncbi.nlm.nih.gov/pubmed/24851095
http://dx.doi.org/10.4110/in.2014.14.2.67
_version_ 1782316467263373312
author Shui, Jr-Wen
Kronenberg, Mitchell
author_facet Shui, Jr-Wen
Kronenberg, Mitchell
author_sort Shui, Jr-Wen
collection PubMed
description The herpes virus entry mediator (HVEM) is a member of the tumor necrosis factor receptor superfamily (TNFRSF), and therefore it is also known as TNFRSF14 or CD270 (1,2). In recent years, we have focused on understanding HVEM function in the mucosa of the intestine, particularly on the role of HVEM in colitis pathogenesis, host defense and regulation of the microbiota (2,3,4). HVEM is an unusual TNF receptor because of its high expression levels in the gut epithelium, its capacity to bind ligands that are not members of the TNF super family, including immunoglobulin (Ig) superfamily members BTLA and CD160, and its bi-directional functionality, acting as a signaling receptor or as a ligand for the receptor BTLA. Clinically, Hvem recently was reported as an inflammatory bowel disease (IBD) risk gene as a result of genome wide association studies (5,6). This suggests HVEM could have a regulatory role influencing the regulation of epithelial barrier, host defense and the microbiota. Consistent with this, using mouse models, we have revealed how HVEM is involved in colitis pathogenesis, mucosal host defense and epithelial immunity (3,7). Although further studies are needed, our results provide the fundamental basis for understanding why Hvem is an IBD risk gene, and they confirm that HVEM is a mucosal gatekeeper with multiple regulatory functions in the mucosa.
format Online
Article
Text
id pubmed-4022780
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher The Korean Association of Immunologists
record_format MEDLINE/PubMed
spelling pubmed-40227802014-05-21 HVEM is a TNF Receptor with Multiple Regulatory Roles in the Mucosal Immune System Shui, Jr-Wen Kronenberg, Mitchell Immune Netw Review Article The herpes virus entry mediator (HVEM) is a member of the tumor necrosis factor receptor superfamily (TNFRSF), and therefore it is also known as TNFRSF14 or CD270 (1,2). In recent years, we have focused on understanding HVEM function in the mucosa of the intestine, particularly on the role of HVEM in colitis pathogenesis, host defense and regulation of the microbiota (2,3,4). HVEM is an unusual TNF receptor because of its high expression levels in the gut epithelium, its capacity to bind ligands that are not members of the TNF super family, including immunoglobulin (Ig) superfamily members BTLA and CD160, and its bi-directional functionality, acting as a signaling receptor or as a ligand for the receptor BTLA. Clinically, Hvem recently was reported as an inflammatory bowel disease (IBD) risk gene as a result of genome wide association studies (5,6). This suggests HVEM could have a regulatory role influencing the regulation of epithelial barrier, host defense and the microbiota. Consistent with this, using mouse models, we have revealed how HVEM is involved in colitis pathogenesis, mucosal host defense and epithelial immunity (3,7). Although further studies are needed, our results provide the fundamental basis for understanding why Hvem is an IBD risk gene, and they confirm that HVEM is a mucosal gatekeeper with multiple regulatory functions in the mucosa. The Korean Association of Immunologists 2014-04 2014-04-21 /pmc/articles/PMC4022780/ /pubmed/24851095 http://dx.doi.org/10.4110/in.2014.14.2.67 Text en Copyright © 2014 The Korean Association of Immunologists http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Shui, Jr-Wen
Kronenberg, Mitchell
HVEM is a TNF Receptor with Multiple Regulatory Roles in the Mucosal Immune System
title HVEM is a TNF Receptor with Multiple Regulatory Roles in the Mucosal Immune System
title_full HVEM is a TNF Receptor with Multiple Regulatory Roles in the Mucosal Immune System
title_fullStr HVEM is a TNF Receptor with Multiple Regulatory Roles in the Mucosal Immune System
title_full_unstemmed HVEM is a TNF Receptor with Multiple Regulatory Roles in the Mucosal Immune System
title_short HVEM is a TNF Receptor with Multiple Regulatory Roles in the Mucosal Immune System
title_sort hvem is a tnf receptor with multiple regulatory roles in the mucosal immune system
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022780/
https://www.ncbi.nlm.nih.gov/pubmed/24851095
http://dx.doi.org/10.4110/in.2014.14.2.67
work_keys_str_mv AT shuijrwen hvemisatnfreceptorwithmultipleregulatoryrolesinthemucosalimmunesystem
AT kronenbergmitchell hvemisatnfreceptorwithmultipleregulatoryrolesinthemucosalimmunesystem