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HVEM is a TNF Receptor with Multiple Regulatory Roles in the Mucosal Immune System
The herpes virus entry mediator (HVEM) is a member of the tumor necrosis factor receptor superfamily (TNFRSF), and therefore it is also known as TNFRSF14 or CD270 (1,2). In recent years, we have focused on understanding HVEM function in the mucosa of the intestine, particularly on the role of HVEM i...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Association of Immunologists
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022780/ https://www.ncbi.nlm.nih.gov/pubmed/24851095 http://dx.doi.org/10.4110/in.2014.14.2.67 |
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author | Shui, Jr-Wen Kronenberg, Mitchell |
author_facet | Shui, Jr-Wen Kronenberg, Mitchell |
author_sort | Shui, Jr-Wen |
collection | PubMed |
description | The herpes virus entry mediator (HVEM) is a member of the tumor necrosis factor receptor superfamily (TNFRSF), and therefore it is also known as TNFRSF14 or CD270 (1,2). In recent years, we have focused on understanding HVEM function in the mucosa of the intestine, particularly on the role of HVEM in colitis pathogenesis, host defense and regulation of the microbiota (2,3,4). HVEM is an unusual TNF receptor because of its high expression levels in the gut epithelium, its capacity to bind ligands that are not members of the TNF super family, including immunoglobulin (Ig) superfamily members BTLA and CD160, and its bi-directional functionality, acting as a signaling receptor or as a ligand for the receptor BTLA. Clinically, Hvem recently was reported as an inflammatory bowel disease (IBD) risk gene as a result of genome wide association studies (5,6). This suggests HVEM could have a regulatory role influencing the regulation of epithelial barrier, host defense and the microbiota. Consistent with this, using mouse models, we have revealed how HVEM is involved in colitis pathogenesis, mucosal host defense and epithelial immunity (3,7). Although further studies are needed, our results provide the fundamental basis for understanding why Hvem is an IBD risk gene, and they confirm that HVEM is a mucosal gatekeeper with multiple regulatory functions in the mucosa. |
format | Online Article Text |
id | pubmed-4022780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Korean Association of Immunologists |
record_format | MEDLINE/PubMed |
spelling | pubmed-40227802014-05-21 HVEM is a TNF Receptor with Multiple Regulatory Roles in the Mucosal Immune System Shui, Jr-Wen Kronenberg, Mitchell Immune Netw Review Article The herpes virus entry mediator (HVEM) is a member of the tumor necrosis factor receptor superfamily (TNFRSF), and therefore it is also known as TNFRSF14 or CD270 (1,2). In recent years, we have focused on understanding HVEM function in the mucosa of the intestine, particularly on the role of HVEM in colitis pathogenesis, host defense and regulation of the microbiota (2,3,4). HVEM is an unusual TNF receptor because of its high expression levels in the gut epithelium, its capacity to bind ligands that are not members of the TNF super family, including immunoglobulin (Ig) superfamily members BTLA and CD160, and its bi-directional functionality, acting as a signaling receptor or as a ligand for the receptor BTLA. Clinically, Hvem recently was reported as an inflammatory bowel disease (IBD) risk gene as a result of genome wide association studies (5,6). This suggests HVEM could have a regulatory role influencing the regulation of epithelial barrier, host defense and the microbiota. Consistent with this, using mouse models, we have revealed how HVEM is involved in colitis pathogenesis, mucosal host defense and epithelial immunity (3,7). Although further studies are needed, our results provide the fundamental basis for understanding why Hvem is an IBD risk gene, and they confirm that HVEM is a mucosal gatekeeper with multiple regulatory functions in the mucosa. The Korean Association of Immunologists 2014-04 2014-04-21 /pmc/articles/PMC4022780/ /pubmed/24851095 http://dx.doi.org/10.4110/in.2014.14.2.67 Text en Copyright © 2014 The Korean Association of Immunologists http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Shui, Jr-Wen Kronenberg, Mitchell HVEM is a TNF Receptor with Multiple Regulatory Roles in the Mucosal Immune System |
title | HVEM is a TNF Receptor with Multiple Regulatory Roles in the Mucosal Immune System |
title_full | HVEM is a TNF Receptor with Multiple Regulatory Roles in the Mucosal Immune System |
title_fullStr | HVEM is a TNF Receptor with Multiple Regulatory Roles in the Mucosal Immune System |
title_full_unstemmed | HVEM is a TNF Receptor with Multiple Regulatory Roles in the Mucosal Immune System |
title_short | HVEM is a TNF Receptor with Multiple Regulatory Roles in the Mucosal Immune System |
title_sort | hvem is a tnf receptor with multiple regulatory roles in the mucosal immune system |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022780/ https://www.ncbi.nlm.nih.gov/pubmed/24851095 http://dx.doi.org/10.4110/in.2014.14.2.67 |
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